Articles

  • Article |

    ANKRD16 attenuates neurodegeneration induced by a mutation in the editing domain of alanyl tRNA synthetase by directly accepting mis-activated serine from the synthetase before transfer to the tRNA, establishing a new mechanism by which editing defects are prevented.

    • My-Nuong Vo
    • , Markus Terrey
    • , Jeong Woong Lee
    • , Bappaditya Roy
    • , James J. Moresco
    • , Litao Sun
    • , Hongjun Fu
    • , Qi Liu
    • , Thomas G. Weber
    • , John R. Yates III
    • , Kurt Fredrick
    • , Paul Schimmel
    •  & Susan L. Ackerman
  • Article |

    The structure of a homomeric channel of subunit A of leucine-rich repeat-containing protein 8 (LRRC8) determined by cryo-electron microscopy and X-ray crystallography reveals the basis for anion selectivity.

    • Dawid Deneka
    • , Marta Sawicka
    • , Andy K. M. Lam
    • , Cristina Paulino
    •  & Raimund Dutzler
  • Article |

    ZNFX-1 and WAGO-4 localize to germ granules in early C. elegans embryogenesis and later separate to form independent liquid-like droplets, and the temporal and spatial ordering of these droplets may help cells to organize complex RNA processing pathways.

    • Gang Wan
    • , Brandon D. Fields
    • , George Spracklin
    • , Aditi Shukla
    • , Carolyn M. Phillips
    •  & Scott Kennedy
  • Article |

    A large-scale mutagenesis screen identifies mutant phenotypes for over 11,000 protein-coding genes in bacteria that had previously not been assigned a specific function.

    • Morgan N. Price
    • , Kelly M. Wetmore
    • , R. Jordan Waters
    • , Mark Callaghan
    • , Jayashree Ray
    • , Hualan Liu
    • , Jennifer V. Kuehl
    • , Ryan A. Melnyk
    • , Jacob S. Lamson
    • , Yumi Suh
    • , Hans K. Carlson
    • , Zuelma Esquivel
    • , Harini Sadeeshkumar
    • , Romy Chakraborty
    • , Grant M. Zane
    • , Benjamin E. Rubin
    • , Judy D. Wall
    • , Axel Visel
    • , James Bristow
    • , Matthew J. Blow
    • , Adam P. Arkin
    •  & Adam M. Deutschbauer
  • Article |

    A screen in which combinatorial pairs of transcription factors are exogenously expressed in fibroblasts identifies different combinations that reprogram these cells into induced neuronal cells with diverse functional properties.

    • Rachel Tsunemoto
    • , Sohyon Lee
    • , Attila Szűcs
    • , Pavel Chubukov
    • , Irina Sokolova
    • , Joel W. Blanchard
    • , Kevin T. Eade
    • , Jacob Bruggemann
    • , Chunlei Wu
    • , Ali Torkamani
    • , Pietro Paolo Sanna
    •  & Kristin K. Baldwin
  • Article |

    Sequences of 137 ancient and 502 modern human genomes illuminate the population history of the Eurasian steppes after the Bronze Age and document the replacement of Indo-European speakers of West Eurasian ancestry by Turkic-speaking groups of East Asian ancestry.

