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  • Focus |

    In the world of stem-cell research, attention is increasingly focused on the microenvironments within an organism where stem cells reside - the stem-cell niches. There is now evidence that the molecular signals exchanged between stem cells and other cells within these niches are key factors in stem-cell control. Finding and identifying these signals has become a major thrust in stem-cell research. Produced with support from Abcam

  • Focus |

    Is growing old a good thing? As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. In this web focus, Natureshows that, as previously suggested byin vitrostudies, oncogene-induced cellular senescence represents a safety mechanism to suppress tumour progressionin vivo.

  • Focus |

    No matter what side of the road they're on, chickens are an extremely important model for many fields of biology. Read Nature's extensive resource for the chicken genome with free access to the latest original research, as with all our primary genome content.

  • Focus |

    The first of the chimpanzee's chromosomes has been sequenced. What can this accomplishment tell us about how we have come to look and act so differently from our chimp relatives?

  • Focus |

    The rat, both scourge and servant to mankind, has had its genome sequence completed. Read Nature's free focus, including news, features, interactive graphics and access to a special issue ofGenome Research.

  • Special |

    The South Korean stem-cell researcher Woo Suk Hwang has been at the centre of one of the largest investigations of scientific fraud in living memory. Here Nature collects all our material about the case.

  • Focus |

    The Y chromosome - with the genes to make a man - has been sequenced. Often regarded as a genetic wasteland, the sequence reveals that we may have underestimated its powers.

  • Special |

    To celebrate the end of the year, Naturelooks back on the stories that changed our world, made you visit the site in droves, or simply made us laugh.

  • Insight |

    If laid end to end, the vessels from a typical adult would circle the Earth twice. Little surprise then, that the process of growing new blood vessels - angiogenesis - is a fundamental biological mechanism that can result in serious disease when it goes wrong. More than US$4billion has been invested in the research and development of new drugs to promote or inhibit angiogenesis, making it one of the most heavily funded areas of medical research today. This Nature Insight describes many of the physiological processes and introduces exciting applications that have recently been made available.

  • Focus |

    Ion channels allow the movement of ions across cell membranes, and therefore fundamental physiological processes such as muscle contraction.

  • Insight |

    Biological membranes are more complex than was first thought when the 'fluid mosaic model' was first proposed in 1972. The wealth of new data on membrane protein structures is revolutionising our understanding of membrane architecture and the principles that govern protein folding. From membrane protein biophysics to the cell biology of membrane processes, this NatureInsight introduces the most exciting research in this field.Nature carries sole responsibility for all editorial production.

  • Milestone |

    Milestones in Gene Expression is a collaborative project involving six journals - Nature,Nature Cell Biology,Nature Genetics,Nature Reviews Genetics,Nature Reviews Molecular Cell BiologyandNature Structural & Molecular Biology- and celebrates almost 50 years of discoveries in the field of transcription and chromatin.