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Specific interchromosomal contacts in olfactory sensory neurons form a super-enhancer that controls the expression of a single olfactory receptor in each neuron.
Cryo-electron microscopy structures of feline calicivirus and its cellular receptor show that twelve copies of the minor capsid protein VP2 form a portal-like assembly arranged about a pore in the capsid shell.
A three-dimensional photonic topological insulator is presented, made of split-ring resonators with strong magneto-electric coupling, which has an extremely wide topological bandgap, forbidding light propagation.
Cryo-electron microscopy structures of bacterial RNAP–promoter DNA complexes, including structures of partially melted intermediates, suggest a universally conserved common mechanism for promoter DNA opening prior to gene expression.
A second repeating fast radio burst is detected, showing behaviour similar to that of the first, and demonstrating that repeaters are unlikely to be rare.
Wind from the most massive star in the Trapezium cluster in Orion has carved out a large and expanding cavity around the cluster, bounded by a thin, 2,600-solar-mass shell.
The thermal neutron capture cross-section of 88Zr is measured to be 861,000 ± 69,000 barns, the second-largest neutron capture cross-section ever measured.
In physiologically normal epithelia, age-related expansion of clones that carry mutations in NOTCH1 and other driver genes is accelerated by risk factors for developing oesophageal squamous cell carcinoma, such as alcohol consumption or smoking.
Femtosecond time-resolved X-ray diffraction reveals that in the ultrafast demagnitization of ferromagnetic iron, about 80% of the angular momentum lost from the spins is transferred to the lattice on a sub-picosecond timescale.
Isolates of the Vibrio cholerae O1 serotype Ogawa from Yemen are from a single sublineage of the seventh pandemic El Tor (7PET) lineage and are susceptible to several commonly used antibiotics as well as to polymyxins.
Subglacially produced methane of microbial origin is flushed to the ice margin of the Greenland ice sheet by meltwater, contributing to a previously unaccounted for methane flux to the atmosphere.
Cryo-electron microscopy structures are reported in which the full-length human α1β3γ2L GABAA receptor in lipid nanodiscs is bound to the channel-blocker picrotoxin, the competitive antagonist bicuculline, the agonist GABA, and the benzodiazepines alprazolam and diazepam.
A closed-loop implantable bioelectronic device that can modulate peripheral neuronal activity is used to improve bladder function in a rat model of cystitis.
A high-resolution cryo-electron microscopy structure is reported for the full-length human α1β3γ2L GABAA receptor, functionally reconstituted in lipid nanodiscs.
In a mouse model of ischaemic stroke, regulatory T cells infiltrate the injured brain in response to the chemokines CCL1 and CCL20 and suppress excessive astrogliosis via the production of amphiregulin.