    • Peter de Barros Damgaard
    • , Nina Marchi
    • , Simon Rasmussen
    • , Michaël Peyrot
    • , Gabriel Renaud
    • , Thorfinn Korneliussen
    • , J. Víctor Moreno-Mayar
    • , Mikkel Winther Pedersen
    • , Amy Goldberg
    • , Emma Usmanova
    • , Nurbol Baimukhanov
    • , Valeriy Loman
    • , Lotte Hedeager
    • , Anders Gorm Pedersen
    • , Kasper Nielsen
    • , Gennady Afanasiev
    • , Kunbolot Akmatov
    • , Almaz Aldashev
    • , Ashyk Alpaslan
    • , Gabit Baimbetov
    • , Vladimir I. Bazaliiskii
    • , Arman Beisenov
    • , Bazartseren Boldbaatar
    • , Bazartseren Boldgiv
    • , Choduraa Dorzhu
    • , Sturla Ellingvag
    • , Diimaajav Erdenebaatar
    • , Rana Dajani
    • , Evgeniy Dmitriev
    • , Valeriy Evdokimov
    • , Karin M. Frei
    • , Andrey Gromov
    • , Alexander Goryachev
    • , Hakon Hakonarson
    • , Tatyana Hegay
    • , Zaruhi Khachatryan
    • , Ruslan Khaskhanov
    • , Egor Kitov
    • , Alina Kolbina
    • , Tabaldiev Kubatbek
    • , Alexey Kukushkin
    • , Igor Kukushkin
    • , Nina Lau
    • , Ashot Margaryan
    • , Inga Merkyte
    • , Ilya V. Mertz
    • , Viktor K. Mertz
    • , Enkhbayar Mijiddorj
    • , Vyacheslav Moiyesev
    • , Gulmira Mukhtarova
    • , Bekmukhanbet Nurmukhanbetov
    • , Z. Orozbekova
    • , Irina Panyushkina
    • , Karol Pieta
    • , Václav Smrčka
    • , Irina Shevnina
    • , Andrey Logvin
    • , Karl-Göran Sjögren
    • , Tereza Štolcová
    • , Kadicha Tashbaeva
    • , Alexander Tkachev
    • , Turaly Tulegenov
    • , Dmitriy Voyakin
    • , Levon Yepiskoposyan
    • , Sainbileg Undrakhbold
    • , Victor Varfolomeev
    • , Andrzej Weber
    • , Nikolay Kradin
    • , Morten E. Allentoft
    • , Ludovic Orlando
    • , Rasmus Nielsen
    • , Martin Sikora
    • , Evelyne Heyer
    • , Kristian Kristiansen
    •  & Eske Willerslev
  • Article |

    Crystal structures of the ABC transporter MsbA in complex with two selective small-molecule antagonists reveal an unprecedented allosteric mechanism of inhibition.

    • Hoangdung Ho
    • , Anh Miu
    • , Mary Kate Alexander
    • , Natalie K. Garcia
    • , Angela Oh
    • , Inna Zilberleyb
    • , Mike Reichelt
    • , Cary D. Austin
    • , Christine Tam
    • , Stephanie Shriver
    • , Huiyong Hu
    • , Sharada S. Labadie
    • , Jun Liang
    • , Lan Wang
    • , Jian Wang
    • , Yan Lu
    • , Hans E. Purkey
    • , John Quinn
    • , Yvonne Franke
    • , Kevin Clark
    • , Maureen H. Beresini
    • , Man-Wah Tan
    • , Benjamin D. Sellers
    • , Till Maurer
    • , Michael F. T. Koehler
    • , Aaron T. Wecksler
    • , James R. Kiefer
    • , Vishal Verma
    • , Yiming Xu
    • , Mireille Nishiyama
    • , Jian Payandeh
    •  & Christopher M. Koth
  • Article |

    Transient engagement of the G protein-coupled receptor core can act as a catalyst to activate cellular β-arrestin function after dissociation from the receptor.

    • Kelsie Eichel
    • , Damien Jullié
    • , Benjamin Barsi-Rhyne
    • , Naomi R. Latorraca
    • , Matthieu Masureel
    • , Jean-Baptiste Sibarita
    • , Ron O. Dror
    •  & Mark von Zastrow
  • Article |

    In mouse models of Parkinson’s disease and dyskinesia, striatal spiny projection neurons of the direct and indirect pathways have abnormal, imbalanced levels of spontaneous and locomotor-related activity, with the two different disease states characterized by opposite abnormalities.

    • Jones G. Parker
    • , Jesse D. Marshall
    • , Biafra Ahanonu
    • , Yu-Wei Wu
    • , Tony Hyun Kim
    • , Benjamin F. Grewe
    • , Yanping Zhang
    • , Jin Zhong Li
    • , Jun B. Ding
    • , Michael D. Ehlers
    •  & Mark J. Schnitzer
  • Article |

    Cooperation between a chiral hydrogen-bond-donor catalyst and a strong Lewis-acid promoter in an SN1-type reaction mediates the formation of tertiary carbocations and enables control over enantioselectivity and product distribution.

    • Alison E. Wendlandt
    • , Prithvi Vangal
    •  & Eric N. Jacobsen
  • Article |

    High-resolution cryo-electron microscopy structures of the membrane-pore-forming domain of the mouse gasdermin GSDMA3 show that it forms pores with 26-, 27- or 28-fold symmetry and indicate that it may also form a parallel, soluble, pre-pore ring structure.

    • Jianbin Ruan
    • , Shiyu Xia
    • , Xing Liu
    • , Judy Lieberman
    •  & Hao Wu
  • Article | | open

    Analyses of genetic variation and population structure based on over 3,000 cultivated rice (Oryza sativa) genomes reveal subpopulations that correlate with geographic location and patterns of introgression consistent with multiple rice domestication events.

