Abstract
STUDIES in this laboratory have yielded evidence with both plants and animals that the conversion of D-glucose to L-ascorbic acid is by way of D-glucuronic acid and L-gulonic acid (or derivatives), and it seems that D-galactose may also pass to L-ascorbic acid through corresponding intermediates. The overall conversion of sugars (D-glucose, D-fructose and D-mannose) into L-ascorbic acid had, of course, been demonstrated previously, by Ray1 and others in plants, and by Jackel, Mosbach, Burns and King2 in animals.
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References
Ray, S. N., Biochem. J., 28, 996 (1934).
Jackel, S. S., Mosbach, E. H., Burns, J. J., and King, C. G., J. Biol. Chem., 186, 569 (1950).
Horowitz, H. H., Doerschuk, A. P., and King, C. G., J. Biol. Chem., 199, 193 (1952).
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ISHERWOOD, F., CHEN, Y. & MAPSON, L. Synthesis of L-Ascorbic Acid in Plants and Animals. Nature 171, 348–349 (1953). https://doi.org/10.1038/171348a0
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DOI: https://doi.org/10.1038/171348a0
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