Review Articles

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  • Structural studies of amyloid filaments purified from brains of people with neurodegenerative diseases link specific amyloid folds with distinct diseases and provide a basis for the development of models of neurodegenerative disease.

    • Sjors H. W. Scheres
    • Benjamin Ryskeldi-Falcon
    • Michel Goedert
    Review Article
  • This Review provides a perspective on the development of non-cancer therapies based on human genetics studies and suggests measures that can be taken to streamline the pipeline from initial genetic discovery to approved therapy.

    • Katerina Trajanoska
    • Claude Bhérer
    • Vincent Mooser
    Review Article
  • The advances in artificial intelligence over the past decade are examined, with a discussion on how artificial intelligence systems can aid the scientific process and the central issues that remain despite advances.

    • Hanchen Wang
    • Tianfan Fu
    • Marinka Zitnik
    Review Article
  • This Review addresses the current understanding of the roles of tissue-resident macrophages in physiology and disease, including their development and their functions in tissue remodelling and nutrient recycling.

    • Tomi Lazarov
    • Sergio Juarez-Carreño
    • Frederic Geissmann
    Review Article
  • This Review examines the interplay between the nervous system and tumours, from cancer initiation to progression and metastasis.

    • Rebecca Mancusi
    • Michelle Monje
    Review Article
  • This Review examines the palaeobiology of Australopithecus in terms of morphology, phylogeny, diet, tool use, locomotor behaviour and other characteristics, and considers the role of this genus of hominins in human evolution.

    • Zeresenay Alemseged
    Review Article
  • Examination of available evidence on whether anthropogenic global warming was preceded by a long-term warming trend or by global cooling provides support for a relatively mild millennial-scale global thermal maximum during the mid-Holocene.

    • Darrell S. Kaufman
    • Ellie Broadman
    Review Article
  • Recent key developments in the exploration of kagome materials are reviewed, including fundamental concepts of a kagome lattice, realizations of Chern and Weyl topological magnetism, flat-band many-body correlations, and unconventional charge-density waves and superconductivity.

    • Jia-Xin Yin
    • Biao Lian
    • M. Zahid Hasan
    Review Article
  • Anatomical, cellular and molecular immune interactions at the borders of the central nervous system control homeostatic brain function and can lead to neurological or psychiatric diseases, representing potential therapeutic targets.

    • Justin Rustenhoven
    • Jonathan Kipnis
    Review Article
  •  Analysis of the East Antarctic Ice Sheet response to past warm periods and current observations of change highlight the importance of satisfying the Paris Climate Agreement to avoid a multi-metre contribution to sea level over the next few centuries.

    • Chris R. Stokes
    • Nerilie J. Abram
    • Pippa L. Whitehouse
    Review Article
  • The highlights of a wide range of studies using data from the Chandra X-ray Observatory and the X-ray Multi-Mirror Mission (XMM-Newton) are reviewed.

    • Belinda J. Wilkes
    • Wallace Tucker
    • Maria Santos-Lleo
    Review Article
  • Recent progress in computational enzyme design, active site engineering and directed evolution are reviewed, highlighting methodological innovations needed to deliver improved designer biocatalysts.

    • Sarah L. Lovelock
    • Rebecca Crawshaw
    • Anthony P. Green
    Review Article
  • Oceanic plate carbon reservoirs are reconstructed and the fate of subducted carbon is tracked using thermodynamic modelling, challenging previous views and providing boundary conditions for future carbon cycle models.

    • R. Dietmar Müller
    • Ben Mather
    • Sabin Zahirovic
    Review Article
  • Recent theoretical and experimental progress in identifying and understanding magnetic topological materials is reviewed, highlighting the antiferromagnetic topological insulator MnBi2Te4 and the ferromagnetic Weyl semimetal Co3Sn2S2, and future research directions are discussed.

    • B. Andrei Bernevig
    • Claudia Felser
    • Haim Beidenkopf
    Review Article
  • The essential properties of moiré materials and the progress and latest developments in the field are reviewed, and their fabrication and physics are discussed from a reproducibility perspective.

    • Chun Ning Lau
    • Marc W. Bockrath
    • Fan Zhang
    Review Article