Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer

Entangled pathways

A medley of molecules, and the interactions between them, mediate cancer. The latest news is that the enzyme CDK8 orchestrates cross-talk between two signalling pathways that are frequently deregulated in human cancers.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Cross-talk between signalling pathways in colorectal cancer2,3.

References

  1. Clevers, H. Cell 127, 469–480 (2006).

    Article  CAS  Google Scholar 

  2. Firestein, R. et al. Nature 455, 547–551 (2008).

    Article  ADS  CAS  Google Scholar 

  3. Morris, E. J. et al. Nature 455, 552–556 (2008).

    Article  ADS  CAS  Google Scholar 

  4. Rowland, B. D. & Bernards, R. Cell 127, 871–874 (2006).

    Article  CAS  Google Scholar 

  5. Tetsu, O. & McCormick, F. Nature 398, 422–426 (1999).

    Article  ADS  CAS  Google Scholar 

  6. Horowitz, J. M. et al. Proc. Natl Acad. Sci. USA 87, 2775–2779 (1990).

    Article  ADS  CAS  Google Scholar 

  7. Hildebrandt, B. et al. Oncology 59, 344–346 (2000).

    Article  CAS  Google Scholar 

  8. Gope, R. et al. J. Natl Cancer Inst. 82, 310–314 (1990).

    Article  CAS  Google Scholar 

  9. Williams, J. P. et al. Mol. Cell Biol. 26, 1170–1182 (2006).

    Article  CAS  Google Scholar 

  10. Yamasaki, L. et al. Cell 85, 537–548 (1996).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bernards, R. Entangled pathways. Nature 455, 479–480 (2008). https://doi.org/10.1038/455479a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/455479a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing