Abstract
Sleep is accompanied by alterations in neurophysiological activity in many discrete regions in the brain1. Such alterations could be expected to be accompanied by corresponding changes in local metabolic rate2. We have now looked for the specific regions involved in sleep, at least in the stages other than rapid eye movement (REM) sleep, by using the [2-14C]deoxyglucose method for measuring local cerebral glucose utilization3 in the rhesus monkey. Contrary to what many have predicted, animals during stages 2–4 of sleep exhibited a non-selective, generalized 30% decrease in cerebral metabolic rate. Of the 75 structures measured, none exhibited a higher rate in non-REM sleep than in wakefulness.
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Kennedy, C., Gillin, J., Mendelson, W. et al. Local cerebral glucose utilization in non-rapid eye movement sleep. Nature 297, 325–327 (1982). https://doi.org/10.1038/297325a0
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DOI: https://doi.org/10.1038/297325a0
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