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SETD3 methylates mammalian actin at His73, and SETD3 deficiency impairs stimulus-induced contraction in primary human uterine smooth muscle cells and leads to maternal dystocia in mice.
Satellite observations reveal over 200 ammonia hotspots associated with agricultural and industrial point sources, which emit much larger quantities of ammonia to the atmosphere than previously thought.
The presence of blubber and distribution of melanophores in a countershading pattern in an Early Jurassic ichthyosaur demonstrate that the evolutionary convergence of these reptiles with extant marine amniotes extends to the cellular and molecular levels.
The differentiation of the inner ear in the lamprey Lethenteron camtschaticum and hagfish Eptatretus burgeri sheds light on the evolution of the semicircular canals of jawed vertebrates.
A magnetically induced two-dimensional square lattice of merons and antimerons is observed in real space, along with its transformation into a hexagonal lattice of skyrmions at room temperature.
Orthogonal ribosomes are engineered in which the two subunits are stapled together in a way that limits association with endogenous subunits in cells, enabling the evolution of new functionality in the orthogonal ribosome.
Ice-core-derived melt records reveal that atmospheric warming has recently intensified Greenland ice-sheet surface melt and runoff to levels that are exceptional over at least the last 350 years.
The distinctive 20Ne/22Ne ratio in material thought to come from deep mantle plumes provides evidence for nebular gas as a source of volatiles in Earth’s interior.
Early results from the COSINE-100 experiment—designed to test a much-debated claim of the detection of a dark-matter signal—show no indications of dark matter, providing evidence against the previous claim.
Pyramidal neurons in the hippocampal CA2 region in mice promote social aggression via a disinhibitory circuit involving the lateral septum and ventromedial hypothalamus.
α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and human thrombomodulin require non-ischaemic preservation with continuous perfusion and post-transplantation growth control to ensure long-term orthotopic function of the xenograft in baboons.
Combinatorial tagging of single cells using expressed DNA barcodes, delivered by a lentiviral vector, is used to track individual cells and reconstruct their lineages and trajectories during cell fate reprogramming.
A scalable spintronic device operating via spin–orbit transduction and magnetoelectric switching and using advanced quantum materials shows non-volatility and improved performance and energy efficiency compared with CMOS devices.
Magma storage and differentiation in the Earth’s crust mainly occurs by reactive melt flow in long-lived mush reservoirs, rather than by fractional crystallization in magma chambers, as previously thought.
A modelling framework is presented to determine the optimal layout and physical properties of networks in which the nodes and links have physical sizes and intersections between components is prohibited.