Table of contents

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Human genomes, public and private p745

The burgeoning commercial sector that is based on genome information poses a challenge to the norms of scientific publication. But it remains to be established that the conditions of access to published sequence data need to change.




Publication of human genomes sparks fresh sequence debate p747

Declan Butler


And now for the proteome. . . p747

Alison Abbott


Call for tighter controls on transgenic foods p749

David Spurgeon


Physicists worried by grant reforms p749

David Adam


Reforms woo scientists from mainland China p750

David Cyranoski


France and Spain join forces over synchrotron project p750

Xavier Bosch


Indian company offers cheap anti-AIDS drugs p751

David Dickson


Fears grow over melting permafrost p751

Quirin Schiermeier


news in brief p752



news feature

Back in business p754

The focus of activity in high-energy physics is about to switch from CERN, near Geneva, to Fermilab in Illinois. Sarah Tomlin sampled the atmosphere, as excited physicists prepared their Tevatron accelerator for action.

Sarah Tomlin


What a long, strange trip it's been. . . p756

The draft human genome sequence published in Nature this week is the culmination of 15 years of work, involving 20 sequencing centres in six countries. Here, we present a reminder of some of the key moments.


Are you ready for the revolution? p758

If biologists do not adapt to the powerful computational tools needed to exploit huge data sets, says Declan Butler, they could find themselves floundering in the wake of advances in genomics.

Declan Butler




Skilled eyes are needed to go on studying the richness of the soil p761

Henri Andre, Xavier Ducarme, Jo Anderson, David Crossley Jr, Hartmut Koehler, Maurizio Paoletti, David Walter & Philippe Lebrun

Astronomy network will allow every site to shine p761

Roland Gredel & Rene Rutten

Semmelweis and the battle against infection p761

George Redei



Patents in a genetic age p763

The present patent system risks becoming a barrier to medical progress.



Book Reviews

The road to the code. . .and the cast who brought genetics to centre stage p765

Jan A. Witkowski reviews Cracking the Genome: Inside the Race to Unlock Human DNA/The Sequence: Inside the Race for the Human Genome by Kevin Davies


Affairs of the heartless p766

Lewis Pyenson reviews Einstein in Love: A Scientific Romance by Dennis Overbye


An excavation of the drug myth p767

Leslie Iversen reviews Intoxicating Minds by Ciaran Regan


One who created a tempo of his own p768

Michael J. Novacek reviews George Gaylord Simpson: Paleontologist and Evolutionist by Leo F. Laporte




Talking about the genome p769

Biologists must take responsibility for the correct use of language in genetics.

Horace Freeland Judson




The beanbag lives on p771

James F. Crow



News and Views

Polymer science: A material fix p773

The idea of materials that can mend themselves seems far-fetched. But a system that allows composite materials to 'self-heal' has been devised and has passed some early tests.

Richard P. Wool


Quantum physics: Count them all p774

Direct experimental evidence to resolve the conflict between classical and quantum physics has been a long-awaited goal. As the last loophole closes, it seems that quantum mechanics was right all along.

Philippe Grangier


Ecology: The rising cost of bushmeat p775

Some plants depend on specific animal vectors for the dispersal of their seeds. If the vector comes under threat, there are likely to be adverse consequences for the plant.

Peter D. Moore


Biochemistry: Single-handed cooperation p777

Our bodies use only 'left-handed' amino acids and 'right-handed' sugars. Hints are now emerging on how this handedness evolved and how cooperativity among like-handed molecular components came about.

Jay S. Siegel


100 and 50 years ago p777


Medicine: Channel fault in osteopetrosis p778

Amanda Tromans


Obituary: Konrad E. Bloch (1912–2000) p779

Howard Goldfine & Dennis E. Vance



Brief Communications

Growth of domesticated transgenic fish p781

A growth-hormone transgene boosts the size of wild but not domesticated trout.

