Volume 482 Issue 7386, 23 February 2012

Although more debate is needed, the benefits of publishing sensitive data outweigh the risks that have so far been made public.

This year marks the centenary of the birth of Alan Turing. He deserves your attention.

Dishonesty, however tempting, is the wrong way to tackle climate sceptics.

Alan Turing is famous for many reasons. Andrew Hodges delves into why Turing's achievements took so long to be recognized.

The week in science: Animals saved from chemical safety tests; fund launched to clean up methane and black-carbon emissions; and excitement over nanopore DNA sequencing.

Controversial virus studies should be published and oversight of such work strengthened, conference concludes.

Door-to-door recruitment abandoned for US project.

Bioethicists are forced to consider their purpose as leading practitioner joins controversial stem-cell company.

An analysis by Nature reveals who holds the most grants from the US National Institutes of Health.

Fermilab icon plundered amid tight budgets and shifting scientific aims.

Fruits hoarded by ancient ground squirrels give new life to prehistoric plants.

Henry Markram wants €1 billion to model the entire human brain. Sceptics don't think he should get it.

Alan Turing's bridging of logic and machines laid the foundation for digital computers, says George Dyson.

Turing machines and cells have much in common, argues Sydney Brenner.

To celebrate the centenary of the year of Alan Turing's birth, four scientists and entrepreneurs assess the divide between neuroscience and computing.

We are only beginning to see the impact of Turing's influential work on morphogenesis, says John Reinitz.

The natural world's interconnectivity should inspire better models of the Universe, says Barry Cooper.

Giovanni Frazzetto explores how theatre exerts its psychological effects on the emotions.

Just over 30 years after HIV/AIDS was first recognized, three accounts of its ravages intrigue Robin Weiss.

Peter Diamandis is the founder of the non-profit X Prize Foundation, which aims to kick-start research and development to solve humanity's biggest challenges. On the publication this week of his book Abundance, co-authored with journalist Steven Kotler, he explains how technological and social progress will enable us to provide enough food, water and energy for all.

Cells package proteins into vesicles for secretion to the extracellular milieu. A study has now identified an enzyme that modifies the packaging machinery to encapsulate unusually large proteins, such as collagen. See Article p.495

Early data from the Planck space satellite provide information about dust in distant galaxies, as well as in the Milky Way, and on the properties of gas in some of the largest clusters of galaxies in the Universe.

A combination of two light-induced reactions has been used to attach peptides to a polymeric gel, and then to detach them from it. This feat opens up opportunities for studying the effects of signalling molecules on cell behaviour in vitro.

Quantum computing is plagued by noise and small errors. An approach based on topological techniques reduces the sensitivity to errors and boosts the prospects for building practical quantum computers. See Article p.489

Muscarinic acetylcholine receptors mediate many physiological responses of the nervous system. Structures of two of these receptors yield insight into how they bind drugs and their mechanism of action. See Letters p.547 & 552

A genetic study of brain cancers in mice and humans reveals distinct mutations in primary tumours and their metastases, suggesting that the two disease 'compartments' may require different treatments.

Melting glaciers contribute to sea-level rise, but measuring their mass loss over time is difficult. An analysis of satellite data on Earth's changing gravity field does just that, and delivers some unexpected results.

Scientific reproducibility now very often depends on the computational method being available to duplicate, so here it is argued that all source code should be freely available.

Fault-tolerant manipulation of quantum bits is demonstrated experimentally on an eight-photon cluster state using topological error correction.

The size of COPII vesicles is shown to be controlled by monoubiquitylation, with potential implications for cranio-lenticulo-sutural dysplasia and chylomicron retention disease.

Cryo-electron-microscopy reconstructions of eukaryotic and archaeal ribosomes bound by ABCE1 and Pelota suggest a conserved mechanism for ribosome recycling.

Observations of γ-rays from the Crab pulsar suggest that the energy of the pulsar wind changes from electromagnetic to kinetic over a relatively short distance close to the light cylinder of the pulsar.

The parameters critical in determining the behaviour of a fibrous medium wetted with a single liquid drop are identified as fibre flexibility, fibre geometry and drop volume.

Satellite measurements of Earth’s gravity field show that the mass loss of glaciers and ice caps contributed to sea level rise by approximately 0.4 millimetres per year between 2003 and 2010.

The conserved microRNA miR-34 regulates age-associated events and long-term brain integrity in Drosophila, providing a molecular link between ageing and neurodegeneration.

Adult muscle stem cells are used as a model system to show that the microRNA pathway, and specifically miR-489, is essential for the maintenance of the quiescent state of an adult stem-cell population by suppressing a key proliferation factor, Dek.

In a mouse model and in human medulloblastoma patients, the metastases in an individual have similar genomic alterations and DNA methylation patterns, but these patterns are highly divergent from those of the primary tumour, indicating that therapies will need to be tailored to fit the molecular alterations present in the primary tumour and/or the metastases.

A mouse model is developed in which the pro-apoptotic activity of DCC is silenced and the mice are more prone to intestinal tumour progression, giving insight into the role of DCC in human colorectal cancer.

In a mouse model of mammary carcinoma, loss of deleted in colorectal cancer (DCC) promotes metastasis formation, and in cell cultures derived from p53-deficient mouse mammary tumours DCC expression controls netrin-1-dependent cell survival, supporting the function of DCC as a context-dependent tumour suppressor that limits survival of disseminated tumour cells.

Crystal structures of menin in its free form and in complexes with MLL1 or with JUND, or with an MLL1–LEDGF heterodimer, show that menin contains a deep pocket that binds short peptides of MLL1 or JUND in the same manner, but produces opposite effects on transcription.

The X-ray crystal structure of the M2 muscarinic acetylcholine receptor, which is essential for the physiological control of cardiovascular function, is reported.

The X-ray crystal structure of the M3 muscarinic acetylcholine receptor bound to the bronchodilator drug tiotropium is reported; comparison of this structure with that of the M2 muscarinic acetylcholine receptor reveals key differences that could potentially be exploited to develop subtype-selective drugs.

A European industrial doctorate could help students to break out of academia, but applied science is not for everyone.

After finding virtual particles, a physicist turns to proteomics.

Computer love.