Letters

  • Letter |

    seqFISH+, an evolution of sequential fluorescence in situ hybridization with super-resolution imaging capabilities, is used to image mRNAs of 10,000 genes in cultured cells and mouse brain slices, demonstrating the ability to generate spatial atlases and to perform discovery-driven studies in situ.

    • Chee-Huat Linus Eng
    • , Michael Lawson
    • , Qian Zhu
    • , Ruben Dries
    • , Noushin Koulena
    • , Yodai Takei
    • , Jina Yun
    • , Christopher Cronin
    • , Christoph Karp
    • , Guo-Cheng Yuan
    •  & Long Cai
  • Letter |

    Future gravitational-wave detectors are expected to be limited by quantum back action, which is now found in the audio band in a low-loss optomechanical system.

    • Jonathan Cripe
    • , Nancy Aggarwal
    • , Robert Lanza
    • , Adam Libson
    • , Robinjeet Singh
    • , Paula Heu
    • , David Follman
    • , Garrett D. Cole
    • , Nergis Mavalvala
    •  & Thomas Corbitt
  • Letter |

    Belief in moralizing gods followed the expansion of human societies and may have been preceded by doctrinal rituals that contributed to the initial rise of social complexity.

    • Harvey Whitehouse
    • , Pieter François
    • , Patrick E. Savage
    • , Thomas E. Currie
    • , Kevin C. Feeney
    • , Enrico Cioni
    • , Rosalind Purcell
    • , Robert M. Ross
    • , Jennifer Larson
    • , John Baines
    • , Barend ter Haar
    • , Alan Covey
    •  & Peter Turchin
  • Letter |

    Angle-resolved photoemission spectroscopy measurements in CoSi reveal the presence of unconventional chiral fermions near the Fermi level, with giant surface Fermi arcs and one pair of well separated chiral nodes.

    • Zhicheng Rao
    • , Hang Li
    • , Tiantian Zhang
    • , Shangjie Tian
    • , Chenghe Li
    • , Binbin Fu
    • , Cenyao Tang
    • , Le Wang
    • , Zhilin Li
    • , Wenhui Fan
    • , Jiajun Li
    • , Yaobo Huang
    • , Zhehong Liu
    • , Youwen Long
    • , Chen Fang
    • , Hongming Weng
    • , Youguo Shi
    • , Hechang Lei
    • , Yujie Sun
    • , Tian Qian
    •  & Hong Ding
  • Letter |

    Crystal structures of a five-protein complex comprising the inner-membrane components of the bacterial lipopolysaccharide transporter provide insight into the mechanism of extraction of lipopolysaccharide from the inner membrane and its transport to the outer membrane.

    • Tristan W. Owens
    • , Rebecca J. Taylor
    • , Karanbir S. Pahil
    • , Blake R. Bertani
    • , Natividad Ruiz
    • , Andrew C. Kruse
    •  & Daniel Kahne
  • Letter |

    A stochastic robotic system shows deterministic behaviour—such as locomotion, object transport and phototaxis—from the collective motion of many loosely coupled disk-shaped ‘particles’ that perform only volumetric oscillations.

    • Shuguang Li
    • , Richa Batra
    • , David Brown
    • , Hyun-Dong Chang
    • , Nikhil Ranganathan
    • , Chuck Hoberman
    • , Daniela Rus
    •  & Hod Lipson
  • Letter |

    Angle-resolved photoemission spectroscopy measurements reveal that CoSi and RhSi are nearly ideal topological conductors, with structural chirality and surface helicoid arcs of topological charge ±2 arising from bulk multifold chiral states.

    • Daniel S. Sanchez
    • , Ilya Belopolski
    • , Tyler A. Cochran
    • , Xitong Xu
    • , Jia-Xin Yin
    • , Guoqing Chang
    • , Weiwei Xie
    • , Kaustuv Manna
    • , Vicky Süß
    • , Cheng-Yi Huang
    • , Nasser Alidoust
    • , Daniel Multer
    • , Songtian S. Zhang
    • , Nana Shumiya
    • , Xirui Wang
    • , Guang-Qiang Wang
    • , Tay-Rong Chang
    • , Claudia Felser
    • , Su-Yang Xu
    • , Shuang Jia
    • , Hsin Lin
    •  & M. Zahid Hasan
  • Letter |

    Huge X-ray structures, termed Galactic Centre ‘chimneys’, extending hundreds of parsecs above and below the Galactic plane, appear to be exhaust channels connecting the Galactic Centre region to the Fermi bubbles.

    • G. Ponti
    • , F. Hofmann
    • , E. Churazov
    • , M. R. Morris
    • , F. Haberl
    • , K. Nandra
    • , R. Terrier
    • , M. Clavel
    •  & A. Goldwurm
  • Letter |

    An inversion model for the ultraslow-spreading Mohns Ridge, combining controlled source electromagnetic and magnetotelluric data, reveals passive mantle upwelling controlled by slow and asymmetric plate movements.

    • Ståle Emil Johansen
    • , Martin Panzner
    • , Rune Mittet
    • , Hans E. F. Amundsen
    • , Anna Lim
    • , Eirik Vik
    • , Martin Landrø
    •  & Børge Arntsen
  • Letter |

    In human neuroblastoma tumours, MYCN is engaged in a USP11–BRCA1-dependent manner to suppress the accumulation of stalled RNAPII and induces both the activation and repression of genes.