Robert H. Devlin, Carlo A. Biagi, Timothy Y. Yesaki, Duane E. Smailus & John C. Byatt


Cavitation science: Is there a simple theory of sonoluminescence? p782

S. Putterman, P. G. Evans, G. Vazquez & K. Weninger


Cavitation science: Is there a simple theory of sonoluminescence? p783

S. Hilgenfeldt, S. Grossmann & D. Lohse


Genetic imprinting: Urinary odour preferences in mice p783

Anthony R. Isles, Michael J. Baum, Dan Ma, Eric B. Keverne & Nicholas D. Allen


Erratum: Watching fights raises fish hormone levels p784




Nuclear fission modes and fragment mass asymmetries in a five-dimensional deformation space p785

P. Möller, D. G. Madland, A. J. Sierk & A. Iwamoto



Letters to Nature

Experimental violation of a Bell's inequality with efficient detection p791

M. A. Rowe, D. Kielpinski, V. Meyer, C. A. Sackett, W. M. Itano, C. Monroe & D. J. Wineland


Autonomic healing of polymer composites p794

S. R. White, N. R. Sottos, P. H. Geubelle, J. S. Moore, M. R. Kessler, S. R. Sriram, E. N. Brown & S. Viswanathan


A chiroselective peptide replicator p797

Alan Saghatelian, Yohei Yokobayashi, Kathy Soltani & M. Reza Ghadiri


Evidence for non-selective preservation of organic matter in sinking marine particles p801

John I. Hedges, Jeffrey A. Baldock, Yves Gélinas, Cindy Lee, Michael Peterson & Stuart G. Wakeham


Interhemispheric climate links revealed by a late-glacial cooling episode in southern Chile p804

Patricio I. Moreno, George L. Jacobson, Jr, Thomas V. Lowell & George H. Denton


Evidence of recent volcanic activity on the ultraslow-spreading Gakkel ridge p808

M. H. Edwards, G. J. Kurras, M. Tolstoy, D. R. Bohnenstiehl, B. J. Coakley & J. R. Cochran



Human Genome


Everyone's genome p813


news and views

Our genome unveiled p814

The draft sequences of the human genome are remarkable achievements. They provide an outline of the information needed to create a human being and show, for the first time, the overall organization of a vertebrate's DNA.

David Baltimore


Genome speak p815

Peer Bork & Richard Copley


The maps: Clone by clone by clone p816

The public project's sequencing strategy involved producing a map of the human genome, and then pinning sequence to it. This helps to avoid errors in the sequence, especially in repetitive regions.

Maynard V. Olson


The draft sequences: Filling in the gaps p818

Two rough drafts of the human genome sequence are now published. Completion of the sequences lies ahead, but the implications for studying human diseases and for biotechnology are already profound.

Peer Bork & Richard Copley


The draft sequences: Comparing species p820

Comparing the human genome sequences with those of other species will not only reveal what makes us genetically different. It may also help us understand what our genes do.

Gerald M. Rubin


Single nucleotide polymorphisms: From the evolutionary past. . . p821

Single nucleotide polymorphisms are the bread-and-butter of DNA sequence variation. They provide a rich source of information about the evolutionary history of human populations.

Mark Stoneking


Single nucleotide polymorphisms: . . .to a future of genetic medicine p822

Single base differences between human genomes underlie differences in susceptibility to, or protection from, a host of diseases. Hence the great potential of such information in medicine.

Aravinda Chakravarti



Guide to the draft human genome p824

Tyra G. Wolfsberg, Johanna McEntyre & Gregory D. Schuler


Mining the draft human genome p827

Ewan Birney, Alex Bateman, Michele E. Clamp & Tim J. Hubbard


Keeping time with the human genome p829

Jonathan D. Clayton, Charalambos P. Kyriacou & Steven M. Reppert


Expressing the human genome p832

Rossella Tupler, Giovanni Perini & Michael R. Green


Learning about addiction from the genome p834

Eric J. Nestler & David Landsman


A genomic view of immunology p836

Aude M. Fahrer, J. Fernando Bazan, Peter Papathanasiou, Keats A. Nelms & Christopher C. Goodnow


