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Circadian rhythms

Redox redux

Oscillations in gene transcription that occur in response to biological daily clocks coordinate the physiological workings of living organisms. But turnover in cellular energy may be sufficient to make the clock tick. See Article p.498 & Letter p.554

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Figure 1: Coupling of genetic and metabolic clocks.

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J.B. declares competing financial interests. He is a speaker and consultant for Merck and for GLG; has received research awards from Amylin Pharmaceuticals and Eli Lilly and from Takeda Pharmaceuticals; and owns stock and is on the advisory board of Reset Therapeutics.

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Bass, J., Takahashi, J. Redox redux. Nature 469, 476–478 (2011). https://doi.org/10.1038/469476a

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