    • Steffi Herold
    • , Jacqueline Kalb
    • , Gabriele Büchel
    • , Carsten P. Ade
    • , Apoorva Baluapuri
    • , Jiajia Xu
    • , Jan Koster
    • , Daniel Solvie
    • , Anne Carstensen
    • , Christina Klotz
    • , Sabrina Rodewald
    • , Christina Schülein-Völk
    • , Matthias Dobbelstein
    • , Elmar Wolf
    • , Jan Molenaar
    • , Rogier Versteeg
    • , Susanne Walz
    •  & Martin Eilers
  • Letter |

    Cryo-electron microscopy structures of tau filaments from the brains of three individuals with chronic traumatic encephalopathy reveal distinct assembled tau conformers, with a novel protofilament fold enclosing hydrophobic molecules.

    • Benjamin Falcon
    • , Jasenko Zivanov
    • , Wenjuan Zhang
    • , Alexey G. Murzin
    • , Holly J. Garringer
    • , Ruben Vidal
    • , R. Anthony Crowther
    • , Kathy L. Newell
    • , Bernardino Ghetti
    • , Michel Goedert
    •  & Sjors H. W. Scheres
  • Letter |

    A set of 355 self-assembling DNA ‘tiles’ can be reprogrammed to implement many different computer algorithms—including sorting, palindrome testing and divisibility by three—suggesting that molecular self-assembly could be a reliable algorithmic component in programmable chemical systems.

    • Damien Woods
    • , David Doty
    • , Cameron Myhrvold
    • , Joy Hui
    • , Felix Zhou
    • , Peng Yin
    •  & Erik Winfree
  • Letter |

    Observations of asteroid (101955) Bennu with NASA’s OSIRIS-REx spacecraft reveal an unexpected surficial diversity that poses a challenge to the success of the sample-return mission.

    • D. S. Lauretta
    • , D. N. DellaGiustina
    • , C. A. Bennett
    • , D. R. Golish
    • , K. J. Becker
    • , S. S. Balram-Knutson
    • , O. S. Barnouin
    • , T. L. Becker
    • , W. F. Bottke
    • , W. V. Boynton
    • , H. Campins
    • , B. E. Clark
    • , H. C. Connolly Jr
    • , C. Y. Drouet d’Aubigny
    • , J. P. Dworkin
    • , J. P. Emery
    • , H. L. Enos
    • , V. E. Hamilton
    • , C. W. Hergenrother
    • , E. S. Howell
    • , M. R. M. Izawa
    • , H. H. Kaplan
    • , M. C. Nolan
    • , B. Rizk
    • , H. L. Roper
    • , D. J. Scheeres
    • , P. H. Smith
    • , K. J. Walsh
    • , C. W. V. Wolner
    • , D. E. Highsmith
    • , J. Small
    • , D. Vokrouhlický
    • , N. E. Bowles
    • , E. Brown
    • , K. L. Donaldson Hanna
    • , T. Warren
    • , C. Brunet
    • , R. A. Chicoine
    • , S. Desjardins
    • , D. Gaudreau
    • , T. Haltigin
    • , S. Millington-Veloza
    • , A. Rubi
    • , J. Aponte
    • , N. Gorius
    • , A. Lunsford
    • , B. Allen
    • , J. Grindlay
    • , D. Guevel
    • , D. Hoak
    • , J. Hong
    • , D. L. Schrader
    • , J. Bayron
    • , O. Golubov
    • , P. Sánchez
    • , J. Stromberg
    • , M. Hirabayashi
    • , C. M. Hartzell
    • , S. Oliver
    • , M. Rascon
    • , A. Harch
    • , J. Joseph
    • , S. Squyres
    • , D. Richardson
    • , J. P. Emery
    • , L. McGraw
    • , R. Ghent
    • , R. P. Binzel
    • , M. M. Al Asad
    • , C. L. Johnson
    • , L. Philpott
    • , H. C. M. Susorney
    • , E. A. Cloutis
    • , R. D. Hanna
    • , H. C. Connolly Jr.
    • , F. Ciceri
    • , A. R. Hildebrand
    • , E.-M. Ibrahim
    • , L. Breitenfeld
    • , T. Glotch
    • , A. D. Rogers
    • , B. E. Clark
    • , S. Ferrone
    • , C. A. Thomas
    • , H. Campins
    • , Y. Fernandez
    • , W. Chang
    • , A. Cheuvront
    • , D. Trang
    • , S. Tachibana
    • , H. Yurimoto
    • , J. R. Brucato
    • , G. Poggiali
    • , M. Pajola
    • , E. Dotto
    • , E. Mazzotta Epifani
    • , M. K. Crombie
    • , C. Lantz
    • , M. R. M. Izawa
    • , J. de Leon
    • , J. Licandro
    • , J. L. Rizos Garcia
    • , S. Clemett
    • , K. Thomas-Keprta
    • , S. Van wal
    • , M. Yoshikawa
    • , J. Bellerose
    • , S. Bhaskaran
    • , C. Boyles
    • , S. R. Chesley
    • , C. M. Elder
    • , D. Farnocchia
    • , A. Harbison
    • , B. Kennedy
    • , A. Knight
    • , N. Martinez-Vlasoff
    • , N. Mastrodemos
    • , T. McElrath
    • , W. Owen
    • , R. Park
    • , B. Rush
    • , L. Swanson
    • , Y. Takahashi
    • , D. Velez
    • , K. Yetter
    • , C. Thayer
    • , C. Adam
    • , P. Antreasian
    • , J. Bauman
    • , C. Bryan
    • , B. Carcich
    • , M. Corvin
    • , J. Geeraert
    • , J. Hoffman
    • , J. M. Leonard
    • , E. Lessac-Chenen
    • , A. Levine
    • , J. McAdams
    • , L. McCarthy
    • , D. Nelson
    • , B. Page
    • , J. Pelgrift
    • , E. Sahr
    • , K. Stakkestad
    • , D. Stanbridge
    • , D. Wibben
    • , B. Williams
    • , K. Williams
    • , P. Wolff
    • , P. Hayne
    • , D. Kubitschek
    • , M. A. Barucci
    • , J. D. P. Deshapriya
    • , S. Fornasier
    • , M. Fulchignoni
    • , P. Hasselmann
    • , F. Merlin
    • , A. Praet
    • , E. B. Bierhaus
    • , O. Billett
    • , A. Boggs
    • , B. Buck
    • , S. Carlson-Kelly
    • , J. Cerna
    • , K. Chaffin
    • , E. Church
    • , M. Coltrin
    • , J. Daly
    • , A. Deguzman
    • , R. Dubisher
    • , D. Eckart
    • , D. Ellis
    • , P. Falkenstern
    • , A. Fisher
    • , M. E. Fisher
    • , P. Fleming
    • , K. Fortney
    • , S. Francis
    • , S. Freund
    • , S. Gonzales
    • , P. Haas
    • , A. Hasten
    • , D. Hauf
    • , A. Hilbert
    • , D. Howell
    • , F. Jaen
    • , N. Jayakody
    • , M. Jenkins
    • , K. Johnson
    • , M. Lefevre
    • , H. Ma
    • , C. Mario
    • , K. Martin
    • , C. May
    • , M. McGee
    • , B. Miller
    • , C. Miller
    • , G. Miller
    • , A. Mirfakhrai
    • , E. Muhle
    • , C. Norman
    • , R. Olds
    • , C. Parish
    • , M. Ryle
    • , M. Schmitzer
    • , P. Sherman
    • , M. Skeen
    • , M. Susak
    • , B. Sutter
    • , Q. Tran
    • , C. Welch
    • , R. Witherspoon
    • , J. Wood
    • , J. Zareski
    • , M. Arvizu-Jakubicki
    • , E. Asphaug
    • , E. Audi
    • , R.-L. Ballouz
    • , R. Bandrowski
    • , K. J. Becker
    • , T. L. Becker
    • , S. Bendall
    • , C. A. Bennett
    • , H. Bloomenthal
    • , D. Blum
    • , W. V. Boynton
    • , J. Brodbeck
    • , K. N. Burke
    • , M. Chojnacki
    • , A. Colpo
    • , J. Contreras
    • , J. Cutts
    • , C. Y. Drouet d’Aubigny
    • , D. Dean
    • , D. N. DellaGiustina
    • , B. Diallo
    • , D. Drinnon
    • , K. Drozd
    • , H. L. Enos
    • , R. Enos
    • , C. Fellows
    • , T. Ferro
    • , M. R. Fisher
    • , G. Fitzgibbon
    • , M. Fitzgibbon
    • , J. Forelli
    • , T. Forrester
    • , I. Galinsky
    • , R. Garcia
    • , A. Gardner
    • , D. R. Golish
    • , N. Habib
    • , D. Hamara
    • , D. Hammond
    • , K. Hanley
    • , K. Harshman
    • , C. W. Hergenrother
    • , K. Herzog
    • , D. Hill
    • , C. Hoekenga
    • , S. Hooven
    • , E. S. Howell
    • , E. Huettner
    • , A. Janakus
    • , J. Jones
    • , T. R. Kareta
    • , J. Kidd
    • , K. Kingsbury
    • , S. S. Balram-Knutson
    • , L. Koelbel
    • , J. Kreiner
    • , D. Lambert
    • , D. S. Lauretta
    • , C. Lewin
    • , B. Lovelace
    • , M. Loveridge
    • , M. Lujan
    • , C. K. Maleszewski
    • , R. Malhotra
    • , K. Marchese
    • , E. McDonough
    • , N. Mogk
    • , V. Morrison
    • , E. Morton
    • , R. Munoz
    • , J. Nelson
    • , M. C. Nolan
    • , J. Padilla
    • , R. Pennington
    • , A. Polit
    • , N. Ramos
    • , V. Reddy
    • , M. Riehl
    • , B. Rizk
    • , H. L. Roper
    • , S. Salazar
    • , S. R. Schwartz
    • , S. Selznick
    • , N. Shultz
    • , P. H. Smith
    • , S. Stewart
    • , S. Sutton
    • , T. Swindle
    • , Y. H. Tang
    • , M. Westermann
    • , C. W. V. Wolner
    • , D. Worden
    • , T. Zega
    • , Z. Zeszut
    • , A. Bjurstrom
    • , L. Bloomquist
    • , C. Dickinson
    • , E. Keates
    • , J. Liang
    • , V. Nifo
    • , A. Taylor
    • , F. Teti
    • , M. Caplinger
    • , H. Bowles
    • , S. Carter
    • , S. Dickenshied
    • , D. Doerres
    • , T. Fisher
    • , W. Hagee
    • , J. Hill
    • , M. Miner
    • , D. Noss
    • , N. Piacentine
    • , M. Smith
    • , A. Toland
    • , P. Wren
    • , M. Bernacki
    • , D. Pino Munoz
    • , S.-i. Watanabe
    • , S. A. Sandford
    • , A. Aqueche
    • , B. Ashman
    • , M. Barker
    • , A. Bartels
    • , K. Berry
    • , B. Bos
    • , R. Burns
    • , A. Calloway
    • , R. Carpenter
    • , N. Castro
    • , R. Cosentino
    • , J. Donaldson
    • , J. P. Dworkin
    • , J. Elsila Cook
    • , C. Emr
    • , D. Everett
    • , D. Fennell
    • , K. Fleshman
    • , D. Folta
    • , D. Gallagher
    • , J. Garvin
    • , K. Getzandanner
    • , D. Glavin
    • , S. Hull
    • , K. Hyde
    • , H. Ido
    • , A. Ingegneri
    • , N. Jones
    • , P. Kaotira
    • , L. F. Lim
    • , A. Liounis
    • , C. Lorentson
    • , D. Lorenz
    • , J. Lyzhoft
    • , E. M. Mazarico
    • , R. Mink
    • , W. Moore
    • , M. Moreau
    • , S. Mullen
    • , J. Nagy
    • , G. Neumann
    • , J. Nuth
    • , D. Poland
    • , D. C. Reuter
    • , L. Rhoads
    • , S. Rieger
    • , D. Rowlands
    • , D. Sallitt
    • , A. Scroggins
    • , G. Shaw
    • , A. A. Simon
    • , J. Swenson
    • , P. Vasudeva
    • , M. Wasser
    • , R. Zellar
    • , J. Grossman
    • , G. Johnston
    • , M. Morris
    • , J. Wendel
    • , A. Burton
    • , L. P. Keller
    • , L. McNamara
    • , S. Messenger
    • , K. Nakamura-Messenger
    • , A. Nguyen
    • , K. Righter
    • , E. Queen
    • , K. Bellamy
    • , K. Dill
    • , S. Gardner
    • , M. Giuntini
    • , B. Key
    • , J. Kissell
    • , D. Patterson
    • , D. Vaughan
    • , B. Wright
    • , R. W. Gaskell
    • , L. Le Corre
    • , J.-Y. Li
    • , J. L. Molaro
    • , E. E. Palmer
    • , M. A. Siegler
    • , P. Tricarico
    • , J. R. Weirich
    • , X.-D. Zou
    • , T. Ireland
    • , K. Tait
    • , P. Bland
    • , S. Anwar
    • , N. Bojorquez-Murphy
    • , P. R. Christensen
    • , C. W. Haberle
    • , G. Mehall
    • , K. Rios
    • , I. Franchi
    • , B. Rozitis
    • , C. B. Beddingfield
    • , J. Marshall
    • , D. N. Brack
    • , A. S. French
    • , J. W. McMahon
    • , D. J. Scheeres
    • , E. R. Jawin
    • , T. J. McCoy
    • , S. Russell
    • , M. Killgore
    • , W. F. Bottke
    • , V. E. Hamilton
    • , H. H. Kaplan
    • , K. J. Walsh
    • , J. L. Bandfield
    • , B. C. Clark
    • , M. Chodas
    • , M. Lambert
    • , R. A. Masterson
    • , M. G. Daly
    • , J. Freemantle
    • , J. A. Seabrook
    • , O. S. Barnouin
    • , K. Craft
    • , R. T. Daly
    • , C. Ernst
    • , R. C. Espiritu
    • , M. Holdridge
    • , M. Jones
    • , A. H. Nair
    • , L. Nguyen
    • , J. Peachey
    • , M. E. Perry
    • , J. Plescia
    • , J. H. Roberts
    • , R. Steele
    • , R. Turner
    • , J. Backer
    • , K. Edmundson
    • , J. Mapel
    • , M. Milazzo
    • , S. Sides
    • , C. Manzoni
    • , B. May
    • , M. Delbo’
    • , G. Libourel
    • , P. Michel
    • , A. Ryan
    • , F. Thuillet
    •  & B. Marty
  • Letter |

    Simulation and measurement of the photoionization of atomic hydrogen at attosecond resolution confirm that the tunnelling of the ejected electron is instantaneous.

    • U. Satya Sainadh
    • , Han Xu
    • , Xiaoshan Wang
    • , A. Atia-Tul-Noor
    • , William C. Wallace
    • , Nicolas Douguet
    • , Alexander Bray
    • , Igor Ivanov
    • , Klaus Bartschat
    • , Anatoli Kheifets
    • , R. T. Sang
    •  & I. V. Litvinyuk
  • Letter |

    Cryo-EM structures of yeast Snf2 bound to the nucleosome in the presence of ADP or an ATP analogue reveal that Snf2 binding leads to distortion of the DNA, and a two-step mechanism underlying chromatin remodelling by Snf2 is proposed.

    • Meijing Li
    • , Xian Xia
    • , Yuanyuan Tian
    • , Qi Jia
    • , Xiaoyu Liu
    • , Ying Lu
    • , Ming Li
    • , Xueming Li
    •  & Zhucheng Chen
  • Letter |

    Microbial generation of a terminal-alkyne-containing amino acid can be encoded into E. coli and provides the potential for in vivo generation of proteins and natural products for click chemistry.

    • J. A. Marchand
    • , M. E. Neugebauer
    • , M. C. Ing
    • , C.-I. Lin
    • , J. G. Pelton
    •  & M. C. Y. Chang
  • Letter |

    A new calibration of the surface brightness–colour relation of eclipsing binary stars gives a distance to the Large Magellanic Cloud that is precise to one per cent.

    • G. Pietrzyński
    • , D. Graczyk
    • , A. Gallenne
    • , W. Gieren
    • , I. B. Thompson
    • , B. Pilecki
    • , P. Karczmarek
    • , M. Górski
    • , K. Suchomska
    • , M. Taormina
    • , B. Zgirski
    • , P. Wielgórski
    • , Z. Kołaczkowski
    • , P. Konorski
    • , S. Villanova
    • , N. Nardetto
    • , P. Kervella
    • , F. Bresolin
    • , R. P. Kudritzki
    • , J. Storm
    • , R. Smolec
    •  & W. Narloch
  • Letter |

    In serotonin-rich tissues, tissue transglutaminase 2 is able to attach serotonin to a glutamine residue in histone H3; this modification mediates permissive gene expression in these tissues.

    • Lorna A. Farrelly
    • , Robert E. Thompson
    • , Shuai Zhao
    • , Ashley E. Lepack
    • , Yang Lyu
    • , Natarajan V. Bhanu
    • , Baichao Zhang
    • , Yong-Hwee E. Loh
    • , Aarthi Ramakrishnan
    • , Krishna C. Vadodaria
    • , Kelly J. Heard
    • , Galina Erikson
    • , Tomoyoshi Nakadai
    • , Ryan M. Bastle
    • , Bradley J. Lukasak
    • , Henry Zebroski III
    • , Natalia Alenina
    • , Michael Bader
    • , Olivier Berton
    • , Robert G. Roeder
    • , Henrik Molina
    • , Fred H. Gage
    • , Li Shen
    • , Benjamin A. Garcia
    • , Haitao Li
    • , Tom W. Muir
    •  & Ian Maze
  • Letter |

    Agreement between two single-ion clocks is demonstrated experimentally at the 10−18 level over a six-month period, confirming a key postulate of Einstein’s theory of relativity with hundredfold-improved precision.

    • Christian Sanner
    • , Nils Huntemann
    • , Richard Lange
    • , Christian Tamm
    • , Ekkehard Peik
    • , Marianna S. Safronova
    •  & Sergey G. Porsev
  • Letter |

    Enzymatic catalysis of pericyclic [6+4] cycloaddition reactions to form ten-membered rings is observed during biosynthesis of the macrocyclic antibiotic streptoseomycin, and the mechanism of these transformations is established.

    • Bo Zhang
    • , Kai Biao Wang
    • , Wen Wang
    • , Xin Wang
    • , Fang Liu
    • , Jiapeng Zhu
    • , Jing Shi
    • , Ling Yu Li
    • , Hao Han
    • , Kuang Xu
    • , Hong Yun Qiao
    • , Xiao Zhang
    • , Rui Hua Jiao
    • , Kendall N. Houk
    • , Yong Liang
    • , Ren Xiang Tan
    •  & Hui Ming Ge
  • Letter |

    Even in the absence of external perturbations, waterfalls can gradually form from planar bedrock riverbeds as a result of unstable interactions between flow hydraulics, sediment transport and bedrock erosion.

    • Joel S. Scheingross
    • , Michael P. Lamb
    •  & Brian M. Fuller
  • Letter |

    A highly site-selective aromatic C–H functionalization reaction that does not require a particular directing group or arene substitution pattern provides functionalized arenes that can participate in various transformations.

    • Florian Berger
    • , Matthew B. Plutschack
    • , Julian Riegger
    • , Wanwan Yu
    • , Samira Speicher
    • , Matthew Ho
    • , Nils Frank
    •  & Tobias Ritter
  • Letter |

    Amphotericin B forms nonselective transmembrane ion channels, and restores host defences of cystic fibrosis airway epithelia independently of the regulatory function of cystic fibrosis transmembrane conductance.

    • Katrina A. Muraglia
    • , Rajeev S. Chorghade
    • , Bo Ram Kim
    • , Xiao Xiao Tang
    • , Viral S. Shah
    • , Anthony S. Grillo
    • , Page N. Daniels
    • , Alexander G. Cioffi
    • , Philip H. Karp
    • , Lingyang Zhu
    • , Michael J. Welsh
    •  & Martin D. Burke
  • Letter |

    A proof-of-concept clinical trial of patients with histiocytoses with MAPK-pathway mutations showed durable responses to treatment with the MEK1 and MEK2 inhibitor cobimetinib, which indicates that histiocytic neoplasms are dependent on MAPK signalling.

