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  • The current status and future perspectives for quantum simulation are overviewed, and the potential for practical quantum computational advantage is analysed by comparing classical numerical methods with analogue and digital quantum simulators.

    • Andrew J. Daley
    • Immanuel Bloch
    • Peter Zoller
  • Ten years since the discovery of the Higgs boson, the exploration of the Higgs sector, as this overview shows, has progressed far beyond original expectations, but many research questions still remain open.

    • Gavin P. Salam
    • Lian-Tao Wang
    • Giulia Zanderighi
  • The control of light–matter interactions as a way to manipulate and synthesize strongly correlated quantum matter is discussed, highlighting a field termed ‘strongly correlated electron–photon science’.

    • Jacqueline Bloch
    • Andrea Cavalleri
    • Angel Rubio
  • Standards and recommendations for transitioning organizations to quantum-secure cryptographic protocols are outlined, including a discussion of transition timelines and the leading strategies to protect systems against quantum attacks.

    • David Joseph
    • Rafael Misoczki
    • Royal Hansen
  • A findable, accessible, interoperable and reusable (FAIR) data infrastructure is discussed to turn the large amount of research data generated by the field of materials science into knowledge and value.

    • Matthias Scheffler
    • Martin Aeschlimann
    • Claudia Draxl
  • The benefits and future prospects of neuromorphic, or bio-inspired, computing technologies are discussed, as is the need for a global, coordinated approach to funding, research and collaboration.

    • A. Mehonic
    • A. J. Kenyon
  • The SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme provides a real-time risk assessment of SARS-CoV-2 variants with the potential to affect transmission, virulence and resistance to infection- and vaccine-induced immunity.

    • Marciela M. DeGrace
    • Elodie Ghedin
    • Mehul S. Suthar
  • An assessment of the land-to-ocean cycling of carbon through inland waters, estuaries, tidal wetlands and continental shelf waters provides a perspective on the global carbon cycle and identifies key knowledge gaps.

    • Pierre Regnier
    • Laure Resplandy
    • Philippe Ciais
  • The concept of 'Embodied Energy'—in which the components of a robot or device both store energy and provide a mechanical or structural function—is put forward, along with specific robot-design principles.

    • Cameron A. Aubin
    • Benjamin Gorissen
    • Robert F. Shepherd
  • The Dog Aging Project is an open-data, community science study to identify genetic, environmental and lifestyle factors associated with canine healthy lifespan, generating knowledge that could readily translate to human ageing.

    • Kate E. Creevy
    • Joshua M. Akey
    • Benjamin S. Wilfond
  • The economic, technical, environmental and safety requirements of battery-powered aircraft are considered, and promising technologies and future prospects for battery innovation are discussed.

    • Venkatasubramanian Viswanathan
    • Alan H. Epstein
    • Michael Winter
  • High-temperature, high-acidity and low-oxygen extremes may pose a particular threat to marine ecosystems, requiring a major effort to understand them and the ability of marine life to respond to them.

    • Nicolas Gruber
    • Philip W. Boyd
    • Meike Vogt
  • Computing approaches based on mechanical mechanisms are discussed, with a view towards a framework in which adaptable materials and structures act as a distributed information processing network.

    • Hiromi Yasuda
    • Philip R. Buskohl
    • Jordan R. Raney
  • This Perspective outlines the Human Developmental Cell Atlas initiative, which uses state-of-the-art technologies to map and model human development across gestation, and discusses the early milestones that have been achieved.

    • Muzlifah Haniffa
    • Deanne Taylor
    • Matthias Zilbauer