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This paper, one of two published that show Sld2 and Sld3 constitute the minimal group of cyclin-dependent kinase (CDK) targets necessary to promote replication, also finds that the function of G1 CDKs in replication is not just to activate the S-phase CDKs, but also to regulate the Cdc7 kinase regulatory subunit, Dbf4.
This paper, one of two published that show Sld2 and Sld3 constitute the minimal group of cyclin-dependent kinase (CDK) targets necessary to promote replication, also finds that the function of G1 CDKs in replication is not just to activate the S-phase CDKs, but also to regulate the Cdc7 kinase regulatory subunit, Dbf4.
One of two papers that describe how botulinum toxins produced by Clostridium botulinum are potent inhibitors of neurotransmitter release by elucidating the crystal structure of botulinum toxin B bound to its receptor.
One of two papers that describe how botulinum toxins produced by Clostridium botulinum are potent inhibitors of neurotransmitter release by elucidating the crystal structure of botulinum toxin B bound to its receptor.
Identification of two CO2 receptors in Drosophila antennae, Gr21a and Gr63a, determines that their co-expression is necessary and sufficient for CO2 sensing. Flies lacking one of the two are insensitive to CO2, and confer CO2 responsivity when both receptors are expressed in heterologous neurons.
The heat-shock protein Hsp70 can regulate the development of red blood cells, or erythropoiesis. Hsp70 interacts with GATA-1 and protects it from cleavage, thus controlling the differentiation of erythrocytes by its presence in the nucleus.
Active galactic nuclei vary in a manner similar to Galactic black hole systems when appropriately scaled up by mass, meaning it is possible to determine how active galactic nuclei should behave on cosmological timescales by studying the brighter and much faster varying Galactic systems.
In laser-plasma based particle accelerators, a second laser pulse colliding with the first is used to obtain better control over the injection and subsequent acceleration of electrons. In this scheme, the electron beams are highly collimated, monoenergetic (with energy spread < 10%), tuneable (between 15 and 250 MeV) and most importantly, stable.