G-protein-coupled receptors initiate a wide range of signalling pathways in cells. It seems that both a G protein and an agonist molecule must bind to the receptors to persistently activate them. See Article p.175 & Letters p.236 & p.241
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Pierce, K. L., Premont, R. T. & Lefkowitz, R. J. Nature Rev. Mol. Cell Biol. 3, 639–650 (2002).
Rasmussen, S. G. F. et al. Nature 469, 175–180 (2011).
Rosenbaum, D. M. et al. Nature 469, 236–240 (2011).
Warne, T. et al. Nature 469, 241–244 (2011).
Rosenbaum, D. M., Rasmussen, S. G. F. & Kobilka, B. K. Nature 459, 356–363 (2009).
Park, J. H., Scheerer, P., Hofmann, K. P., Choe, H. W. & Ernst, O. P. Nature 454, 183–187 (2008).
Scheerer, P. et al. Nature 455, 497–502 (2008).
Cherezov, V. et al. Science 318, 1258–1265 (2007).
Rosenbaum, D. M. et al. Science 318, 1266–1273 (2007).
Warne, T. et al. Nature 454, 486–491 (2008).
Piscione, F. et al. J. Am. Coll. Cardiol. 52, 1381–1388 (2008).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sprang, S. Binding the receptor at both ends. Nature 469, 172–173 (2011). https://doi.org/10.1038/469172a
Published:
Issue Date:
DOI: https://doi.org/10.1038/469172a
