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Article
Nature 337, 331 - 337 (26 January 1989); doi:10.1038/337331a0

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

Carol W. Greider* & Elizabeth H. Blackburn

* Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, New York 11724, USA
Department of Molecular Biology, University of California, Berkeley, California 94720, USA

The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.

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