WEB FOCUS
Telomere biology
In this focus
Telomeres, which cap the ends of linear chromosomes, are only a small proportion of the total genome content, but their function is critical. The telomere structure facilitates full replication of the chromosome, and prevents chromosome ends from engaging in fusions. Cell division-dependent shortening of telomeres is associated with ageing, and several human diseases result from telomere dysfunction.
Image: Nadya Dimitrova, Yi-Chun M. Chen, David L. Spector & Titia de Lange
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Current Research
News
Chromosome protection scoops Nobel - Free access
Alison Abbott
Nature 461, 706–707 (8 October 2009) doi:10.1038/461706a
Article
An RNA–dependent RNA polymerase formed by TERT and the RMRP RNA
Yoshiko Maida et al.
Nature 461, 230–235 (10 September 2009) doi:10.1038/nature08283
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Letter
Multiple roles for MRE11 at uncapped telomeres
Yibin Deng, Xiaolan Guo, David O. Ferguson & Sandy Chang
Nature 460, 914–918 (13 August 2009) doi:10.1038/nature08196
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Article
Histone H4 lysine 16 acetylation regulates cellular lifespan
Weiwei Dang et al.
Nature 459, 802–807 (11 June 2009) doi:10.1038/nature08085
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Article
Spliceosomal cleavage generates the 3' end of telomerase RNA
Jessica A. Box, Jeremy T. Bunch, Wen Tang & Peter Baumann
Nature 456, 910–914 (18 December 2008) doi:10.1038/nature07584
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News and Views
Molecular biology: Spliceosome meets telomerase
Sophie Bonnal & Juan Valcárcel
Nature 456, 879–880 (18 December 2008) doi:10.1038/456879a
Letter
53BP1 promotes non–homologous end joining of telomeres by increasing chromatin mobility
Nadya Dimitrova, Yi-Chun M. Chen, David L. Spector & Titia de Lange
Nature 456, 524–528 (27 November 2008) doi:10.1038/nature07433
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Article
Structure of the Tribolium castaneum telomerase catalytic subunit TERT
Andrew J. Gillis, Anthony P. Schuller & Emmanuel Skordalakes
Nature 455, 633–637 (2 October 2008) doi:10.1038/nature07283
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Letter
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Eriko Michishita et al.
Nature 452, 492–496 (27 March 2008) doi:10.1038/nature06736
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Archive
News
Minimum telomere length defined for healthy cells - Free access
Heidi Ledford
Nature 449, 515 (4 October 2007) doi:10.1038/449515a
Letter
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
Eros Lazzerini Denchi & Titia de Lange
Nature 448, 1068–1071 (30 August 2007) doi:10.1038/nature06065
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News and Views
Molecular biology: Damage control
Claus M. Azzalin & Joachim Lingner
Nature 448, 1001–1002 (30 August 2007) doi:10.1038/4481001a
Review Article
The common biology of cancer and ageing
Toren Finkel, Manuel Serrano & Maria A. Blasco
Nature 448, 767–774 (16 August 2007) doi:10.1038/nature05985
Letter
Break-induced replication and telomerase-independent telomere maintenance require Pol32
John R. Lydeard, Suvi Jain, Miyuki Yamaguchi & James E. Haber
Nature 448, 820–823 (16 August 2007) doi:10.1038/nature06047
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Review Article
Replication and protection of telomeres
Ramiro E. Verdun & Jan Karlseder
Nature 447, 924–931 (21 June 2007) doi:10.1038/nature05976
Letter
Endonuclease-independent LINE-1 retrotransposition at mammalian telomeres
Tammy A. Morrish et al.
Nature 446, 208–212 (8 March 2007) doi:10.1038/nature05560
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Article
The POT1-TPP1 telomere complex is a telomerase processivity factor
Feng Wang et al.
Nature 445, 506–510 (1 February 2007) doi:10.1038/nature05454
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Letter
TPP1 is a homologue of ciliate TEBP-β and interacts with POT1 to recruit telomerase
Huawei Xin et al.
Nature 445, 559–562 (1 February 2007) doi:10.1038/nature05469
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Letter
Semi-conservative DNA replication through telomeres requires Taz1
Kyle M. Miller, Ofer Rog and Julia Promisel Cooper
Nature 440, 824–828 (6 April 2006) doi:10.1038/nature04638
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Human subtelomeres are hot spots of interchromosomal recombination and segmental duplication
Elena V. Linardopoulou et al.
Nature 437, 94–100 (1 September 2005) doi:10.1038/nature04029
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Article
The yeast Pif1p helicase removes telomerase from telomeric DNA
Jean-Baptiste Boulé, Leticia R. Vega & Virginia A. Zakian
Nature 438, 57–61 (3 November 2005) doi:10.1038/nature04091
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Letter
Conditional telomerase induction causes proliferation of hair follicle stem cells
Kavita Y. Sarin et al.
Nature 436, 1048–1052 (18 August 2005) doi:10.1038/nature03836
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Letter
DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA
Ming Lei, Elaine R. Podell, Peter Baumann & Thomas R. Cech
Nature 426, 198–203 (13 November 2003) doi:10.1038/nature02092
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Letter
A DNA damage checkpoint response in telomere-initiated senescence
Fabrizio d'Adda di Fagagna et al.
Nature 426, 194–198 (13 November 2003) doi:10.1038/nature02118
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Letter
POT1 as a terminal transducer of TRF1 telomere length control
Diego Loayza & Titia de Lange
Nature 423, 1013–1018 (26 June 2003) doi:10.1038/nature01688
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News and Views
Telomeres: Taking the measure
Vicki Lundblad
Nature 423, 926–927 (26 June 2003) doi:10.1038/423926a
Letter
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
Kwok-Kin Wong et al.
Nature 421, 643–648 (6 February 2003) doi:10.1038/nature01385
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Letter
Crystal structure of parallel quadruplexes from human telomeric DNA
Gary N. Parkinson, Michael P. H. Lee & Stephen Neidle
Nature 417, 876–880 (20 June 2002) doi:10.1038/nature755
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News and Views
Structural biology: A molecular propeller
Dinshaw J. Patel
Nature 417, 807–808 (20 June 2002) doi:10.1038/417807a
Letter
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
Tom Vulliamy et al.
Nature 413, 432–435 (27 September 2001) doi:10.1038/35096585
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Progress
Telomere states and cell fates
Elizabeth H. Blackburn
Nature 408, 53–56 (2 November 2000) doi:10.1038/35040500
Letter
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
Steven E. Artandi et al.
Nature 406, 641–645 (10 August 2000) doi:10.1038/35020592
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Letter
A telomerase component is defective in the human disease dyskeratosis congenita
James R. Mitchell, Emily Wood & Kathleen Collins
Nature 402, 551–555 (2 December 1999) doi:10.1038/990141
Letter
Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle
Anita G. Seto, Arthur J. Zaug, Suzanne G. Sobel, Sandra L. Wolin & Thomas R. Cech
Nature 401, 177–180 (9 September 1999) doi:10.1038/43694
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Letter
Creation of human tumour cells with defined genetic elements
William C. Hahn et al.
Nature 400, 464–468 (29 July 1999) doi:10.1038/22780
Letter
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
Tohru Kiyono et al.
Nature 396, 84–88 (5 November 1998) doi:10.1038/23962
Article
Essential role of mouse telomerase in highly proliferative organs
Han-Woong Lee et al.
Nature 392, 569–574 (9 April 1998) doi:10.1038/33345
Letter
Control of telomere length by the human telomeric protein TRF1
Bas van Steensel & Titia de Lange
Nature 385, 740–743 (20 February 1997) doi:10.1038/385740a0
Letter
Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats
Anat Krauskopf & Elizabeth H. Blackburn
Nature 383, 354–357 (26 September 1996) doi:10.1038/383354a0
Article
Runaway telomere elongation caused by telomerase RNA gene mutations
Michael J. McEachern & Elizabeth H. Blackburn
Nature 376, 403–409 (3 August 1995) doi:10.1038/376403a0
Article
Crystal structure of four-stranded Oxytricha telomeric DNA
ChulHee Kang, Xiaohua Zhang, Robert Ratliff, Robert Moyzis & Alexander Rich
Nature 356, 126–131 (12 March 1992) doi:10.1038/356126a0
Letter
Telomerase primer specificity and chromosome healing
Lea A. Harrington & Carol W. Greider
Nature 353, 451–454 (3 October 1991) doi:10.1038/353451a0
Letter
Hypervariable ultra-long telomeres in mice
David Kipling & Howard J. Cooke
Nature 347, 400–402 (27 September 1990) doi:10.1038/347400a0
Letter
Telomere reduction in human colorectal carcinoma and with ageing
Nicholas D. Hastie et al.
Nature 346, 866–868 (30 August 1990) doi:10.1038/346866a0
Letter
Telomeres shorten during ageing of human fibroblasts
Calvin B. Harley, A. Bruce Futcher & Carol W. Greider
Nature 345, 458–460 (31 May 1990) doi:10.1038/345458a0
Article
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
Guo-Liang Yu, John D. Bradley, Laura D. Attardi & Elizabeth H. Blackburn
Nature 344, 126–132 (8 March 1990) doi:10.1038/344126a0
Letter
Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops
Wesley I. Sundquist & Aaron Klug
Nature 342, 825–829 (14 December 1989) doi:10.1038/342825a0
Scientific Correspondence
Telomere formation in yeast
Virginia A. Zakian & Ann F. Pluta
Nature 338, 468 (6 April 1989) doi:10.1038/338468a0
Article
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
Carol W. Greider & Elizabeth H. Blackburn
Nature 337, 331–337 (26 January 1989) doi:10.1038/408053a0
Letter
Unusual DNA sequences associated with the ends of yeast chromosomes
Richard W. Walmsley, Clarence S. Chan, Bik-Kwoon Tye & Thomas D. Petes
Nature 310, 157–160 (12 July 1984) doi:10.1038/310157a0
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