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The case for a US prospective cohort study of genes and environment

Abstract

Information from the Human Genome Project will be vital for defining the genetic and environmental factors that contribute to health and disease. Well-designed case–control studies of people with and without a particular disease are essential for this, but rigorous and unbiased conclusions about the causes of diseases and their population-wide impact will require a representative population to be monitored over time (a prospective cohort study). The time is right for the United States to consider such a project.

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References

  1. International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature 409, 860–921 (2001).

  2. Venter, J. C. et al. The sequence of the human genome. Science 291, 1304–1351 (2001).

    ADS  CAS  PubMed  Google Scholar 

  3. The International HapMap Consortium. The International HapMap Project. Nature 426, 789–796 (2003).

  4. Shi, M. M. Technologies for individual genotyping: detection of genetic polymorphisms in drug targets and disease genes. Am. J. Pharmacogenomics 2, 197–205 (2002).

    Article  CAS  PubMed  Google Scholar 

  5. Weaver, V. M., Buckley, T. J. & Groopman, J. D. Approaches to environmental exposure assessment in children. Environ. Health Perspect. 106 (suppl. 3), 827–832 (1998).

    PubMed  PubMed Central  Google Scholar 

  6. Chakravarti, A. & Little, P. Nature, nurture and human disease. Nature 421, 412–414 (2003).

    Article  ADS  PubMed  Google Scholar 

  7. van den Oord, E. Method to detect genotype–environment interactions for quantitative trait loci in association studies. Am. J. Epidemiol. 150, 1179–1187 (1999).

    Article  CAS  PubMed  Google Scholar 

  8. Gordis, L. Epidemiology 2nd edn (W. B. Saunders & Co., Philadelphia, 2000).

    Google Scholar 

  9. Pritchard, J. K., Stephens, M., Rosenberg, N. A. & Donnelly, P. Association mapping in structured populations. Am. J. Hum. Genet. 67, 170–181 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Guo, S. W. Inflation of sibling recurrence-risk ratio, due to ascertainment bias and/or overreporting. Am. J. Hum. Genet. 63, 252–258 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Feinstein, A. R. Experimental requirements and scientific principles in case-control studies. J. Chronic Dis. 38, 127–133 (1985).

    Article  CAS  PubMed  Google Scholar 

  12. Silberberg, J. S., Wlodarczyk, J., Fryer, J., Ray, C. D. & Hensley, M. J. Correction for biases in a population-based study of family history and coronary heart disease. The Newcastle Family History Study I. Am. J. Epidemiol. 147, 1123–1132 (1998).

    Article  CAS  PubMed  Google Scholar 

  13. Clayton, D. & McKeigue, P. M. Epidemiological methods for studying genes and environmental factors in complex diseases. Lancet 358, 1356–1360 (2001).

    Article  CAS  PubMed  Google Scholar 

  14. Hill, A. B. The environment and disease: association or causation? Proc. R. Soc. Med. 58, 295–300 (1965).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

Appreciation is expressed for comments on the manuscript from J. Bailey-Wilson, W. Burke, M. Boehnke, B. Foxman, A. Guttmacher, E. Lander, T. Manolio, A. Wilson and E. Zerhouni. The opinions expressed in this Commentary are those of the author, and do not represent an official position of the National Human Genome Research Institute, the National Institutes of Health or the Department of Health and Human Services.

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Collins, F. The case for a US prospective cohort study of genes and environment. Nature 429, 475–477 (2004). https://doi.org/10.1038/nature02628

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