Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

Nature volume 364, pages 501–506 (1993)Cite this article

Abstract

Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role in vivo, mice homozygous for a targeted mutation in the myogenin gene were generated. These mice survive fetal development but die immediately after birth and show a severe reduction of all skeletal muscle. Myogenin-mutant mice differ from mice carrying mutations in genes for the related myogenic factors Myf5 and MyoD, which have no muscle defects. Myogenin is therefore essential for the development of functional skeletal muscle.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Olson, E. N. Genes Dev. 4, 1454–1461 (1990).

    Article  CAS  Google Scholar 

  2. Weintraub, H. et al. Science 251, 761–766 (1991).

    Article  ADS  CAS  Google Scholar 

  3. Buckingham, M. Trends Genet. 8, 144–148 (1992).

    Article  CAS  Google Scholar 

  4. Wright, W. E. Curr. Opin. genet. Dev. 2, 243–248 (1992).

    Article  CAS  Google Scholar 

  5. Braun, T., Rudnicki, M. A., Arnold, H.-H. & Jaenisch, R. Cell 71, 369–382 (1992).

    Article  CAS  Google Scholar 

  6. Rudnicki, M. A., Braun, T., Hinuma, S. & Jaenisch, R. Cell 71, 383–390 (1992).

    Article  CAS  Google Scholar 

  7. Ott, M.-O., Bober, E., Lyons, G., Arnold, H.-H. & Buckingham, M. Development 111, 1097–1107 (1991).

    CAS  PubMed  Google Scholar 

  8. Wright, W. E., Sassoon, D. A. & Lin, V. K. Cell 56, 607–617 (1989).

    Article  CAS  Google Scholar 

  9. Sassoon, D. et al. Nature 341, 303–307 (1989).

    Article  ADS  CAS  Google Scholar 

  10. Hinterberger, T. J., Sassoon, D. A., Rhodes, S. J. & Konieczny, S. F. Devl Biol. 147, 144–156 (1991).

    Article  CAS  Google Scholar 

  11. Bober, E. et al. J. Cell Biol. 113, 1255–1265 (1991).

    Article  CAS  Google Scholar 

  12. Edmondson, D. G. & Olson, E. N. Genes Dev. 3, 628–640 (1989).

    Article  CAS  Google Scholar 

  13. Brunetti, A. & Goldfine, I. D. Molec. Endocr. 4, 880–885 (1990).

    Article  CAS  Google Scholar 

  14. Florini, J. R. & Ewton, D. Z. J. biol. Chem. 265, 13435–13437 (1990).

    CAS  PubMed  Google Scholar 

  15. Olson, E. N. et al. Genomics 8, 427–434 (1990).

    Article  CAS  Google Scholar 

  16. Edmondson, D. G., Cheng, T. C., Cserjesi, P., Chakraborty, T. & Olson, E. N. Molec. cell. Biol. 12, 3665–3677 (1992).

    Article  CAS  Google Scholar 

  17. Mansour, S. L., Thomas, K. R. & Capecchi, M. R. Nature 338, 348–352 (1988).

    Article  ADS  Google Scholar 

  18. McMahon, A. P. & Bradley, A. Cell 62, 1073–1085 (1990).

    Article  CAS  Google Scholar 

  19. Wright, W. E., Binder, M. & Funk, W. Molec. cell. Biol. 11, 4104–4110 (1991).

    Article  CAS  Google Scholar 

  20. Chen, J. M. J. Anat., London 86, 373–386 (1952).

    CAS  Google Scholar 

  21. Chen, J. M. J. Anat., London 87, 130–149 (1953).

    CAS  Google Scholar 

  22. Chakraborty, T. & Olson, E. N. Molec. cell. Biol. 11, 6103–6108 (1991).

    Article  CAS  Google Scholar 

  23. Cheng, T. C., Hanley, T. A., Mudd, J., Merlie, J. P. & Olson, E. N. J. Cell Biol. 119, 1649–1656 (1992).

    Article  CAS  Google Scholar 

  24. Cheng, T.-C., Wallace, M., Merlie, J. P. & Olson, E. N. Science 261, 215–218 (1993).

    Article  ADS  CAS  Google Scholar 

  25. Schwarz, J. J., Chakraborty, T., Martin, J., Zhou, J. & Olson, E. N. Molec. cell. Biol. 12, 266–275 (1992).

    Article  CAS  Google Scholar 

  26. Ramirez-Solis, R. et al. Analyt. Biochem. 201, 331–335 (1992).

    Article  CAS  Google Scholar 

  27. Li, L. et al. Cell 71, 1181–1194 (1992).

    Article  CAS  Google Scholar 

  28. McLeod, M. J. Teratology 22, 299–301 (1980).

    Article  CAS  Google Scholar 

  29. Chomczynski, P. & Sacchi, N. Analyt. Biochem. 162, 156–159 (1987).

    Article  CAS  Google Scholar 

  30. Buskin, J. N., Jaynes, J. B., Chamberlain, J. S. & Hauschka, S. D. J. molec. Evol. 22, 334–341 (1985).

    Article  ADS  CAS  Google Scholar 

  31. Medford, R. M., Wydon, R. M., Nguyen, H. T. & Nadal-Ginard, B. Proc. natn. Acad. Sci. U.S.A. 77, 5749–5753 (1980).

    Article  ADS  CAS  Google Scholar 

  32. Isenberg, K. E., Mudd, J., Shah, V. & Merlie, J. P. Nucleic Acids Res. 14, 5111 (1986).

    Article  CAS  Google Scholar 

  33. Yu, L., LaPolla, R. J. & Davidson, N. Nucleic Acids Res. 14, 3539–3555 (1986).

    Article  CAS  Google Scholar 

  34. LaPolla, R. D., Mayne, K. M. & Davidson, N. Proc. natn. Acad. Sci. U.S.A. 81, 7970–7974 (1984).

    Article  ADS  CAS  Google Scholar 

  35. Davis, R. L., Weintraub, H. & Lassar, A. Cell 51, 987–1000 (1987).

    Article  CAS  Google Scholar 

  36. Rhodes, S. J. & Konieczny, S. F. Genes Dev. 3, 2050–2061 (1991).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Molecular Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA

    Paul Hasty & Allan Bradley

  2. Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, 77030, USA

    Allan Bradley

  3. Department of Biochemistry and Molecular Biology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, 77030, USA

    Paul Hasty, Julia H. Morris, Diane G. Edmondson, Judith M. Venuti, Eric N. Olson & William H. Klein

Authors
  1. Paul Hasty
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Allan Bradley
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Julia H. Morris
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Diane G. Edmondson
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Judith M. Venuti
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Eric N. Olson
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. William H. Klein
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hasty, P., Bradley, A., Morris, J. et al. Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature 364, 501–506 (1993). https://doi.org/10.1038/364501a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/364501a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing