Details of the activity of promising anticancer drugs known as BET inhibitors remain elusive. An approach called click chemistry enables in-depth analysis of how these drugs modulate the function of a crucial target protein, BRD4.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
References
Waring, M. J. et al. Nature Rev. Drug Discov. 14, 475–486 (2015).
Tyler, D. S. et al. Science 356, 1397–1401 (2017).
Blackman, M. L., Royzen, M. & Fox, J. M. J. Am. Chem. Soc. 130, 13518–13519 (2008).
Kolb, H. C., Finn, M. G. & Sharpless, K. B. Angew. Chem. Int. Edn 40, 2004–2021 (2001).
Speers, A. E., Adam, G. C. & Cravatt, B. F. J. Am. Chem. Soc. 125, 4686–4687 (2003).
Fong, C. Y. et al. Nature 525, 538–542 (2015).
Dawson, M. A. et al. Nature 478, 529–533 (2011).
Ong, S.-E. et al. Proc. Natl Acad. Sci. USA 106, 4617–4622 (2009).
Rodriguez, R. & Miller, K. M. Nature Rev. Genet. 15, 783–796 (2014).
Rodriguez, R. et al. Nature Chem. Biol. 8, 301–310 (2012).
Author information
Authors and Affiliations
Corresponding authors
Related links
Rights and permissions
About this article
Cite this article
Vassiliou, G., Balasubramanian, S. Click and discover. Nature 548, 162–164 (2017). https://doi.org/10.1038/548162a
Published:
Issue Date:
DOI: https://doi.org/10.1038/548162a