Table of Contents

Volume 546 Number 7658 pp327-446

15 June 2017

About the cover

Three papers in this issue provide a plethora of new genome sequences for the Zika virus and offer insights into its genetic epidemiology. On page 401, Kristian Andersen and his colleagues reveal 39 new genome sequences obtained from infected patients and Aedes aegypti mosquitoes. Using phylogenetic analysis they conclude that the virus has been introduced to Florida on multiple separate occasions and that most of these events were linked to travel from the Caribbean. Their work also suggests that Zika transmission chains in Florida are unlikely to persist, indicating that future outbreaks would depend on transmission dynamics in the Americas. On page 406, Nuno Faria and his colleagues provide 54 new virus genomes, mostly from northeast Brazil, several sequenced in real time using portable DNA sequencers and a mobile genomics laboratory. Using these and other available sequences they trace the spatial origins and spread of the virus in Brazil and the Americas, revealing that northeast Brazil played a crucial role in establishing the epidemic and the spread of the virus on the continent. And on page 411, Bronwyn MacInnis and her colleagues analyse 110 Zika virus genomes derived from clinical and mosquito samples from ten countries and territories. Their work affirms the rapid expansion of the epidemic within Brazil and multiple introductions to other geographical regions. They also describe the ongoing evolution of the virus and look at how the accumulation of mutations might affect the future performance of diagnostic tests. Cover image: Jasiek Krzysztofiak/Nature

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    Genome sequencing of Zika virus samples from infected patients and Aedes aegypti mosquitoes in Florida shows that the virus was probably introduced into the United States on multiple occasions, and that the Caribbean is the most likely source.

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  • Establishment and cryptic transmission of Zika virus in Brazil and the Americas

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