Latest Research

  • Letter |

    Geophysical and geological data reveal increased ice-sheet variability and surface meltwater—possibly analogous to future conditions—offshore of the Aurora subglacial basin of East Antarctica during warm climate intervals of the past 50 million years.

    • Sean P. S. Gulick
    • , Amelia E. Shevenell
    • , Aleksandr Montelli
    • , Rodrigo Fernandez
    • , Catherine Smith
    • , Sophie Warny
    • , Steven M. Bohaty
    • , Charlotte Sjunneskog
    • , Amy Leventer
    • , Bruce Frederick
    •  & Donald D. Blankenship
  • Article |

    In vivo deuterium labelling reveals a quiescent population of long-lived human virus-specific memory CD8 T cells that maintain the epigenetic landscape of effector cells, which facilitates rapid responses to pathogen re-exposure.

    • Rama S. Akondy
    • , Mark Fitch
    • , Srilatha Edupuganti
    • , Shu Yang
    • , Haydn T. Kissick
    • , Kelvin W. Li
    • , Ben A. Youngblood
    • , Hossam A. Abdelsamed
    • , Donald J. McGuire
    • , Kristen W. Cohen
    • , Gabriela Alexe
    • , Shashi Nagar
    • , Megan M. McCausland
    • , Satish Gupta
    • , Pramila Tata
    • , W. Nicholas Haining
    • , M. Juliana McElrath
    • , David Zhang
    • , Bin Hu
    • , William J. Greenleaf
    • , Jorg J. Goronzy
    • , Mark J. Mulligan
    • , Marc Hellerstein
    •  & Rafi Ahmed
  • Letter |

    Computationally designed icosahedral protein-based assemblies can protect their genetic material and evolve in biochemical environments, suggesting a route to the custom design of synthetic nanomaterials for non-viral drug delivery.

    • Gabriel L. Butterfield
    • , Marc J. Lajoie
    • , Heather H. Gustafson
    • , Drew L. Sellers
    • , Una Nattermann
    • , Daniel Ellis
    • , Jacob B. Bale
    • , Sharon Ke
    • , Garreck H. Lenz
    • , Angelica Yehdego
    • , Rashmi Ravichandran
    • , Suzie H. Pun
    • , Neil P. King
    •  & David Baker
  • Letter |

    Electron cryo-microscopy density maps of mouse TMEM16A reconstituted in nanodiscs or solubilized in detergent reveal two functional states of calcium-activated chloride channels.

    • Shangyu Dang
    • , Shengjie Feng
    • , Jason Tien
    • , Christian J. Peters
    • , David Bulkley
    • , Marco Lolicato
    • , Jianhua Zhao
    • , Kathrin Zuberbühler
    • , Wenlei Ye
    • , Lijun Qi
    • , Tingxu Chen
    • , Charles S. Craik
    • , Yuh Nung Jan
    • , Daniel L. Minor Jr
    • , Yifan Cheng
    •  & Lily Yeh Jan
  • Article |

    In bilaterian animals, the final configurations of central nervous systems seem unrelated to neuroectodermal patterning systems, so it is likely that the various architectures of the ventral nerve cords evolved convergently, many times.

    • José M. Martín-Durán
    • , Kevin Pang
    • , Aina Børve
    • , Henrike Semmler Lê
    • , Anlaug Furu
    • , Johanna Taylor Cannon
    • , Ulf Jondelius
    •  & Andreas Hejnol
  • Letter |

    DNA methylation profiling of virus-specific T cells during acute viral infection in mice provides evidence that a fate-permissive subset of effector CD8 T cells dedifferentiates into long-lived memory T cells.

    • Ben Youngblood
    • , J. Scott Hale
    • , Haydn T. Kissick
    • , Eunseon Ahn
    • , Xiaojin Xu
    • , Andreas Wieland
    • , Koichi Araki
    • , Erin E. West
    • , Hazem E. Ghoneim
    • , Yiping Fan
    • , Pranay Dogra
    • , Carl W. Davis
    • , Bogumila T. Konieczny
    • , Rustom Antia
    • , Xiaodong Cheng
    •  & Rafi Ahmed
  • Letter |

    ‘Coincidence-detecting’ phosphoinositide sensors are used to study changes in the phosphoinositide lipid species found in membranes during the development and maturation of endocytic clathrin-coated vesicles.

    • Kangmin He
    • , Robert Marsland III
    • , Srigokul Upadhyayula
    • , Eli Song
    • , Song Dang
    • , Benjamin R. Capraro
    • , Weiming Wang
    • , Wesley Skillern
    • , Raphael Gaudin
    • , Minghe Ma
    •  & Tom Kirchhausen
  • Erratum |

    • Sunitha R. Pangala
    • , Alex Enrich-Prast
    • , Luana S. Basso
    • , Roberta Bittencourt Peixoto
    • , David Bastviken
    • , Edward R. C. Hornibrook
    • , Luciana V. Gatti
    • , Humberto Marotta
    • , Luana Silva Braucks Calazans
    • , Cassia Mônica Sakuragui
    • , Wanderley Rodrigues Bastos
    • , Olaf Malm
    • , Emanuel Gloor
    • , John Bharat Miller
    •  & Vincent Gauci
  • Letter |

    Miniature hydrogel compartments in scalable stacked and folded geometries were used to prepare a contact-activated artificial electric organ.

