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A nuclear 'fossil' of the mitochondrial D-loop and the origin of modern humans

Nature volume 378, pages 489–492 (1995)Cite this article

Abstract

MAMMALIAN mitochondria! DNA sequences evolve more rapidly than nuclear sequences1. Although the rapid rate of evolution is an advantage for the study of closely related species and populations, it presents a problem in situations where related species, used as outgroups in phylogenetic analyses, have accumulated so much change that multiple substitutions obliterate the phylogenetic information2. However, mitochondrial DNA sequences are frequently inserted into the nuclear genome3, where they presumably evolve as nuclear pseudogene sequences and therefore more slowly than their mitochondria! counterparts. Such sequences thus represent molecular 'fossils' that could shed light on the evolution of the mitochondrial genome and could be used as outgroups in situations where no appropriate outgroup species exist. Here we show that human chromosome 11 carries a recent integration of the mitochondrial control region that can be used to gain further insight into the origin of the human mitochondrial gene pool.

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Authors and Affiliations

  1. Zoologisches Institut der Universität München, PO Box 202136, D-80021, München, Germany

    Hans Zischler, Helga Geisert, Arndt von Haeseler & Svante Pääbo

Authors
  1. Hans Zischler
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  2. Helga Geisert
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  3. Arndt von Haeseler
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  4. Svante Pääbo
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Zischler, H., Geisert, H., von Haeseler, A. et al. A nuclear 'fossil' of the mitochondrial D-loop and the origin of modern humans. Nature 378, 489–492 (1995). https://doi.org/10.1038/378489a0

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