Table of Contents

Volume 550 Number 7676 pp301-424

19 October 2017

About the cover

The workplace is changing. Dramatic shifts in labour are reshaping society, the environment and the political landscape. Around the globe, computers and robots are poised to replace people in a wide variety of jobs. In this issue, Nature asks: what light is research shedding on the future of work and how will these changes affect scientists' working world? A News Feature explores three of the most studied questions about the future of work: what jobs are most at risk of automation? Do shifts to a decentralized 'gig economy' make good on their promise to democratize work around the world? And what kinds of programmes are best preparing workers for the coming changes? A Careers Feature examines the gig economy in more detail, revealing how freelance opportunities are remodelling what it means to be a researcher. And in three Comment pieces, Robert Allen provides a historical perspective on the relationship between wages and productivity; Yuval Noah Harari seeks new socio-economic models and a revolution in education; and Ian Goldin suggests that our era has more parallels with the Renaissance than the Industrial Revolution. Cover image: Chris Malbon

This Week



World View


Research Highlights


Seven Days


News in Focus


  • The future of work

    No Alt text available for this image

    Digital technologies are upending the workforce. The right research can tell us how.


  • Reboot for the AI revolution

    As artificial intelligence puts many out of work, we must forge new economic, social and educational systems, argues Yuval Noah Harari.

  • The second Renaissance

    Ian Goldin calls on scientists to help society to weather the disruptive transformations afoot.

Books and Arts








  • Trade talk: Habitat helper

    Canadian researcher helps to support wildlife by encouraging the government to incorporate science into policy.

    • Sarah Boon

naturejobs job listings and advertising features




  • DNA sequencing at 40: past, present and future

    • Jay Shendure
    • Shankar Balasubramanian
    • George M. Church
    • Walter Gilbert
    • Jane Rogers
    • Jeffery A. Schloss
    • Robert H. Waterston

    The history and future potential of DNA sequencing, including the development of the underlying technologies and the expansion of its areas of application, are reviewed.


  • Mastering the game of Go without human knowledge

    • David Silver
    • Julian Schrittwieser
    • Karen Simonyan
    • Ioannis Antonoglou
    • Aja Huang
    • Arthur Guez
    • Thomas Hubert
    • Lucas Baker
    • Matthew Lai
    • Adrian Bolton
    • Yutian Chen
    • Timothy Lillicrap
    • Fan Hui
    • Laurent Sifre
    • George van den Driessche
    • Thore Graepel
    • Demis Hassabis

    Starting from zero knowledge and without human data, AlphaGo Zero was able to teach itself to play Go and to develop novel strategies that provide new insights into the oldest of games.

    See also
  • BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

    • Weixing Zhao
    • Justin B. Steinfeld
    • Fengshan Liang
    • Xiaoyong Chen
    • David G. Maranon
    • Chu Jian Ma
    • Youngho Kwon
    • Timsi Rao
    • Weibin Wang
    • Chen Sheng
    • Xuemei Song
    • Yanhong Deng
    • Judit Jimenez-Sainz
    • Lucy Lu
    • Ryan B. Jensen
    • Yong Xiong
    • Gary M. Kupfer
    • Claudia Wiese
    • Eric C. Greene
    • Patrick Sung

    The tumour suppressor complex BRCA1–BARD1, which facilitates the generation of a single-stranded DNA template during homologous recombination, also binds to the recombinase RAD51 and enhances its function.

    See also


  • A parts-per-billion measurement of the antiproton magnetic momentOpen

    • C. Smorra
    • S. Sellner
    • M. J. Borchert
    • J. A. Harrington
    • T. Higuchi
    • H. Nagahama
    • T. Tanaka
    • A. Mooser
    • G. Schneider
    • M. Bohman
    • K. Blaum
    • Y. Matsuda
    • C. Ospelkaus
    • W. Quint
    • J. Walz
    • Y. Yamazaki
    • S. Ulmer

    The magnetic moment of the antiproton is measured at the parts-per-billion level, improving on previous measurements by a factor of about 350.