A genomic perspective on membrane compartment organization p839

Jason B. Bock, Hugo T. Matern, Andrew A. Peden & Richard H. Scheller


Genomics, the cytoskeleton and motility p842

Thomas D. Pollard


Can sequencing shed light on cell cycling? p844

Andrew W. Murray & Debora Marks


Evolutionary analyses of the human genome p847

Wen-Hsiung Li, Zhenglong Gu, Haidong Wang & Anton Nekrutenko


Cancer and genomics p850

P. Andrew Futreal, Arek Kasprzyk, Ewan Birney, James C. Mullikin, Richard Wooster & Michael R. Stratton


Human disease genes p853

Gerardo Jimenez-Sanchez, Barton Childs & David Valle


Computational comparison of two draft sequences of the human genome p856

John Aach, Martha L. Bulyk, George M. Church, Jason Comander, Adnan Derti & Jay Shendure



Initial sequencing and analysis of the human genome p860

International Human Genome Sequencing Consortium Eric S. Lander, Lauren M. Linton, Bruce Birren, Chad Nusbaum, Michael C. Zody, Jennifer Baldwin, Keri Devon, Ken Dewar, Michael Doyle, William FitzHugh, Roel Funke, Diane Gage, Katrina Harris, Andrew Heaford, John Howland, Lisa Kann, Jessica Lehoczky, Rosie LeVine, Paul McEwan, Kevin McKernan, James Meldrim, Jill P. Mesirov, Cher Miranda, William Morris, Jerome Naylor, Christina Raymond, Mark Rosetti, Ralph Santos, Andrew Sheridan, Carrie Sougnez, Nicole Stange-Thomann, Nikola Stojanovic, Aravind Subramanian & Dudley Wyman for Whitehead Institute for Biomedical Research, Center for Genome Research:, Jane Rogers, John Sulston, Rachael Ainscough, Stephan Beck, David Bentley, John Burton, Christopher Clee, Nigel Carter, Alan Coulson, Rebecca Deadman, Panos Deloukas, Andrew Dunham, Ian Dunham, Richard Durbin, Lisa French, Darren Grafham, Simon Gregory, Tim Hubbard, Sean Humphray, Adrienne Hunt, Matthew Jones, Christine Lloyd, Amanda McMurray, Lucy Matthews, Simon Mercer, Sarah Milne, James C. Mullikin, Andrew Mungall, Robert Plumb, Mark Ross, Ratna Shownkeen & Sarah Sims for The Sanger Centre:, Robert H. Waterston, Richard K. Wilson, LaDeana W. Hillier, John D. McPherson, Marco A. Marra, Elaine R. Mardis, Lucinda A. Fulton, Asif T. Chinwalla, Kymberlie H. Pepin, Warren R. Gish, Stephanie L. Chissoe, Michael C. Wendl, Kim D. Delehaunty, Tracie L. Miner, Andrew Delehaunty, Jason B. Kramer, Lisa L. Cook, Robert S. Fulton, Douglas L. Johnson, Patrick J. Minx & Sandra W. Clifton for Washington University Genome Sequencing Center, Trevor Hawkins, Elbert Branscomb, Paul Predki, Paul Richardson, Sarah Wenning, Tom Slezak, Norman Doggett, Jan-Fang Cheng, Anne Olsen, Susan Lucas, Christopher Elkin, Edward Uberbacher & Marvin Frazier for US DOE Joint Genome Institute:, Richard A. Gibbs, Donna M. Muzny, Steven E. Scherer, John B. Bouck, Erica J. Sodergren, Kim C. Worley, Catherine M. Rives, James H. Gorrell, Michael L. Metzker, Susan L. Naylor, Raju S. Kucherlapati, David L. Nelson & George M. Weinstock for Baylor College of Medicine Human Genome Sequencing Center:, Yoshiyuki Sakaki, Asao Fujiyama, Masahira Hattori, Tetsushi Yada, Atsushi Toyoda, Takehiko Itoh, Chiharu Kawagoe, Hidemi Watanabe, Yasushi Totoki & Todd Taylor for RIKEN Genomic Sciences Center:, Jean Weissenbach, Roland Heilig, William Saurin, Francois Artiguenave, Philippe Brottier, Thomas Bruls, Eric Pelletier, Catherine Robert & Patrick Wincker for Genoscope and CNRS UMR-8030:, André Rosenthal, Matthias Platzer, Gerald Nyakatura, Stefan Taudien & Andreas Rump for Department of Genome Analysis, Institute of Molecular Biotechnology:, Douglas R. Smith, Lynn Doucette-Stamm, Marc Rubenfield, Keith Weinstock, Hong Mei Lee & JoAnn Dubois for GTC Sequencing Center:, Huanming Yang, Jun Yu, Jian Wang, Guyang Huang & Jun Gu for Beijing Genomics Institute/Human Genome Center:, Leroy Hood, Lee Rowen, Anup Madan & Shizen Qin for Multimegabase Sequencing Center, The Institute for Systems Biology:, Ronald W. Davis, Nancy A. Federspiel, A. Pia Abola & Michael J. Proctor for Stanford Genome Technology Center:, Bruce A. Roe, Feng Chen & Huaqin Pan for University of Oklahoma's Advanced Center for Genome Technology:, Juliane Ramser, Hans Lehrach & Richard Reinhardt for Max Planck Institute for Molecular Genetics:, W. Richard McCombie, Melissa de la Bastide & Neilay Dedhia for Cold Spring Harbor Laboratory, Lita Annenberg Hazen Genome Center:, Helmut Blöcker, Klaus Hornischer & Gabriele Nordsiek for GBF—German Research Centre for Biotechnology:, Richa Agarwala, L. Aravind, Jeffrey A. Bailey, Alex Bateman, Serafim Batzoglou, Ewan Birney, Peer Bork, Daniel G. Brown, Christopher B. Burge, Lorenzo Cerutti, Hsiu-Chuan Chen, Deanna Church, Michele Clamp, Richard R. Copley, Tobias Doerks, Sean R. Eddy, Evan E. Eichler, Terrence S. Furey, James Galagan, James G. R. Gilbert, Cyrus Harmon, Yoshihide Hayashizaki, David Haussler, Henning Hermjakob, Karsten Hokamp, Wonhee Jang, L. Steven Johnson, Thomas A. Jones, Simon Kasif, Arek Kaspryzk, Scot Kennedy, W. James Kent, Paul Kitts, Eugene V. Koonin, Ian Korf, David Kulp, Doron Lancet, Todd M. Lowe, Aoife McLysaght, Tarjei Mikkelsen, John V. Moran, Nicola Mulder, Victor J. Pollara, Chris P. Ponting, Greg Schuler, Jörg Schultz, Guy Slater, Arian F. A. Smit, Elia Stupka, Joseph Szustakowki, Danielle Thierry-Mieg, Jean Thierry-Mieg, Lukas Wagner, John Wallis, Raymond Wheeler, Alan Williams, Yuri I. Wolf, Kenneth H. Wolfe, Shiaw-Pyng Yang & Ru-Fang Yeh for *Genome Analysis Group (listed in alphabetical order, also includes individuals listed under other headings):, Francis Collins, Mark S. Guyer, Jane Peterson, Adam Felsenfeld & Kris A. Wetterstrand for Scientific management: National Human Genome Research Institute, US National Institutes of Health:, Richard M. Myers, Jeremy Schmutz, Mark Dickson, Jane Grimwood & David R. Cox for Stanford Human Genome Center:, Maynard V. Olson, Rajinder Kaul & Christopher Raymond for University of Washington Genome Center:, Nobuyoshi Shimizu, Kazuhiko Kawasaki & Shinsei Minoshima for Department of Molecular Biology, Keio University School of Medicine:, Glen A. Evans, Maria Athanasiou & Roger Schultz for University of Texas Southwestern Medical Center at Dallas:, Aristides Patrinos for Office of Science, US Department of Energy: & Michael J. Morgan for The Wellcome Trust:


Experimental annotation of the human genome using microarray technology p922

D. D. Shoemaker, E. E. Schadt, C. D. Armour, Y. D. He, P. Garrett-Engele, P. D. McDonagh, P. M. Loerch, A. Leonardson, P. Y. Lum, G. Cavet, L. F. Wu, S. J. Altschuler, S. Edwards, J. King, J. S. Tsang, G. Schimmack, J. M. Schelter, J. Koch, M. Ziman, M. J. Marton, B. Li, P. Cundiff, T. Ward, J. Castle, M. Krolewski, M. R. Meyer, M. Mao, J. Burchard, M. J. Kidd, H. Dai, J. W. Phillips, P. S. Linsley, R. Stoughton, S. Scherer & M. S. Boguski


A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms p928

The International SNP Map Working Group(contributing institutions are listed alphabetically). Ravi Sachidanandam, David Weissman, Steven C. Schmidt, Jerzy M. Kakol & Lincoln D. Stein for Cold Spring Harbor Laboratories:, Gabor Marth & Steve Sherry for National Center for Biotechnology Information:, James C. Mullikin, Beverley J. Mortimore, David L. Willey, Sarah E. Hunt, Charlotte G. Cole, Penny C. Coggill, Catherine M. Rice, Zemin Ning, Jane Rogers & David R. Bentley for The Sanger Centre:, Pui-Yan Kwok, Elaine R. Mardis, Raymond T. Yeh, Brian Schultz, Lisa Cook, Ruth Davenport, Michael Dante, Lucinda Fulton, LaDeana Hillier, Robert H. Waterston & John D. McPherson for Washington University in St. Louis: & Brian Gilman, Stephen Schaffner, William J. Van Etten, David Reich, John Higgins, Mark J. Daly, Brendan Blumenstiel, Jennifer Baldwin, Nicole Stange-Thomann, Michael C. Zody, Lauren Linton, Eric S. Lander & David Altshuler for Whitehead/MIT Center for Genome Research:


A physical map of the human genome p934

The International Human Genome Mapping ConsortiumJohn D. McPherson, Marco Marra, LaDeana Hillier, Robert H. Waterston, Asif Chinwalla, John Wallis, Mandeep Sekhon, Kristine Wylie, Elaine R. Mardis, Richard K. Wilson, Robert Fulton, Tamara A. Kucaba, Caryn Wagner-McPherson & William B. Barbazuk for Washington University School of Medicine, Genome Sequencing Center:, Simon G. Gregory, Sean J. Humphray, Lisa French, Richard S. Evans, Graeme Bethel, Adam Whittaker, Jane L. Holden, Owen T. McCann, Andrew Dunham, Carol Soderlund, Carol E. Scott & David R. Bentley for Wellcome Trust Genome Campus:, Gregory Schuler, Hsiu-Chuan Chen & Wonhee Jang for National Center for Biotechnology Information:, Eric D. Green, Jacquelyn R. Idol & Valerie V. Braden Maduro for National Human Genome Research Insititute:, Kate T. Montgomery, Eunice Lee, Ashley Miller, Suzanne Emerling & Raju Kucherlapati for Albert Einstein College of Medicine:, Richard Gibbs, Steve Scherer, J. Harley Gorrell, Erica Sodergren, Kerstin Clerc-Blankenburg, Paul Tabor, Susan Naylor & Dawn Garcia for Baylor College of Medicine, Human Genome Sequencing Center:, Pieter J. de Jong, Joseph J. Catanese, Norma Nowak & Kazutoyo Osoegawa for Roswell Park Cancer Institute:, Shizhen Qin, Lee Rowen, Anuradha Madan, Monica Dors & Leroy Hood for Multimegabase Sequencing Center:, Barbara Trask, Cynthia Friedman & Hillary Massa for Fred Hutchinson Cancer Research Institute:, Vivian G. Cheung, Ilan R. Kirsch, Thomas Reid & Raluca Yonescu for The Children's Hospital of Philadelphia:, Jean Weissenbach, Thomas Bruls & Roland Heilig for Genoscope:, Elbert Branscomb, Anne Olsen, Norman Doggett, Jan-Fang Cheng & Trevor Hawkins for US DOE Joint Genome Institute:, Richard M. Myers, Jin Shang, Lucia Ramirez, Jeremy Schmutz, Olivia Velasquez, Kami Dixon, Nancy E. Stone & David R. Cox for Stanford Human Genome Center and Department of Genetics:, David Haussler, W. James Kent, Terrence Furey, Sanja Rogic & Scot Kennedy for University of California, Santa Cruz:, Steven Jones for British Columbia Cancer Research Centre:, André Rosenthal, Gaiping Wen, Markus Schilhabel, Gernot Gloeckner, Gerald Nyakatura, Reiner Siebert & Brigitte Schlegelberger for Department of Genome Analysis, Institute of Molecular Biotechnology:, Julie Korenberg & Xiao-Ning Chen for Departments of Human Genetics and Pediatrics, University of California:, Asao Fujiyama, Masahira Hattori, Atsushi Toyoda, Tetsushi Yada, Hong-Seok Park & Yoshiyuki Sakaki for RIKEN Genomic Sciences Center:, Nobuyoshi Shimizu, Shuichi Asakawa, Kazuhiko Kawasaki, Takashi Sasaki, Ai Shintani, Atsushi Shimizu, Kazunori Shibuya, Jun Kudoh & Shinsei Minoshima for Department of Molecular Biology, Keio University School of Medicine: & Juliane Ramser, Peter Seranski, Celine Hoff, Annemarie Poustka, Richard Reinhardt & Hans Lehrach for Max-Planck-Institute for Molecular Genetics:


