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  • Nature Outline |

    Widely dubbed ‘the guardian of the genome’, the protein p53 provides important protection against cancer — when it is active, that is.

    Image: Andrew Khrosravini

  • Nature Outline |

    The progressive damage to the retina seen in the most common advanced form of age-related macular degeneration (AMD) cannot currently be slowed, let alone stopped. Researchers are pursuing a wide variety of strategies to change this.

    Image: Rory Waudby-Tolley

  • Nature Outline |

    Some rare heart defects in newborns can be managed by rerouting the circulatory system — and surgeons are working to intervene before a fetus is born.

    Image: Laura N-Tamara

  • Nature Outline |

    Originally treasured as a beautiful, symbolic and expensive gemstone, and later developed as an industrial work-horse, diamond is now entering a new realm of sensing applications that depend on its unique quantum characteristics.

    Image: Rosanna Wan

  • Nature Outline |

    Thousands of species of bacteria, fungi, viruses and archaea live on human skin.

    Image: Andrew Khosravani for Nature

  • Nature Outline |

    People with cancer of the prostate currently have numerous treatment options available to them. But one of the most established, a type of radiation therapy known as brachytherapy, seems to be falling out of favour with clinicians.

    Image: Andrew Khosravani

  • Nature Outline |

    Some of the most effective new pharmaceutical drugs are highly complex biological molecules.

    Image: Andrew Khosravani

  • Nature Outline |

    Long considered to be permanent, the extensive scarring found in livers with cirrhosis is now thought to be reversible.

    Image: Andrew Khosravani

  • Nature Outline |

    Ulcerative colitis is a debilitating and incurable condition. But researchers have found fresh angles of attack, and a host of upcoming treatments raise the prospect of a durable victory against this common form of inflammatory bowel disease.

    Image: Iris Abols

  • Nature Outline |

    Researchers are currently exploring a number of approaches to stimulating spinal-cord regeneration. Should they be successful, the lives of those with a spinal-cord injury will change once again.

    Image: Rosanna Wan

  • Nature Outline |

    Bone fractures that fail to heal with conventional treatment are known as non-union bone fractures. They cause prolonged pain and disability. Work is under way to improve the success rate of surgical repair and to accelerate the bone-healing process.

    Image: Rory Waudby-Tolley