  • Ion sieving in graphene oxide membranes via cationic control of interlayer spacing

    • Liang Chen
    • Guosheng Shi
    • Jie Shen
    • Bingquan Peng
    • Bowu Zhang
    • Yuzhu Wang
    • Fenggang Bian
    • Jiajun Wang
    • Deyuan Li
    • Zhe Qian
    • Gang Xu
    • Gongping Liu
    • Jianrong Zeng
    • Lijuan Zhang
    • Yizhou Yang
    • Guoquan Zhou
    • Minghong Wu
    • Wanqin Jin
    • Jingye Li
    • Haiping Fang

    Cations are used to control the interlayer spacing of graphene oxide membranes, enabling efficient and selective sieving of hydrated cations.

  • Organic long persistent luminescence

    • Ryota Kabe
    • Chihaya Adachi

    A blend of two organic molecules excited by a simple LED light source can release the stored excitation energy slowly as ‘long persistent luminescence’ over periods of up to an hour.

  • Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex

    • Ryan Remedios
    • Ann Kennedy
    • Moriel Zelikowsky
    • Benjamin F. Grewe
    • Mark J. Schnitzer
    • David J. Anderson

    Interactions with male and female intruders activated overlapping neuronal populations in the ventromedial hypothalamus of inexperienced adult male mice, and these ensembles gradually separated as the mice acquired social and sexual experience with conspecifics.

  • Establishment of mouse expanded potential stem cells

    • Jian Yang
    • David J. Ryan
    • Wei Wang
    • Jason Cheuk-Ho Tsang
    • Guocheng Lan
    • Hideki Masaki
    • Xuefei Gao
    • Liliana Antunes
    • Yong Yu
    • Zhexin Zhu
    • Juexuan Wang
    • Aleksandra A. Kolodziejczyk
    • Lia S. Campos
    • Cui Wang
    • Fengtang Yang
    • Zhen Zhong
    • Beiyuan Fu
    • Melanie A. Eckersley-Maslin
    • Michael Woods
    • Yosuke Tanaka
    • Xi Chen
    • Adam C. Wilkinson
    • James Bussell
    • Jacqui White
    • Ramiro Ramirez-Solis
    • Wolf Reik
    • Berthold Göttgens
    • Sarah A. Teichmann
    • Patrick P. L. Tam
    • Hiromitsu Nakauchi
    • Xiangang Zou
    • Liming Lu
    • Pentao Liu

    Cultures of expanded potential stem cells can be established from individual eight-cell blastomeres, and by direct conversion of mouse embryonic stem cells and induced pluripotent stem cells, highlighting the feasibility of establishing expanded potential stem cells for other mammalian species.

  • Radically truncated MeCP2 rescues Rett syndrome-like neurological defects

    • Rebekah Tillotson
    • Jim Selfridge
    • Martha V. Koerner
    • Kamal K. E. Gadalla
    • Jacky Guy
    • Dina De Sousa
    • Ralph D. Hector
    • Stuart R. Cobb
    • Adrian Bird

    Analysis of the minimal functional unit for MeCP2 protein shows that its function is to recruit the NCoR/SMRT co-repressor complex to methylated sites on chromatin, which may have use in designing strategies for gene therapy of Rett syndrome.

    See also
  • Cytoplasmic chromatin triggers inflammation in senescence and cancer

    • Zhixun Dou
    • Kanad Ghosh
    • Maria Grazia Vizioli
    • Jiajun Zhu
    • Payel Sen
    • Kirk J. Wangensteen
    • Johayra Simithy
    • Yemin Lan
    • Yanping Lin
    • Zhuo Zhou
    • Brian C. Capell
    • Caiyue Xu
    • Mingang Xu
    • Julia E. Kieckhaefer
    • Tianying Jiang
    • Michal Shoshkes-Carmel
    • K. M. Ahasan Al Tanim
    • Glen N. Barber
    • John T. Seykora
    • Sarah E. Millar
    • Klaus H. Kaestner
    • Benjamin A. Garcia
    • Peter D. Adams
    • Shelley L. Berger

    Cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer.

    See also
  • Enhanced proofreading governs CRISPR–Cas9 targeting accuracy

    • Janice S. Chen
    • Yavuz S. Dagdas
    • Benjamin P. Kleinstiver
    • Moira M. Welch
    • Alexander A. Sousa
    • Lucas B. Harrington
    • Samuel H. Sternberg
    • J. Keith Joung
    • Ahmet Yildiz
    • Jennifer A. Doudna

    A new engineered version of SpCas9, called HypaCas9, displays enhanced accuracy of editing without significant loss of efficiency at the desired target.