Articles

  • Article |

    A bacterial family of cGAS/DncV-like nucleotidyltransferases synthesizes a diverse range of cyclic dinucleotide and trinucleotide compounds that are likely to modulate the interaction of both pathogens and commensal microbiota with their animal and plant hosts.

    • Aaron T. Whiteley
    • , James B. Eaglesham
    • , Carina C. de Oliveira Mann
    • , Benjamin R. Morehouse
    • , Brianna Lowey
    • , Eric A. Nieminen
    • , Olga Danilchanka
    • , David S. King
    • , Amy S. Y. Lee
    • , John J. Mekalanos
    •  & Philip J. Kranzusch
  • Article |

    In a rat model of multiple sclerosis, β-synuclein-specific T cells induce inflammation and pathological changes in the grey matter of the central nervous system; these cells were also found in higher numbers in patients with multiple sclerosis, particularly those with a chronic progressive course.

    • Dmitri Lodygin
    • , Moritz Hermann
    • , Nils Schweingruber
    • , Cassandra Flügel-Koch
    • , Takashi Watanabe
    • , Corinna Schlosser
    • , Arianna Merlini
    • , Henrike Körner
    • , Hsin-Fang Chang
    • , Henrike J. Fischer
    • , Holger M. Reichardt
    • , Marta Zagrebelsky
    • , Brit Mollenhauer
    • , Sebastian Kügler
    • , Dirk Fitzner
    • , Jens Frahm
    • , Christine Stadelmann
    • , Michael Haberl
    • , Francesca Odoardi
    •  & Alexander Flügel
  • Article |

    Single-cell profiling is used to create a molecular-level atlas of cell differentiation trajectories during gastrulation and early organogenesis in the mouse.

    • Blanca Pijuan-Sala
    • , Jonathan A. Griffiths
    • , Carolina Guibentif
    • , Tom W. Hiscock
    • , Wajid Jawaid
    • , Fernando J. Calero-Nieto
    • , Carla Mulas
    • , Ximena Ibarra-Soria
    • , Richard C. V. Tyser
    • , Debbie Lee Lian Ho
    • , Wolf Reik
    • , Shankar Srinivas
    • , Benjamin D. Simons
    • , Jennifer Nichols
    • , John C. Marioni
    •  & Berthold Göttgens
  • Article |

    Data from single-cell combinatorial-indexing RNA-sequencing analysis of 2 million cells from mouse embryos between embryonic days 9.5 and 13.5 are compiled in a cell atlas of mouse organogenesis, which provides a global view of developmental processes occurring during this critical period.

    • Junyue Cao
    • , Malte Spielmann
    • , Xiaojie Qiu
    • , Xingfan Huang
    • , Daniel M. Ibrahim
    • , Andrew J. Hill
    • , Fan Zhang
    • , Stefan Mundlos
    • , Lena Christiansen
    • , Frank J. Steemers
    • , Cole Trapnell
    •  & Jay Shendure
  • Article |

    Bilateral sensory stimulation, which is used to treat post-traumatic stress disorder in humans, alleviates fear memory in mice through a circuit involving the superior colliculus and the medial thalamus.

    • Jinhee Baek
    • , Sukchan Lee
    • , Taesup Cho
    • , Seong-Wook Kim
    • , Minsoo Kim
    • , Yongwoo Yoon
    • , Ko Keun Kim
    • , Junweon Byun
    • , Sang Jeong Kim
    • , Jaeseung Jeong
    •  & Hee-Sup Shin
  • Article |

    Islet non-β-cells from non-diabetic and diabetic human donors are modified via the transcription factors PDX1 and MAFA to produce and secrete insulin in response to glucose.

    • Kenichiro Furuyama
    • , Simona Chera
    • , Léon van Gurp
    • , Daniel Oropeza
    • , Luiza Ghila
    • , Nicolas Damond
    • , Heidrun Vethe
    • , Joao A. Paulo
    • , Antoinette M. Joosten
    • , Thierry Berney
    • , Domenico Bosco
    • , Craig Dorrell
    • , Markus Grompe
    • , Helge Ræder
    • , Bart O. Roep
    • , Fabrizio Thorel
    •  & Pedro L. Herrera
  • Article |

    Convergent estimates of nitrogen fixation from an inverse biogeochemical and a prognostic ocean model show that biological carbon export in the ocean is higher than expected and that stabilizing nitrogen-cycle feedbacks are weaker than we thought.

    • Wei-Lei Wang
    • , J. Keith Moore
    • , Adam C. Martiny
    •  & François W. Primeau
  • Article | | open

    The known species repertoire of the collective human gut microbiota is substantially expanded with the discovery of 1,952 uncultured bacterial species that greatly improve classification of understudied African and South American samples.

    • Alexandre Almeida
    • , Alex L. Mitchell
    • , Miguel Boland
    • , Samuel C. Forster
    • , Gregory B. Gloor
    • , Aleksandra Tarkowska
    • , Trevor D. Lawley
    •  & Robert D. Finn
  • Article |

    Increased meltwater from the Greenland and Antarctic ice sheets will slow the Atlantic overturning circulation and warm the subsurface ocean around Antarctica, further increasing Antarctic ice loss.

    • Nicholas R. Golledge
    • , Elizabeth D. Keller
    • , Natalya Gomez
    • , Kaitlin A. Naughten
    • , Jorge Bernales
    • , Luke D. Trusel
    •  & Tamsin L. Edwards
  • Article |

    By better quantifying uncertainties for marine ice-cliff instability, future Antarctic ice loss is predicted to be much lower than previously estimated.

    • Tamsin L. Edwards
    • , Mark A. Brandon
    • , Gael Durand
    • , Neil R. Edwards
    • , Nicholas R. Golledge
    • , Philip B. Holden
    • , Isabel J. Nias
    • , Antony J. Payne
    • , Catherine Ritz
    •  & Andreas Wernecke
  • Article |

    During cellular senescence in human and mouse cells, L1 transposons become transcriptionally derepressed and trigger a type-1 interferon response, which contributes to age-associated inflammation and age-related phenotypes.

    • Marco De Cecco
    • , Takahiro Ito
    • , Anna P. Petrashen
    • , Amy E. Elias
    • , Nicholas J. Skvir
    • , Steven W. Criscione
    • , Alberto Caligiana
    • , Greta Brocculi
    • , Emily M. Adney
    • , Jef D. Boeke
    • , Oanh Le
    • , Christian Beauséjour
    • , Jayakrishna Ambati
    • , Kameshwari Ambati
    • , Matthew Simon
    • , Andrei Seluanov
    • , Vera Gorbunova
    • , P. Eline Slagboom
    • , Stephen L. Helfand
    • , Nicola Neretti
    •  & John M. Sedivy
  • Article |

    Engineered dissipation is used to stabilize a Mott-insulator phase of photons trapped in a superconducting circuit, providing insights into thermalization processes in strongly correlated quantum matter.

    • Ruichao Ma
    • , Brendan Saxberg
    • , Clai Owens
    • , Nelson Leung
    • , Yao Lu
    • , Jonathan Simon
    •  & David I. Schuster
  • Article |

    Using a make-on-demand library that contains hundreds-of-millions of molecules, structure-based docking was used to identify compounds that, after synthesis and testing, are shown to interact with AmpC β-lactamase and the D4 dopamine receptor with high affinity.

    • Jiankun Lyu
    • , Sheng Wang
    • , Trent E. Balius
    • , Isha Singh
    • , Anat Levit
    • , Yurii S. Moroz
    • , Matthew J. O’Meara
    • , Tao Che
    • , Enkhjargal Algaa
    • , Kateryna Tolmachova
    • , Andrey A. Tolmachev
    • , Brian K. Shoichet
    • , Bryan L. Roth
    •  & John J. Irwin
  • Article |

    CRISPR–CasX represents a distinct RNA-guided platform that is functionally separate from Cas9 and Cas12a and is active for bacterial and human genome modification.

    • Jun-Jie Liu
    • , Natalia Orlova
    • , Benjamin L. Oakes
    • , Enbo Ma
    • , Hannah B. Spinner
    • , Katherine L. M. Baney
    • , Jonathan Chuck
    • , Dan Tan
    • , Gavin J. Knott
    • , Lucas B. Harrington
    • , Basem Al-Shayeb
    • , Alexander Wagner
    • , Julian Brötzmann
    • , Brett T. Staahl
    • , Kian L. Taylor
    • , John Desmarais
    • , Eva Nogales
    •  & Jennifer A. Doudna
  • Article |

    Optical dating of sediments from Denisova Cave establishes a chronology for its Pleistocene deposits and the associated artefacts, hominin remains and environmental records, which date to between about 300,000 and 20,000 years ago.

    • Zenobia Jacobs
    • , Bo Li
    • , Michael V. Shunkov
    • , Maxim B. Kozlikin
    • , Nataliya S. Bolikhovskaya
    • , Alexander K. Agadjanian
    • , Vladimir A. Uliyanov
    • , Sergei K. Vasiliev
    • , Kieran O’Gorman
    • , Anatoly P. Derevianko
    •  & Richard G. Roberts
  • Article |

    Adding reactive gases such as isoprene to mixtures lowers the production of secondary organic aerosol in the atmosphere, thus reducing the atmospheric particulate burden, with implications for human health and climate.

    • Gordon McFiggans
    • , Thomas F. Mentel
    • , Jürgen Wildt
    • , Iida Pullinen
    • , Sungah Kang
    • , Einhard Kleist
    • , Sebastian Schmitt
    • , Monika Springer
    • , Ralf Tillmann
    • , Cheng Wu
    • , Defeng Zhao
    • , Mattias Hallquist
    • , Cameron Faxon
    • , Michael Le Breton
    • , Åsa M. Hallquist
    • , David Simpson
    • , Robert Bergström
    • , Michael E. Jenkin
    • , Mikael Ehn
    • , Joel A. Thornton
    • , M. Rami Alfarra
    • , Thomas J. Bannan
    • , Carl J. Percival
    • , Michael Priestley
    • , David Topping
    •  & Astrid Kiendler-Scharr
  • Article |

    A statistical approach to designing and predicting the fusion yield of cryogenic deuterium–tritium implosions leads to tripled yield in direct-drive laser fusion of deuterium–tritium layered targets.

    • V. Gopalaswamy
    • , R. Betti
    • , J. P. Knauer
    • , N. Luciani
    • , D. Patel
    • , K. M. Woo
    • , A. Bose
    • , I. V. Igumenshchev
    • , E. M. Campbell
    • , K. S. Anderson
    • , K. A. Bauer
    • , M. J. Bonino
    • , D. Cao
    • , A. R. Christopherson
    • , G. W. Collins
    • , T. J. B. Collins
    • , J. R. Davies
    • , J. A. Delettrez
    • , D. H. Edgell
    • , R. Epstein
    • , C. J. Forrest
    • , D. H. Froula
    • , V. Y. Glebov
    • , V. N. Goncharov
    • , D. R. Harding
    • , S. X. Hu
    • , D. W. Jacobs-Perkins
    • , R. T. Janezic
    • , J. H. Kelly
    • , O. M. Mannion
    • , A. Maximov
    • , F. J. Marshall
    • , D. T. Michel
    • , S. Miller
    • , S. F. B. Morse
    • , J. Palastro
    • , J. Peebles
    • , P. B. Radha
    • , S. P. Regan
    • , S. Sampat
    • , T. C. Sangster
    • , A. B. Sefkow
    • , W. Seka
    • , R. C. Shah
    • , W. T. Shmyada
    • , A. Shvydky
    • , C. Stoeckl
    • , A. A. Solodov
    • , W. Theobald
    • , J. D. Zuegel
    • , M. Gatu Johnson
    • , R. D. Petrasso
    • , C. K. Li
    •  & J. A. Frenje
  • Article |

    The transcription factor PU.1 is an essential regulator of the pro-fibrotic gene expression program in fibroblasts; PU.1 expression is upregulated in various fibrotic diseases, whereas inactivation of PU.1 induces regression of fibrosis in a number of organs.

    • Thomas Wohlfahrt
    • , Simon Rauber
    • , Steffen Uebe
    • , Markus Luber
    • , Alina Soare
    • , Arif Ekici
    • , Stefanie Weber
    • , Alexandru-Emil Matei
    • , Chih-Wei Chen
    • , Christiane Maier
    • , Emmanuel Karouzakis
    • , Hans P. Kiener
    • , Elena Pachera
    • , Clara Dees
    • , Christian Beyer
    • , Christoph Daniel
    • , Kolja Gelse
    • , Andreas E. Kremer
    • , Elisabeth Naschberger
    • , Michael Stürzl
    • , Falk Butter
    • , Michael Sticherling
    • , Susetta Finotto
    • , Alexander Kreuter
    • , Mark H. Kaplan
    • , Astrid Jüngel
    • , Steffen Gay
    • , Stephen L. Nutt
    • , David W. Boykin
    • , Gregory M. K. Poon
    • , Oliver Distler
    • , Georg Schett
    • , Jörg H. W. Distler
    •  & Andreas Ramming
  • Article |

    A consortium of 11 bacterial strains from the healthy human gut microbiota can strongly induce interferon-γ-producing CD8 T cells in the intestine, and enhance both resistance to bacterial infection and the therapeutic efficacy of immune checkpoint inhibitors.

