Abstract
Changes in thymine concentration in the growth medium affect the chromosome replication time of thymineless cells. This alone may account for changes in cell composition and provide a demonstration of the absence of coupling between replication velocity and growth rate.
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References
Cooper, S., and Helmstetter, C. E., J. Mol. Biol., 31, 519 (1968).
Helmstetter, C. E., and Cooper, S., J. Mol. Biol., 31, 507 (1968).
Maaløe, O., Cold Spring Harbor Symp. Quant. Biol., 26, 45 (1961).
Pritchard, R. H., Barth, P. T., and Collins, J., Symp. Soc. Gen. Microbiol., 19, 263 (1969).
Beacham, I., Barth, P. T., and Pritchard, R. H., Biochim. Biophys. Acta., 166, 589 (1968).
Lark, K. G., Bacteriol. Rev., 30, 3 (1966).
Cohen, S. S., and Barner, H. D., Proc. US Nat. Acad. Sci., 40, 885 (1954).
Pritchard, R. H., and Lark, K. G., J. Mol. Biol., 9, 288 (1964).
Friesen, J. D., and Maaløe, O., Biochim. Biophys. Acta., 95, 436 (1965).
Cairns, J., J. Mol. Biol., 6, 208 (1963).
Donachie, W. D., Nature, 219, 1077 (1968).
Helmstetter, C. E., and Pierucci, O., J. Bact., 95, 1627 (1968).
Maaløe, O., and Hanawalt, P. C., J. Mol. Biol., 3, 144 (1961).
Hanawalt, P. C., Maaløe, O., Cummings, D. J., and Schaechter, M., J. Mol. Biol., 3, 156 (1961).
Lark, K. G., Repko, T., and Hoffman, E. J., Biochim. Biophys. Acta., 76, 9 (1963).
Caro, L., and Berg, C. M., J. Mol. Biol., 45, 325 (1969).
Powell, E. O., J. Gen. Microbiol., 15, 492 (1956).
Sueoka, N., and Yoshikawa, H., Genetics, 52, 747 (1965).
Donachie, W. D., J. Bacteriol., 100, 260 (1969).
Maaløe, O., and Rasmussen, K. V., Colloq. Intern. Centre Nat. Rech. Sci., 124, 165 (1963).
Pierucci, O., and Helmstetter, C. E., Fed. Proc., 28, 1755 (1969).
Schaechter, M., Maaløe, O., and Kjeldgaard, N. O., J. Gen. Microbiol., 19, 592 (1958).
Doudney, C. O., Nature, 211, 39 (1966).
Freifelder, D., J. Mol. Biol., 45, 1 (1969).
Pauling, C., and Hamm, L., Proc. US Nat. Acad. Sci., 60, 1495 (1968).
Neuhard, J., Biochim. Biophys. Acta, 129, 104 (1966).
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PRITCHARD, R., ZARITSKY, A. Effect of Thymine Concentration on the Replication Velocity of DNA in a Thymineless Mutant of Escherichia coli. Nature 226, 126–131 (1970). https://doi.org/10.1038/226126a0
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DOI: https://doi.org/10.1038/226126a0
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