letter to nature

The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X p942

D. R. Bentley, P. Deloukas, A. Dunham, L. French, S. G. Gregory, S. J. Humphray, A. J. Mungall, M. T. Ross, N. P. Carter, I. Dunham, C. E. Scott, K. J. Ashcroft, A. L. Atkinson, K. Aubin, D. M. Beare, G. Bethel, N. Brady, J. C. Brook, D. C. Burford, W. D. Burrill, C. Burrows, A. P. Butler, C. Carder, J. J. Catanese, C. M. Clee, S. M. Clegg, V. Cobley, A. J. Coffey, C. G. Cole, J. E. Collins, J. S. Conquer, R. A. Cooper, K. M. Culley, E. Dawson, F. L. Dearden, R. M. Durbin, P. J. de Jong, P. D. Dhami, M. E. Earthrowl, C. A. Edwards, R. S. Evans, C. J. Gillson, J. Ghori, L. Green, R. Gwilliam, K. S. Halls, S. Hammond, G. L. Harper, R. W. Heathcott, J. L. Holden, E. Holloway, B. L. Hopkins, P. J. Howard, G. R. Howell, E. J. Huckle, J. Hughes, P. J. Hunt, S. E. Hunt, M. Izmajlowicz, C. A. Jones, S. S. Joseph, G. Laird, C. F. Langford, M. H. Lehvaslaiho, M. A. Leversha, O. T. McCann, L. M. McDonald, J. McDowall, G. L. Maslen, D. Mistry, N. K. Moschonas, V. Neocleous, D. M. Pearson, K. J. Phillips, K. M. Porter, S. R. Prathalingam, Y. H. Ramsey, S. A. Ranby, C. M. Rice, J. Rogers, L. J. Rogers, T. Sarafidou, D. J. Scott, G. J. Sharp, C. J. Shaw-Smith, L. J. Smink, C. Soderlund, E. C. Sotheran, H. E. Steingruber, J. E. Sulston, A. Taylor, R. G. Taylor, A. A. Thorpe, E. Tinsley, G. L. Warry, A. Whittaker, P. Whittaker, S. H. Williams, T. E. Wilmer, R. Wooster & C. L. Wright