    • Thomas B. H. Schroeder
    • , Anirvan Guha
    • , Aaron Lamoureux
    • , Gloria VanRenterghem
    • , David Sept
    • , Max Shtein
    • , Jerry Yang
    •  & Michael Mayer
  • Article |

    The cryo-electron microscopy and crystal structures of several mTORC1 complexes, and accompanying biochemical analyses, shed light on how mTORC1 is regulated and how cancer mutations lead to its hyperactivation.

    • Haijuan Yang
    • , Xiaolu Jiang
    • , Buren Li
    • , Hyo J. Yang
    • , Meredith Miller
    • , Angela Yang
    • , Ankita Dhar
    •  & Nikola P. Pavletich
  • Letter |

    A meta-analysis and field data show that frequent fires in savannas and broadleaf forests decrease soil carbon and nitrogen over many decades; modelling shows that nitrogen loss drives carbon loss by reducing net primary productivity.

    • Adam F. A. Pellegrini
    • , Anders Ahlström
    • , Sarah E. Hobbie
    • , Peter B. Reich
    • , Lars P. Nieradzik
    • , A. Carla Staver
    • , Bryant C. Scharenbroch
    • , Ari Jumpponen
    • , William R. L. Anderegg
    • , James T. Randerson
    •  & Robert B. Jackson
  • Letter |

    All necessary strands for DNA origami can be created in a single scalable process by using bacteriophages to generate single-stranded precursor DNA containing the target sequences interleaved with self-excising DNA enzymes.

    • Florian Praetorius
    • , Benjamin Kick
    • , Karl L. Behler
    • , Maximilian N. Honemann
    • , Dirk Weuster-Botz
    •  & Hendrik Dietz
  • Letter |

    DNA bricks with binding domains of 13 nucleotides instead of the typical 8 make it possible to self-assemble gigadalton-scale, three-dimensional nanostructures consisting of tens of thousands of unique components.

    • Luvena L. Ong
    • , Nikita Hanikel
    • , Omar K. Yaghi
    • , Casey Grun
    • , Maximilian T. Strauss
    • , Patrick Bron
    • , Josephine Lai-Kee-Him
    • , Florian Schueder
    • , Bei Wang
    • , Pengfei Wang
    • , Jocelyn Y. Kishi
    • , Cameron Myhrvold
    • , Allen Zhu
    • , Ralf Jungmann
    • , Gaetan Bellot
    • , Yonggang Ke
    •  & Peng Yin
  • Article |

    Disulfiram is metabolized into copper–diethyldithiocarbamate, which binds to NPL4 and induces its aggregation in cells, leading to blockade of the p97–NPL4–UFD1 pathway and induction of a complex cellular phenotype that results in cell death.

    • Zdenek Skrott
    • , Martin Mistrik
    • , Klaus Kaae Andersen
    • , Søren Friis
    • , Dusana Majera
    • , Jan Gursky
    • , Tomas Ozdian
    • , Jirina Bartkova
    • , Zsofia Turi
    • , Pavel Moudry
    • , Marianne Kraus
    • , Martina Michalova
    • , Jana Vaclavkova
    • , Petr Dzubak
    • , Ivo Vrobel
    • , Pavla Pouckova
    • , Jindrich Sedlacek
    • , Andrea Miklovicova
    • , Anne Kutt
    • , Jing Li
    • , Jana Mattova
    • , Christoph Driessen
    • , Q. Ping Dou
    • , Jørgen Olsen
    • , Marian Hajduch
    • , Boris Cvek
    • , Raymond J. Deshaies
    •  & Jiri Bartek
  • Letter |

    Two extremely massive galaxies are seen 800 million years after the Big Bang, showing the rapid growth of early structure and marking the most massive halo known in that era.

    • D. P. Marrone
    • , J. S. Spilker
    • , C. C. Hayward
    • , J. D. Vieira
    • , M. Aravena
    • , M. L. N. Ashby
    • , M. B. Bayliss
    • , M. Béthermin
    • , M. Brodwin
    • , M. S. Bothwell
    • , J. E. Carlstrom
    • , S. C. Chapman
    • , Chian-Chou Chen
    • , T. M. Crawford
    • , D. J. M. Cunningham
    • , C. De Breuck
    • , C. D. Fassnacht
    • , A. H. Gonzalez
    • , T. R. Greve
    • , Y. D. Hezaveh
    • , K. Lacaille
    • , K. C. Litke
    • , S. Lower
    • , J. Ma
    • , M. Malkan
    • , T. B. Miller
    • , W. R. Morningstar
    • , E. J. Murphy
    • , D. Narayanan
    • , K. A. Phadke
    • , K. M. Rotermund
    • , J. Sreevani
    • , B. Stalder
    • , A. A. Stark
    • , M. L. Strandet
    • , M. Tang
    •  & A. Weiß