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Volume 444 Issue 7118, 23 November 2006

Editorial

  • Presidential elections next spring are set to lend fresh impetus to research reform in France.

    Editorial

    Advertisement

  • Japan has a new prime minister, a new science adviser, and a chance to change its science policy.

    Editorial
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Research Highlights

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News

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News in Brief

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Business

  • The job of cleaning up Britain's nuclear plants is up for auction — so who might profit from the newly privatized industry? Andrea Chipman reports.

    Business
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News Feature

  • Khotso Mokhele, formerly in charge of developing research in South Africa, talks to Michael Cherry about the role that science is playing in the nation's development.

    • Michael Cherry
    News Feature
  • Philosophers since Aristotle have puzzled over the meaning of happiness. Tony Reichhardt asks what scientists, psychologists and economists can bring to the topic. Are we any closer to being able to quantify joy?

    • Tony Reichhardt
    News Feature
  • The biggest project in the history of ecology is nearing its dawn. Can its organizers pull off the seemingly impossible and unite a disparate field behind its vision to observe the ecosystems of the United States? Michael Hopkin reports.

    • Michael Hopkin
    News Feature
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Correspondence

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Books & Arts

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News & Views

  • Silicon is the archetypal semiconductor, and base material of the microelectronic age. But it turns out that, treated the right way, silicon the semiconductor can become silicon the superconductor.

    • Robert J. Cava
    News & Views
  • The first map of copy-number variation in the human genome has been created. It is now feasible to examine the role of such genome variation in disease and to explore in depth the extent of 'normal' variability.

    • Kevin V. Shianna
    • Huntington F. Willard
    News & Views
  • Accumulation of organized, self-polymerizing protein aggregates is a hallmark of Alzheimer's disease and infectious prion diseases. The similarities between these conditions may be even closer than that.

    • Roland Riek
    News & Views
  • Molecules in solution change their conformations so quickly that no method has been able to record the process. This looks set to change, as infrared spectroscopy rises to the challenge.

    • Minhaeng Cho
    News & Views
  • Generating human stem cells from a single cell recovered during preimplantation genetic diagnosis does not, in principle, harm the embryo. Can the approach be used in assisted reproductive technology programmes?

    • Joe Leigh Simpson
    News & Views
  • In most bacteria, a molecule known as trigger factor prevents misfolding of newly made proteins emerging from their ribosome factory. The dynamic action of this molecule has been followed using fluorescence spectroscopy.

    • Ada Yonath
    News & Views
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Correction

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Brief Communication

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Article

  • Last year the first map of single nucleotide changes was published; now an international consortium has mapped even larger areas of differences, called copy number variants. These variants are at least 1,000-base-pair differences between individual people, and have been linked to both benign and disease-causing changes in the human genome.

    • Richard Redon
    • Shumpei Ishikawa
    • Matthew E. Hurles
    Article
  • Fluorescently labelling trigger factor (TF) to monitor its real-time interaction with ribosome and polypeptide reveals that binding to the ribosome opens and activates TF. Rather than remaining bound to the ribosome, TF is carried away from it on the new polypeptide chain and remains associated with it for a time that depends on the propensity of the protein to aggregate.

    • Christian M. Kaiser
    • Hung-Chun Chang
    • José M. Barral
    Article
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Letter

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Addendum

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Erratum

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Corrigendum

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Prospects

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Special Report

  • Nanobiotechnology is a growing field, but will it emulate the biotech boom? Virginia Gewin investigates.

    • Virginia Gewin
    Special Report
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Movers

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Recruiters and Academia

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Graduate Journal

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Futures

  • A rose by any other name.

    • Michael Garrett Farrelly
    Futures
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Authors

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Brief Communications Arising

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Corrigendum

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