    • Takeshi Tanoue
    • , Satoru Morita
    • , Damian R. Plichta
    • , Ashwin N. Skelly
    • , Wataru Suda
    • , Yuki Sugiura
    • , Seiko Narushima
    • , Hera Vlamakis
    • , Iori Motoo
    • , Kayoko Sugita
    • , Atsushi Shiota
    • , Kozue Takeshita
    • , Keiko Yasuma-Mitobe
    • , Dieter Riethmacher
    • , Tsuneyasu Kaisho
    • , Jason M. Norman
    • , Daniel Mucida
    • , Makoto Suematsu
    • , Tomonori Yaguchi
    • , Vanni Bucci
    • , Takashi Inoue
    • , Yutaka Kawakami
    • , Bernat Olle
    • , Bruce Roberts
    • , Masahira Hattori
    • , Ramnik J. Xavier
    • , Koji Atarashi
    •  & Kenya Honda
  • Article |

    The current phase of subduction of the Nazca slab was established in the Peruvian Andes after a plate reorganization around 80 million years ago and then propagated progressively southwards.

    • Yi-Wei Chen
    • , Jonny Wu
    •  & John Suppe
  • Article |

    The activation mechanism of metabotropic glutamate receptor subtype 5, a member of the family C G-protein-coupled receptors, is characterized by a combination of cryo-electron microscopy, crystallography and signalling studies.

    • Antoine Koehl
    • , Hongli Hu
    • , Dan Feng
    • , Bingfa Sun
    • , Yan Zhang
    • , Michael J. Robertson
    • , Matthew Chu
    • , Tong Sun Kobilka
    • , Toon Laermans
    • , Jan Steyaert
    • , Jeffrey Tarrasch
    • , Somnath Dutta
    • , Rasmus Fonseca
    • , William I. Weis
    • , Jesper M. Mathiesen
    • , Georgios Skiniotis
    •  & Brian K. Kobilka
  • Article |

    Inspired by the enhanced mechanical strength of microstructured metals, damage-tolerant architected materials are developed in which the internal structure is granular, with different regions having different lattice orientations.

    • Minh-Son Pham
    • , Chen Liu
    • , Iain Todd
    •  & Jedsada Lertthanasarn
  • Article |

    Transcriptomic and genetic analyses of a deletion set of all known introns in genes of the budding yeast Saccharomyces cerevisiae indicate that introns promote resistance to starvation.

    • Julie Parenteau
    • , Laurine Maignon
    • , Mélodie Berthoumieux
    • , Mathieu Catala
    • , Vanessa Gagnon
    •  & Sherif Abou Elela
  • Article |

    A set of 34 excised introns in Saccharomyces cerevisiae, characterized by having a short distance between the lariat branch point and the 3′ splice site, have a biological function within the TOR growth-signalling network.

    • Jeffrey T. Morgan
    • , Gerald R. Fink
    •  & David P. Bartel
  • Article |

    A hyper-stable de novo protein mimic of interleukin-2 computationally designed to not interact with a regulatory T-cell specific receptor subunit has improved therapeutic activity in mouse models of melanoma and colon cancer.

    • Daniel-Adriano Silva
    • , Shawn Yu
    • , Umut Y. Ulge
    • , Jamie B. Spangler
    • , Kevin M. Jude
    • , Carlos Labão-Almeida
    • , Lestat R. Ali
    • , Alfredo Quijano-Rubio
    • , Mikel Ruterbusch
    • , Isabel Leung
    • , Tamara Biary
    • , Stephanie J. Crowley
    • , Enrique Marcos
    • , Carl D. Walkey
    • , Brian D. Weitzner
    • , Fátima Pardo-Avila
    • , Javier Castellanos
    • , Lauren Carter
    • , Lance Stewart
    • , Stanley R. Riddell
    • , Marion Pepper
    • , Gonçalo J. L. Bernardes
    • , Michael Dougan
    • , K. Christopher Garcia
    •  & David Baker
  • Article |

    In physiologically normal epithelia, age-related expansion of clones that carry mutations in NOTCH1 and other driver genes is accelerated by risk factors for developing oesophageal squamous cell carcinoma, such as alcohol consumption or smoking.

    • Akira Yokoyama
    • , Nobuyuki Kakiuchi
    • , Tetsuichi Yoshizato
    • , Yasuhito Nannya
    • , Hiromichi Suzuki
    • , Yasuhide Takeuchi
    • , Yusuke Shiozawa
    • , Yusuke Sato
    • , Kosuke Aoki
    • , Soo Ki Kim
    • , Yoichi Fujii
    • , Kenichi Yoshida
    • , Keisuke Kataoka
    • , Masahiro M. Nakagawa
    • , Yoshikage Inoue
    • , Tomonori Hirano
    • , Yuichi Shiraishi
    • , Kenichi Chiba
    • , Hiroko Tanaka
    • , Masashi Sanada
    • , Yoshitaka Nishikawa
    • , Yusuke Amanuma
    • , Shinya Ohashi
    • , Ikuo Aoyama
    • , Takahiro Horimatsu
    • , Shin’ichi Miyamoto
    • , Shigeru Tsunoda
    • , Yoshiharu Sakai
    • , Maiko Narahara
    • , J. B. Brown
    • , Yoshitaka Sato
    • , Genta Sawada
    • , Koshi Mimori
    • , Sachiko Minamiguchi
    • , Hironori Haga
    • , Hiroshi Seno
    • , Satoru Miyano
    • , Hideki Makishima
    • , Manabu Muto
    •  & Seishi Ogawa
  • Article |

    Cryo-electron microscopy structures are reported in which the full-length human α1β3γ2L GABAA receptor in lipid nanodiscs is bound to the channel-blocker picrotoxin, the competitive antagonist bicuculline, the agonist GABA, and the benzodiazepines alprazolam and diazepam.

    • Simonas Masiulis
    • , Rooma Desai
    • , Tomasz Uchański
    • , Itziar Serna Martin
    • , Duncan Laverty
    • , Dimple Karia
    • , Tomas Malinauskas
    • , Jasenko Zivanov
    • , Els Pardon
    • , Abhay Kotecha
    • , Jan Steyaert
    • , Keith W. Miller
    •  & A. Radu Aricescu
  • Article |

    The cryo-electron microscopy structure of human γ-secretase in complex with its substrate Notch reveals pronounced structural rearrangements compared to the apo enzyme, including formation of a β-sheet involving residues from both enzyme and substrate.

    • Guanghui Yang
    • , Rui Zhou
    • , Qiang Zhou
    • , Xuefei Guo
    • , Chuangye Yan
    • , Meng Ke
    • , Jianlin Lei
    •  & Yigong Shi
  • Article |

    The mouse develops a developmentally and functionally distinct, non-canonical beige fat cell type as an adaptation to cold ambient temperature.

    • Yong Chen
    • , Kenji Ikeda
    • , Takeshi Yoneshiro
    • , Annarita Scaramozza
    • , Kazuki Tajima
    • , Qiang Wang
    • , Kyeongkyu Kim
    • , Kosaku Shinoda
    • , Carlos Henrique Sponton
    • , Zachary Brown
    • , Andrew Brack
    •  & Shingo Kajimura
  • Article |

    In mice, synaptic potentiation of transmission from the orbitofrontal cortex to the dorsal striatum drives compulsive reinforcement, a defining symptom of addiction.

    • Vincent Pascoli
    • , Agnès Hiver
    • , Ruud Van Zessen
    • , Michaël Loureiro
    • , Ridouane Achargui
    • , Masaya Harada
    • , Jérôme Flakowski
    •  & Christian Lüscher
  • Article |

    Deletion of the A-to-I double-stranded RNA-editing enzyme ADAR1 sensitizes tumour cells to immunotherapy.

    • Jeffrey J. Ishizuka
    • , Robert T. Manguso
    • , Collins K. Cheruiyot
    • , Kevin Bi
    • , Arpit Panda
    • , Arvin Iracheta-Vellve
    • , Brian C. Miller
    • , Peter P. Du
    • , Kathleen B. Yates
    • , Juan Dubrot
    • , Ilana Buchumenski
    • , Dawn E. Comstock
    • , Flavian D. Brown
    • , Austin Ayer
    • , Ian C. Kohnle
    • , Hans W. Pope
    • , Margaret D. Zimmer
    • , Debattama R. Sen
    • , Sarah K. Lane-Reticker
    • , Emily J. Robitschek
    • , Gabriel K. Griffin
    • , Natalie B. Collins
    • , Adrienne H. Long
    • , John G. Doench
    • , David Kozono
    • , Erez Y. Levanon
    •  & W. Nicholas Haining
  • Article |

    Despite inter-model differences in predicting the details of the eastern Pacific El Niño, a robust increase in the corresponding sea surface temperature variability under greenhouse warming is found across models.

    • Wenju Cai
    • , Guojian Wang
    • , Boris Dewitte
    • , Lixin Wu
    • , Agus Santoso
    • , Ken Takahashi
    • , Yun Yang
    • , Aude Carréric
    •  & Michael J. McPhaden
  • Article |

    Cryo-electron microscopy structures of connexin channels composed of connexin 46 and connexin 50 in an open-state reveal features that govern permselectivity and the location of mutated residues linked to herediatry cataracts.

    • Janette B. Myers
    • , Bassam G. Haddad
    • , Susan E. O’Neill
    • , Dror S. Chorev
    • , Craig C. Yoshioka
    • , Carol V. Robinson
    • , Daniel M. Zuckerman
    •  & Steve L. Reichow
  • Article |

    The cryo-electron microscopy structure of the gp120 component of the HIV-1 envelope glycoprotein, in complex with the primary receptor CD4 and coreceptor CCR5, provides insight into the cell-entry mechanism of HIV-1.

    • Md Munan Shaik
    • , Hanqin Peng
    • , Jianming Lu
    • , Sophia Rits-Volloch
    • , Chen Xu
    • , Maofu Liao
    •  & Bing Chen
  • Article |

    Combinatorial tagging of single cells using expressed DNA barcodes, delivered by a lentiviral vector, is used to track individual cells and reconstruct their lineages and trajectories during cell fate reprogramming.

    • Brent A. Biddy
    • , Wenjun Kong
    • , Kenji Kamimoto
    • , Chuner Guo
    • , Sarah E. Waye
    • , Tao Sun
    •  & Samantha A. Morris
  • Article |

    The presence of blubber and distribution of melanophores in a countershading pattern in an Early Jurassic ichthyosaur demonstrate that the evolutionary convergence of these reptiles with extant marine amniotes extends to the cellular and molecular levels.

    • Johan Lindgren
    • , Peter Sjövall
    • , Volker Thiel
    • , Wenxia Zheng
    • , Shosuke Ito
    • , Kazumasa Wakamatsu
    • , Rolf Hauff
    • , Benjamin P. Kear
    • , Anders Engdahl
    • , Carl Alwmark
    • , Mats E. Eriksson
    • , Martin Jarenmark
    • , Sven Sachs
    • , Per E. Ahlberg
    • , Federica Marone
    • , Takeo Kuriyama
    • , Ola Gustafsson
    • , Per Malmberg
    • , Aurélien Thomen
    • , Irene Rodríguez-Meizoso
    • , Per Uvdal
    • , Makoto Ojika
    •  & Mary H. Schweitzer
  • Article |

    Pyramidal neurons in the hippocampal CA2 region in mice promote social aggression via a disinhibitory circuit involving the lateral septum and ventromedial hypothalamus.

    • Felix Leroy
    • , Jung Park
    • , Arun Asok
    • , David H. Brann
    • , Torcato Meira
    • , Lara M. Boyle
    • , Eric W. Buss
    • , Eric R. Kandel
    •  & Steven A. Siegelbaum
  • Article |

    A scalable spintronic device operating via spin–orbit transduction and magnetoelectric switching and using advanced quantum materials shows non-volatility and improved performance and energy efficiency compared with CMOS devices.

    • Sasikanth Manipatruni
    • , Dmitri E. Nikonov
    • , Chia-Ching Lin
    • , Tanay A. Gosavi
    • , Huichu Liu
    • , Bhagwati Prasad
    • , Yen-Lin Huang
    • , Everton Bonturim
    • , Ramamoorthy Ramesh
    •  & Ian A. Young
  • Article |

    The gene for the amyloid precursor protein (APP) shows somatic gene recombination in neurons, and the abundance and diversity of APP variants is increased in neurons from individuals with Alzheimer’s disease.

    • Ming-Hsiang Lee
    • , Benjamin Siddoway
    • , Gwendolyn E. Kaeser
    • , Igor Segota
    • , Richard Rivera
    • , William J. Romanow
    • , Christine S. Liu
    • , Chris Park
    • , Grace Kennedy
    • , Tao Long
    •  & Jerold Chun
  • Article |

    The plant F-box protein D3 has a C-terminal α-helix that switches between two conformational states, allowing the α/β hydrolase D14 to recruit the transcription repressor D53 for strigolactone-dependent degradation.

    • Nitzan Shabek
    • , Fabrizio Ticchiarelli
    • , Haibin Mao
    • , Thomas R. Hinds
    • , Ottoline Leyser
    •  & Ning Zheng
  • Article | | open

    Genomic, epigenomic and transcriptomic data derived from the Mediterranean amphioxus (Branchiostoma lanceolatum) provide insights into the evolution of the genomic regulatory landscape of chordates.

    • Ferdinand Marlétaz
    • , Panos N. Firbas
    • , Ignacio Maeso
    • , Juan J. Tena
    • , Ozren Bogdanovic
    • , Malcolm Perry
    • , Christopher D. R. Wyatt
    • , Elisa de la Calle-Mustienes
    • , Stephanie Bertrand
    • , Demian Burguera
    • , Rafael D. Acemel
    • , Simon J. van Heeringen
    • , Silvia Naranjo
    • , Carlos Herrera-Ubeda
    • , Ksenia Skvortsova
    • , Sandra Jimenez-Gancedo
    • , Daniel Aldea
    • , Yamile Marquez
    • , Lorena Buono
    • , Iryna Kozmikova
    • , Jon Permanyer
    • , Alexandra Louis
    • , Beatriz Albuixech-Crespo
    • , Yann Le Petillon
    • , Anthony Leon
    • , Lucie Subirana
    • , Piotr J. Balwierz
    • , Paul Edward Duckett
    • , Ensieh Farahani
    • , Jean-Marc Aury
    • , Sophie Mangenot
    • , Patrick Wincker
    • , Ricard Albalat
    • , Èlia Benito-Gutiérrez
    • , Cristian Cañestro
    • , Filipe Castro
    • , Salvatore D’Aniello
    • , David E. K. Ferrier
    • , Shengfeng Huang
    • , Vincent Laudet
    • , Gabriel A. B. Marais
    • , Pierre Pontarotti
    • , Michael Schubert
    • , Hervé Seitz
    • , Ildiko Somorjai
    • , Tokiharu Takahashi
    • , Olivier Mirabeau
    • , Anlong Xu
    • , Jr-Kai Yu
    • , Piero Carninci
    • , Juan Ramon Martinez-Morales
    • , Hugues Roest Crollius
    • , Zbynek Kozmik
    • , Matthew T. Weirauch
    • , Jordi Garcia-Fernàndez
    • , Ryan Lister
    • , Boris Lenhard
    • , Peter W. H. Holland
    • , Hector Escriva
    • , Jose Luis Gómez-Skarmeta
    •  & Manuel Irimia
  • Article |

    Accounting for meltwater from the Antarctic Ice Sheet in simulations of global climate leads to substantial changes in future climate projections and identifies a potential feedback mechanism that exacerbates melting.

    • Ben Bronselaer
    • , Michael Winton
    • , Stephen M. Griffies
    • , William J. Hurlin
    • , Keith B. Rodgers
    • , Olga V. Sergienko
    • , Ronald J. Stouffer
    •  & Joellen L. Russell
  • Article |

    Transcriptomes of about 70,000 single cells from first-trimester deciduas and placentas reveal subsets of perivascular, stromal and natural killer cells in the decidua, with distinct immunomodulatory profiles that regulate the environment necessary for successful placentation.

    • Roser Vento-Tormo
    • , Mirjana Efremova
    • , Rachel A. Botting
    • , Margherita Y. Turco
    • , Miquel Vento-Tormo
    • , Kerstin B. Meyer
    • , Jong-Eun Park
    • , Emily Stephenson
    • , Krzysztof Polański
    • , Angela Goncalves
    • , Lucy Gardner
    • , Staffan Holmqvist
    • , Johan Henriksson
    • , Angela Zou
    • , Andrew M. Sharkey
    • , Ben Millar
    • , Barbara Innes
    • , Laura Wood
    • , Anna Wilbrey-Clark
    • , Rebecca P. Payne
    • , Martin A. Ivarsson
    • , Steve Lisgo
    • , Andrew Filby
    • , David H. Rowitch
    • , Judith N. Bulmer
    • , Gavin J. Wright
    • , Michael J. T. Stubbington
    • , Muzlifah Haniffa
    • , Ashley Moffett
    •  & Sarah A. Teichmann
  • Article | | open

    An improved, fully re-annotated Aedes aegypti genome assembly (AaegL5) provides insights into the sex-determining M locus, chemosensory systems that help mosquitoes to hunt humans and loci involved in insecticide resistance and will help to generate intervention strategies to fight this deadly disease vector.

    • Benjamin J. Matthews
    • , Olga Dudchenko
    • , Sarah B. Kingan
    • , Sergey Koren
    • , Igor Antoshechkin
    • , Jacob E. Crawford
    • , William J. Glassford
    • , Margaret Herre
    • , Seth N. Redmond
    • , Noah H. Rose
    • , Gareth D. Weedall
    • , Yang Wu
    • , Sanjit S. Batra
    • , Carlos A. Brito-Sierra
    • , Steven D. Buckingham
    • , Corey L. Campbell
    • , Saki Chan
    • , Eric Cox
    • , Benjamin R. Evans
    • , Thanyalak Fansiri
    • , Igor Filipović
    • , Albin Fontaine
    • , Andrea Gloria-Soria
    • , Richard Hall
    • , Vinita S. Joardar
    • , Andrew K. Jones
    • , Raissa G. G. Kay
    • , Vamsi K. Kodali
    • , Joyce Lee
    • , Gareth J. Lycett
    • , Sara N. Mitchell
    • , Jill Muehling
    • , Michael R. Murphy
    • , Arina D. Omer
    • , Frederick A. Partridge
    • , Paul Peluso
    • , Aviva Presser Aiden
    • , Vidya Ramasamy
    • , Gordana Rašić
    • , Sourav Roy
    • , Karla Saavedra-Rodriguez
    • , Shruti Sharan
    • , Atashi Sharma
    • , Melissa Laird Smith
    • , Joe Turner
    • , Allison M. Weakley
    • , Zhilei Zhao
    • , Omar S. Akbari
    • , William C. Black IV
    • , Han Cao
    • , Alistair C. Darby
    • , Catherine A. Hill
    • , J. Spencer Johnston
    • , Terence D. Murphy
    • , Alexander S. Raikhel
    • , David B. Sattelle
    • , Igor V. Sharakhov
    • , Bradley J. White
    • , Li Zhao
    • , Erez Lieberman Aiden
    • , Richard S. Mann
    • , Louis Lambrechts
    • , Jeffrey R. Powell
    • , Maria V. Sharakhova
    • , Zhijian Tu
    • , Hugh M. Robertson
    • , Carolyn S. McBride
    • , Alex R. Hastie
    • , Jonas Korlach
    • , Daniel E. Neafsey
    • , Adam M. Phillippy
    •  & Leslie B. Vosshall
  • Article |

    With global warming, Andean forests are changing to include more trees of low-elevation, heat-loving species but rates of compositional change are not uniform across elevations and are insufficient to keep species in equilibrium with climate.

    • Belén Fadrique
    • , Selene Báez
    • , Álvaro Duque
    • , Agustina Malizia
    • , Cecilia Blundo
    • , Julieta Carilla
    • , Oriana Osinaga-Acosta
    • , Lucio Malizia
    • , Miles Silman
    • , William Farfán-Ríos
    • , Yadvinder Malhi
    • , Kenneth R. Young
    • , Francisco Cuesta C.
    • , Jurgen Homeier
    • , Manuel Peralvo
    • , Esteban Pinto
    • , Oswaldo Jadan
    • , Nikolay Aguirre
    • , Zhofre Aguirre
    •  & Kenneth J. Feeley
  • Article |

    Climate model simulations reveal that recent destructive tropical cyclones would have been equally intense in terms of wind speed but would have produced less rainfall if these events had occurred in pre-industrial climates, and in future climates they would have greater wind speeds and rainfall.

    • Christina M. Patricola
    •  & Michael F. Wehner