    • Eli L. Diamond
    • , Benjamin H. Durham
    • , Gary A. Ulaner
    • , Esther Drill
    • , Justin Buthorn
    • , Michelle Ki
    • , Lillian Bitner
    • , Hana Cho
    • , Robert J. Young
    • , Jasmine H. Francis
    • , Raajit Rampal
    • , Mario Lacouture
    • , Lynn A. Brody
    • , Neval Ozkaya
    • , Ahmet Dogan
    • , Neal Rosen
    • , Alexia Iasonos
    • , Omar Abdel-Wahab
    •  & David M. Hyman
  • Letter |

    Two classification algorithms that use the quantum state space to produce feature maps are demonstrated on a superconducting processor, enabling the solution of problems when the feature space is large and the kernel functions are computationally expensive to estimate.

    • Vojtěch Havlíček
    • , Antonio D. Córcoles
    • , Kristan Temme
    • , Aram W. Harrow
    • , Abhinav Kandala
    • , Jerry M. Chow
    •  & Jay M. Gambetta
  • Letter |

    METTL14 recognizes the trimethyl mark on lysine 36 of histone H3 that directs m6A modifications co-transcriptionally.

    • Huilin Huang
    • , Hengyou Weng
    • , Keren Zhou
    • , Tong Wu
    • , Boxuan Simen Zhao
    • , Mingli Sun
    • , Zhenhua Chen
    • , Xiaolan Deng
    • , Gang Xiao
    • , Franziska Auer
    • , Lars Klemm
    • , Huizhe Wu
    • , Zhixiang Zuo
    • , Xi Qin
    • , Yunzhu Dong
    • , Yile Zhou
    • , Hanjun Qin
    • , Shu Tao
    • , Juan Du
    • , Jun Liu
    • , Zhike Lu
    • , Hang Yin
    • , Ana Mesquita
    • , Celvie L. Yuan
    • , Yueh-Chiang Hu
    • , Wenju Sun
    • , Rui Su
    • , Lei Dong
    • , Chao Shen
    • , Chenying Li
    • , Ying Qing
    • , Xi Jiang
    • , Xiwei Wu
    • , Miao Sun
    • , Jun-Lin Guan
    • , Lianghu Qu
    • , Minjie Wei
    • , Markus Müschen
    • , Gang Huang
    • , Chuan He
    • , Jianhua Yang
    •  & Jianjun Chen
  • Letter |

    In patient-derived xenograft models of breast cancer in mice, an increase in stress hormones during progression or treatment with their synthetic derivatives activates the glucocorticoid receptor, and results in increased metastatic colonization and reduced survival.

    • Milan M. S. Obradović
    • , Baptiste Hamelin
    • , Nenad Manevski
    • , Joana Pinto Couto
    • , Atul Sethi
    • , Marie-May Coissieux
    • , Simone Münst
    • , Ryoko Okamoto
    • , Hubertus Kohler
    • , Alexander Schmidt
    •  & Mohamed Bentires-Alj
  • Letter |

    A statistical framework for breast-cancer recurrence uses long-term follow-up data and a knowledge of molecular subcategories to model distinct disease stages and to predict the risk of relapse.

    • Oscar M. Rueda
    • , Stephen-John Sammut
    • , Jose A. Seoane
    • , Suet-Feung Chin
    • , Jennifer L. Caswell-Jin
    • , Maurizio Callari
    • , Rajbir Batra
    • , Bernard Pereira
    • , Alejandra Bruna
    • , H. Raza Ali
    • , Elena Provenzano
    • , Bin Liu
    • , Michelle Parisien
    • , Cheryl Gillett
    • , Steven McKinney
    • , Andrew R. Green
    • , Leigh Murphy
    • , Arnie Purushotham
    • , Ian O. Ellis
    • , Paul D. Pharoah
    • , Cristina Rueda
    • , Samuel Aparicio
    • , Carlos Caldas
    •  & Christina Curtis
  • Letter |

    Using a thin-film lithium niobate photonic platform, an electro-optic frequency comb generator is realized that is capable of producing wide and stable spectra, spanning more frequencies than the entire telecommunications L-band.

    • Mian Zhang
    • , Brandon Buscaino
    • , Cheng Wang
    • , Amirhassan Shams-Ansari
    • , Christian Reimer
    • , Rongrong Zhu
    • , Joseph M. Kahn
    •  & Marko Lončar
  • Letter |

    Pancreatic cancer activates IL-6–STAT3 signalling in hepatocytes to induce the formation of a pro-metastatic niche in the liver.

    • Jae W. Lee
    • , Meredith L. Stone
    • , Paige M. Porrett
    • , Stacy K. Thomas
    • , Chad A. Komar
    • , Joey H. Li
    • , Devora Delman
    • , Kathleen Graham
    • , Whitney L. Gladney
    • , Xia Hua
    • , Taylor A. Black
    • , Austin L. Chien
    • , Krishna S. Majmundar
    • , Jeffrey C. Thompson
    • , Stephanie S. Yee
    • , Mark H. O’Hara
    • , Charu Aggarwal
    • , Dong Xin
    • , Abraham Shaked
    • , Mingming Gao
    • , Dexi Liu
    • , Mitesh J. Borad
    • , Ramesh K. Ramanathan
    • , Erica L. Carpenter
    • , Ailing Ji
    • , Maria C. de Beer
    • , Frederick C. de Beer
    • , Nancy R. Webb
    •  & Gregory L. Beatty
  • Letter |

    The E3 ubiquitin ligase TRAIP governs the choice between the NEIL3 or the Fanconi anaemia pathway for the repair of DNA interstrand crosslinks.

    • R. Alex Wu
    • , Daniel R. Semlow
    • , Ashley N. Kamimae-Lanning
    • , Olga V. Kochenova
    • , Gheorghe Chistol
    • , Michael R. Hodskinson
    • , Ravindra Amunugama
    • , Justin L. Sparks
    • , Meng Wang
    • , Lin Deng
    • , Claudia A. Mimoso
    • , Emily Low
    • , Ketan J. Patel
    •  & Johannes C. Walter
  • Letter |

    The cryo-electron microscopy structure of human TBK1 in complex with cyclic GMP–AMP-bound chicken STING reveals a binding mode that suggests that STING phosphorylation by TBK1 requires oligomerization of both proteins.

    • Conggang Zhang
    • , Guijun Shang
    • , Xiang Gui
    • , Xuewu Zhang
    • , Xiao-chen Bai
    •  & Zhijian J. Chen
  • Letter |

    Wetlands exposed to rapid sea-level rise over the late Holocene contain more soil carbon than those that experienced a long period of sea-level stability.

    • Kerrylee Rogers
    • , Jeffrey J. Kelleway
    • , Neil Saintilan
    • , J. Patrick Megonigal
    • , Janine B. Adams
    • , James R. Holmquist
    • , Meng Lu
    • , Lisa Schile-Beers
    • , Atun Zawadzki
    • , Debashish Mazumder
    •  & Colin D. Woodroffe
  • Letter |

    The transcription factor BACH1, which targets mitochondrial metabolism, is expressed at high levels in several types of cancer; reducing its expression in tumours makes them more susceptible to treatment with mitochondrial inhibitors.

    • Jiyoung Lee
    • , Ali E. Yesilkanal
    • , Joseph P. Wynne
    • , Casey Frankenberger
    • , Juan Liu
    • , Jielin Yan
    • , Mohamad Elbaz
    • , Daniel C. Rabe
    • , Felicia D. Rustandy
    • , Payal Tiwari
    • , Elizabeth A. Grossman
    • , Peter C. Hart
    • , Christie Kang
    • , Sydney M. Sanderson
    • , Jorge Andrade
    • , Daniel K. Nomura
    • , Marcelo G. Bonini
    • , Jason W. Locasale
    •  & Marsha Rich Rosner
  • Letter |

    Pressure-driven transport of aqueous salts through ångström-scale channels created from two-dimensional materials shows a transistor-like effect in which applying a tiny bias voltage can increase transport by up to 20 times.

    • T. Mouterde
    • , A. Keerthi
    • , A. R. Poggioli
    • , S. A. Dar
    • , A. Siria
    • , A. K. Geim
    • , L. Bocquet
    •  & B. Radha
  • Letter |

    Cryo-electron microscopy structures of full-length STING show that cyclic GMP–AMP induces a half-turn rotation of the ligand-binding domain relative to the transmembrane domain, forming a tetramer and higher-order oligomers for signalling.

    • Guijun Shang
    • , Conggang Zhang
    • , Zhijian J. Chen
    • , Xiao-chen Bai
    •  & Xuewu Zhang
  • Letter |

    Excitonic bands in MoSe2/WS2 heterostructures can hybridize, resulting in a resonant enhancement of moiré superlattice effects.

    • Evgeny M. Alexeev
    • , David A. Ruiz-Tijerina
    • , Mark Danovich
    • , Matthew J. Hamer
    • , Daniel J. Terry
    • , Pramoda K. Nayak
    • , Seongjoon Ahn
    • , Sangyeon Pak
    • , Juwon Lee
    • , Jung Inn Sohn
    • , Maciej R. Molas
    • , Maciej Koperski
    • , Kenji Watanabe
    • , Takashi Taniguchi
    • , Kostya S. Novoselov
    • , Roman V. Gorbachev
    • , Hyeon Suk Shin
    • , Vladimir I. Fal’ko
    •  & Alexander I. Tartakovskii
  • Letter |

    A quantum circuit in an ion-trap quantum computer provides a positive test for the scrambling features of a given unitary process.

    • K. A. Landsman
    • , C. Figgatt
    • , T. Schuster
    • , N. M. Linke
    • , B. Yoshida
    • , N. Y. Yao
    •  & C. Monroe
  • Letter |

    An adult infected with HIV-1 who underwent allogeneic haematopoietic stem-cell transplantation for Hodgkin’s lymphoma using cells from a CCR5Δ32/Δ32 donor achieved full remission of HIV-1 for 18 months after transplantation and 16 months after cessation of antiretroviral therapy.

    • Ravindra K. Gupta
    • , Sultan Abdul-Jawad
    • , Laura E. McCoy
    • , Hoi Ping Mok
    • , Dimitra Peppa
    • , Maria Salgado
    • , Javier Martinez-Picado
    • , Monique Nijhuis
    • , Annemarie M. J. Wensing
    • , Helen Lee
    • , Paul Grant
    • , Eleni Nastouli
    • , Jonathan Lambert
    • , Matthew Pace
    • , Fanny Salasc
    • , Christopher Monit
    • , Andrew J. Innes
    • , Luke Muir
    • , Laura Waters
    • , John Frater
    • , Andrew M. L. Lever
    • , Simon G. Edwards
    • , Ian H. Gabriel
    •  & Eduardo Olavarria
  • Letter |

    Coherent perfect absorption in a disordered medium is demonstrated experimentally in the microwave regime through the realization of a random anti-laser that absorbs engineered radiation with near-perfect efficiency.

    • Kevin Pichler
    • , Matthias Kühmayer
    • , Julian Böhm
    • , Andre Brandstötter
    • , Philipp Ambichl
    • , Ulrich Kuhl
    •  & Stefan Rotter
  • Letter |

    Estimates of spatial patterns of nitrogen discharge into water bodies across China between 1955 and 2014 show that current discharge rates are almost three times the acceptable threshold, and ways to restore a clean water environment are suggested.

    • ChaoQing Yu
    • , Xiao Huang
    • , Han Chen
    • , H. Charles J. Godfray
    • , Jonathon S. Wright
    • , Jim W. Hall
    • , Peng Gong
    • , ShaoQiang Ni
    • , ShengChao Qiao
    • , GuoRui Huang
    • , YuChen Xiao
    • , Jie Zhang
    • , Zhao Feng
    • , XiaoTang Ju
    • , Philippe Ciais
    • , Nils Chr. Stenseth
    • , Dag O. Hessen
    • , ZhanLi Sun
    • , Le Yu
    • , WenJia Cai
    • , HaoHuan Fu
    • , XiaoMeng Huang
    • , Chi Zhang
    • , HongBin Liu
    •  & James Taylor
  • Letter |

    A subtype of early-stage hepatocellular carcinoma characterized by disrupted cholesterol homeostasis and associated with a poor prognosis responds to treatment with the SOAT1 inhibitor avasimibe in a patient-derived xenograft mouse model.

    • Ying Jiang
    • , Aihua Sun
    • , Yang Zhao
    • , Wantao Ying
    • , Huichuan Sun
    • , Xinrong Yang
    • , Baocai Xing
    • , Wei Sun
    • , Liangliang Ren
    • , Bo Hu
    • , Chaoying Li
    • , Li Zhang
    • , Guangrong Qin
    • , Menghuan Zhang
    • , Ning Chen
    • , Manli Zhang
    • , Yin Huang
    • , Jinan Zhou
    • , Yan Zhao
    • , Mingwei Liu
    • , Xiaodong Zhu
    • , Yang Qiu
    • , Yanjun Sun
    • , Cheng Huang
    • , Meng Yan
    • , Mingchao Wang
    • , Wei Liu
    • , Fang Tian
    • , Huali Xu
    • , Jian Zhou
    • , Zhenyu Wu
    • , Tieliu Shi
    • , Weimin Zhu
    • , Jun Qin
    • , Lu Xie
    • , Jia Fan
    • , Xiaohong Qian
    • , Fuchu He
    • , Fuchu He
    • , Xiaohong Qian
    • , Jun Qin
    • , Ying Jiang
    • , Wantao Ying
    • , Wei Sun
    • , Yunping Zhu
    • , Weimin Zhu
    • , Yi Wang
    • , Dong Yang
    • , Wanlin Liu
    • , Qiongming Liu
    • , Xiaoming Yang
    • , Bei Zhen
    • , Zhenyu Wu
    • , Jia Fan
    • , Huichuan Sun
    • , Juying Qian
    • , Tao Hong
    • , Lin Shen
    • , Baocai Xing
    • , Pengyuan Yang
    • , Huali Shen
    • , Lijuan Zhang
    • , Shujun Cheng
    • , Jianqiang Cai
    • , Xiaohang Zhao
    • , Yulin Sun
    • , Ting Xiao
    • , Yousheng Mao
    • , Xiangmei Chen
    • , Di Wu
    • , Lin Chen
    • , Jun Dong
    • , Haiteng Deng
    • , Minjia Tan
    • , Zhixing Wu
    • , Qingchuan Zhao
    • , Zhongyang Shen
    • , Xinguo Chen
    • , Youhe Gao
    • , Wei Sun
    • , Tong Wang
    • , Siqi Liu
    • , Liang Lin
    • , Jin Zi
    • , Xiaomin Lou
    • , Rong Zeng
    • , Yi Wu
    • , Sanjun Cai
    • , Bo Jiang
    • , Anqing Chen
    • , Zijian Li
    • , Fuquan Yang
    • , Xiulan Chen
    • , Yuna Sun
    • , Quanli Wang
    • , Yi Zhang
    • , Guangshun Wang
    • , Zhuchu Chen
    • , Weisong Qin
    •  & Zesong Li