Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Neuroscience

Dopamine ramps up

We thought we had figured out dopamine, a neuromodulator involved in everything from learning to addiction. But the finding that dopamine levels ramp up as rats navigate to a reward may overthrow current theories. See Letter p.575

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Rewards and the brain.

References

  1. Howe, M. W., Tierney, P. L., Sandberg, S. G., Phillips, P. E. M. & Graybiel, A. M. Nature 500, 575–579 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Sutton, R. S. & Barto, A. G. Reinforcement Learning: An Introduction (MIT Press, 1998).

    MATH  Google Scholar 

  3. Montague, P. R., Dayan, P. & Sejnowski, T. J. J. Neurosci. 16, 1936–1947 (1996).

    Article  CAS  Google Scholar 

  4. Niv, Y. & Schoenbaum, G. Trends Cogn. Sci. 12, 265–272 (2008).

    Article  Google Scholar 

  5. Tobler, P. N., Fiorillo, C. D. & Schultz, W. Science 307, 1642–1645 (2005).

    Article  ADS  CAS  Google Scholar 

  6. Tobler, P. N., Dickinson, A. & Schultz, W. J. Neurosci. 23, 10402–10410 (2003).

    Article  CAS  Google Scholar 

  7. Morris, G., Nevet, A., Arkadir, D., Vaadia, E. & Bergman, H. Nature Neurosci. 9, 1057–1063 (2006).

    Article  CAS  Google Scholar 

  8. Reynolds, J. N. J., Hyland, B. I. & Wickens, J. R. Nature 413, 67–70 (2001).

    Article  ADS  CAS  Google Scholar 

  9. Niv, Y., Daw, N. D., Joel, D. & Dayan, P. Psychopharmacology 191, 507–520 (2007).

    Article  CAS  Google Scholar 

  10. Wanat, M. J., Kuhnen, C. M. & Phillips, P. E. M. J. Neurosci. 30, 12020–12027 (2010).

    Article  CAS  Google Scholar 

  11. Montague, P. R. et al. J. Neurosci. 24, 1754–1759 (2004).

    Article  CAS  Google Scholar 

  12. van der Meer, M. A. A. & Redish, A. D. J. Neurosci. 31, 2843–2854 (2011).

    Article  CAS  Google Scholar 

  13. van der Meer, M. A. A., Johnson, A., Schmitzer-Torbert, N. C. & Redish, A. D. Neuron 67, 25–32 (2010).

    Article  CAS  Google Scholar 

  14. Threlfell, S. et al. Neuron 75, 58–64 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yael Niv.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Niv, Y. Dopamine ramps up. Nature 500, 533–535 (2013). https://doi.org/10.1038/500533a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/500533a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing