Volume 556 Issue 7702, 26 April 2018

As officials meet in Bonn to swap stories on progress towards the Paris goals, only emissions cuts will guarantee a happy ending.

Results from a Nature photo competition show the power of images.

Linking a lab with others fosters crucial camaraderie, collaboration and productivity, writes Rebecca Heald.

Resplendent reptile and two similar species have been discovered in the remote forests of Madagascar.

Microbes pump out acid until they burst.

Compound prevents deterioration of an inexpensive component.

Species comparison confirms downsides of asexual reproduction.

Children use adult-like tactics to tackle ‘tragedy of the commons’ puzzle.

Machine made from off-the-shelf components constructs chair from a kit in less than 25 minutes.

Miniature capsules deliver enzymes that quickly cut blood-alcohol levels.

Minerals in miniature gems point to origins in the early Solar System.

A rise in body temperature directly affects brain cells that regulate eating.

The week in science: 20–26 April 2018.

New climate-inequality tool quantifies how quickly the weather will veer beyond normal in different regions.

Young researchers who narrowly miss out on postdoctoral grant struggle to compete with those who just qualify.

Images from Landsat satellites and agricultural-survey programme are freely available to scientists — but for how long?

With relocation from London to Amsterdam less than a year away, the European Medicines Agency is facing uncertainty.

Researchers hope European–Russian Trace Gas Orbiter will end a long-running debate over source of the gas on Mars.

Direct sequencing of RNA molecules such as virus genomes could help to unpick role of mysterious chemical modifications in genetic material.

Clean energy is growing quickly. But time is running out to rein in carbon emissions.

Scientists want to combat dementia and neurodegeneration by keeping the brain’s immune system from going rogue.

Difficult questions will be raised as models of the human brain get closer to replicating its functions, explain Nita A. Farahany, Henry T. Greely and 15 colleagues.

S. F. Said explores a study on children’s books as preparation for planetary crises.

Barbara Kiser reviews five of the week’s best science picks.

In this year’s contest, Nature follows scientists from starry Antarctic fields to African volcanic plains.

A catalyst has been developed that recognizes the topology of just one face of a planar reaction intermediate. Remarkably, this enables one mirror-image isomer of the reaction product to be made selectively.

An epidemiological study of adolescents who had acquired HIV around the time of birth highlights how high-income countries benefit from the ability to begin treating all infected children in the first years of life.

Migration of brine shrimp causes substantial mixing of the water column.

Single-cell analyses in cancer are limited by the small biomass of individual cells. In vitro production of 3D organoid structures from single tumour-derived cells generates sufficient biomass for in-depth analyses.

Cancers of epithelial-cell origin often contain some tumour cells that have acquired traits of mesenchymal cells. How this leads to cancer spread has now been illuminated in mouse models.

Two experiments have demonstrated entanglement — non-classical correlations — between remote mechanical systems comprising billions of atoms. The results could advance our understanding of quantum physics.

A neuronal population has now been found that regulates two competing needs — hunger and pain. Urgent pain overrides hunger, but appetite-inducing neuronal activity dampens long-term pain responses to enable feeding.

Cooperation between a chiral hydrogen-bond-donor catalyst and a strong Lewis-acid promoter in an S_N1-type reaction mediates the formation of tertiary carbocations and enables control over enantioselectivity and product distribution.

A new version of the phylogenetic bootstrap method enables assessment of the robustness of phylogenies that are based on large datasets of hundreds or thousands of taxa.

Organoids derived from individual cells from colorectal cancers and adjacent normal tissue are used to investigate intra-tumour diversification at the genomic, epigenetic and functional levels.

Epithelial-to-mesenchymal transition in tumour cells occurs through distinct intermediate states, associated with different metastatic potential, cellular properties, gene expression, and chromatin landscape

Observations of carbon monoxide and ionized carbon lines from the source SPT2349-56 show it to contain a cluster of at least fourteen gas-rich galaxies with redshifts of 4.31, in a highly dense core region.

Remote quantum entanglement is demonstrated in a micromachined solid-state system comprising two optomechanical oscillators across two chips physically separated by 20 cm and with an optical separation of around 70 m.

Quantum entanglement is demonstrated in a system of massive micromechanical oscillators coupled to a microwave-frequency electromagnetic cavity by driving the devices into a steady state that is entangled.

Ohmic losses in plasmonic devices can be reduced by exploiting ‘resonant switching’, in which light couples to surface plasmon polaritons only when in resonance and bypasses them otherwise.

During continent collision and associated mountain building, a surprisingly large volume of the lower crust is shown to be affected by earthquake aftershocks, producing a top-down effect on crustal geodynamics.

Acute heat stress from the extended marine heatwave of 2016 is a potent driver of the transformation of coral assemblages, which affects even the most remote and well-protected reefs of the Great Barrier Reef.

Laboratory experiments with the brine shrimp Artemia salina illustrate the potential for turbulence generated by the diurnal vertical migrations of aggregations of centimetre-scale zooplankton to affect the physical and biogeochemical structure of oceanic water columns.

The immunoregulatory metabolite itaconate and its dimethyl derivative induce electrophilic stress and react with glutathione to induce both Nrf2-dependent and Nrf2-independent responses, resulting in AF3-mediated inhibition of the inflammation-related protein IκBζ.

A subset of neurons in the hypothalamus is identified as the primary site of action for regulating energy balance and glucose homeostasis by leptin.

Binding of an embryonic stem in two cases cell-specific transcription factor pre-marks cell-type-restricted enhancers in embryonic stem in two cases cells, and this premarking is required for the robustness of enhancer activation in differentiated cells.

A high-resolution X-ray structure and molecular dynamics simulations of the N-methyl-d-aspartate receptor in complexes with channel-blocking ligands reveals the molecular basis of the ligand binding and channel block.

Crystal structures of the neuropeptide Y₁ receptor in complex with two distinct antagonists combined with NMR, molecular docking and mutagenesis studies inform a proposed model for receptor–agonist binding.