A physical map of the human Y chromosome p943

Charles A. Tilford, Tomoko Kuroda-Kawaguchi, Helen Skaletsky, Steve Rozen, Laura G. Brown, Michael Rosenberg, John D. McPherson, Kristine Wylie, Mandeep Sekhon, Tamara A. Kucaba, Robert H. Waterston & David C. Page


A high-resolution map of human chromosome 12 p945

Kate T. Montgomery, Eunice Lee, Ashley Miller, Stephanie Lau, Cecilia Shim, Jeremy Decker, Denise Chiu, Suzanne Emerling, Mandeep Sekhon, Rachel Kim, Jack Lenz, Jinghua Han, Ilya Ioshikhes, Beatrice Renault, Ivonne Marondel, Sung-Joo Kim Yoon, Kyuyoung Song, V. V. V. S. Murty, Steven Scherer, Raluca Yonescu, Ilan R. Kirsch, Thomas Ried, John McPherson, Richard Gibbs & Raju Kucherlapati


A physical map of human chromosome 14 p947

Thomas Brüls, Gabor Gyapay, Jean-Louis Petit, François Artiguenave, Virginie Vico, Shizen Qin, Aye Mon Tin-Wollam, Corinne Da Silva, Delphine Muselet, Delphine Mavel, Eric Pelletier, Michael Levy, Asao Fujiyama, Fumihiko Matsuda, Richard Wilson, Lee Rowen, Leroy Hood, Jean Weissenbach, William Saurin & Roland Heilig


Integration of telomere sequences with the draft human genome sequence p948

H. C. Riethman, Z. Xiang, S. Paul, E. Morse, X.-L. Hu, J. Flint, H.-C. Chi, D. L. Grady & R. K. Moyzis


Comparison of human genetic and sequence-based physical maps p951

Adong Yu, Chengfeng Zhao, Ying Fan, Wonhee Jang, Andrew J. Mungall, Panos Deloukas, Anne Olsen, Norman A. Doggett, Nader Ghebranious, Karl W. Broman & James L. Weber


Integration of cytogenetic landmarks into the draft sequence of the human genome p953

The BAC Resource Consortium, V. G. Cheung, N. Nowak, W. Jang, I. R. Kirsch, S. Zhao, X.-N. Chen, T. S. Furey, U.-J. Kim, W.-L. Kuo, M. Olivier, J. Conroy, A. Kasprzyk, H. Massa, R. Yonescu, S. Sait, C. Thoreen, A. Snijders, E. Lemyre, J. A. Bailey, A. Bruzel, W. D. Burrill, S. M. Clegg, S. Collins, P. Dhami, C. Friedman, C. S. Han, S. Herrick, J. Lee, A. H. Ligon, S. Lowry, M. Morley, S. Narasimhan, K. Osoegawa, Z. Peng, I. Plajzer-Frick, B. J. Quade, D. Scott, K. Sirotkin, A. A. Thorpe, J. W. Gray, J. Hudson, D. Pinkel, T. Ried, L. Rowen, G. L. Shen-Ong, R. L. Strausberg, E. Birney, D. F. Callen, J.-F. Cheng, D. R. Cox, N. A. Doggett, N. P. Carter, E. E. Eichler, D. Haussler, J. R. Korenberg, C. C. Morton, D. Albertson, G. Schuler, P. J. de Jong & B. J. Trask


New on the Market

Microarrays, DNA and RNA prep p959

Genomics — touched upon elsewhere in the issue — sneaks in here too.



Careers and Recruitment

Labs and companies seek their niches as work continues after the draft p961

Specialization may be the key to success as divisions between big and small genomics centres continue to grow, say Potter Wickware and Paul Smaglik.

Potter Wickware & Paul Smaglik


Following the growth of data p961

Potter Wickware


Current role suggests the shape of future work opportunities p963

Helen Gavaghan


Who makes the best bioinformaticians? p963

Paul Smaglik


Tips for sequence centre job-seekers p964

Helen Gavaghan


Biology moves into the silicon stage p964

Helen Gavaghan


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