    • Wensheng Wang
    • , Ramil Mauleon
    • , Zhiqiang Hu
    • , Dmytro Chebotarov
    • , Shuaishuai Tai
    • , Zhichao Wu
    • , Min Li
    • , Tianqing Zheng
    • , Roven Rommel Fuentes
    • , Fan Zhang
    • , Locedie Mansueto
    • , Dario Copetti
    • , Millicent Sanciangco
    • , Kevin Christian Palis
    • , Jianlong Xu
    • , Chen Sun
    • , Binying Fu
    • , Hongliang Zhang
    • , Yongming Gao
    • , Xiuqin Zhao
    • , Fei Shen
    • , Xiao Cui
    • , Hong Yu
    • , Zichao Li
    • , Miaolin Chen
    • , Jeffrey Detras
    • , Yongli Zhou
    • , Xinyuan Zhang
    • , Yue Zhao
    • , Dave Kudrna
    • , Chunchao Wang
    • , Rui Li
    • , Ben Jia
    • , Jinyuan Lu
    • , Xianchang He
    • , Zhaotong Dong
    • , Jiabao Xu
    • , Yanhong Li
    • , Miao Wang
    • , Jianxin Shi
    • , Jing Li
    • , Dabing Zhang
    • , Seunghee Lee
    • , Wushu Hu
    • , Alexander Poliakov
    • , Inna Dubchak
    • , Victor Jun Ulat
    • , Frances Nikki Borja
    • , John Robert Mendoza
    • , Jauhar Ali
    • , Jing Li
    • , Qiang Gao
    • , Yongchao Niu
    • , Zhen Yue
    • , Ma. Elizabeth B. Naredo
    • , Jayson Talag
    • , Xueqiang Wang
    • , Jinjie Li
    • , Xiaodong Fang
    • , Ye Yin
    • , Jean-Christophe Glaszmann
    • , Jianwei Zhang
    • , Jiayang Li
    • , Ruaraidh Sackville Hamilton
    • , Rod A. Wing
    • , Jue Ruan
    • , Gengyun Zhang
    • , Chaochun Wei
    • , Nickolai Alexandrov
    • , Kenneth L. McNally
    • , Zhikang Li
    •  & Hei Leung
  • Article |

    A cryo-electron microscopy structure of the substrate-bound human telomerase holoenzyme, which lengthens the protective caps on chromosomes.

    • Thi Hoang Duong Nguyen
    • , Jane Tam
    • , Robert A. Wu
    • , Basil J. Greber
    • , Daniel Toso
    • , Eva Nogales
    •  & Kathleen Collins
  • Article |

    Laser spectroscopy is used to investigate the hyperfine structure and determine the fundamental nuclear properties of the isomer 229mTh, the strongest candidate for the realization of a nuclear clock.

    • Johannes Thielking
    • , Maxim V. Okhapkin
    • , Przemysław Głowacki
    • , David M. Meier
    • , Lars von der Wense
    • , Benedict Seiferle
    • , Christoph E. Düllmann
    • , Peter G. Thirolf
    •  & Ekkehard Peik
  • Article |

    Epithelial-to-mesenchymal transition in tumour cells occurs through distinct intermediate states, associated with different metastatic potential, cellular properties, gene expression, and chromatin landscape

    • Ievgenia Pastushenko
    • , Audrey Brisebarre
    • , Alejandro Sifrim
    • , Marco Fioramonti
    • , Tatiana Revenco
    • , Soufiane Boumahdi
    • , Alexandra Van Keymeulen
    • , Daniel Brown
    • , Virginie Moers
    • , Sophie Lemaire
    • , Sarah De Clercq
    • , Esmeralda Minguijón
    • , Cédric Balsat
    • , Youri Sokolow
    • , Christine Dubois
    • , Florian De Cock
    • , Samuel Scozzaro
    • , Federico Sopena
    • , Angel Lanas
    • , Nicky D’Haene
    • , Isabelle Salmon
    • , Jean-Christophe Marine
    • , Thierry Voet
    • , Panagiota A. Sotiropoulou
    •  & Cédric Blanpain
  • Article |

    A new version of the phylogenetic bootstrap method enables assessment of the robustness of phylogenies that are based on large datasets of hundreds or thousands of taxa.

    • F. Lemoine
    • , J.-B. Domelevo Entfellner
    • , E. Wilkinson
    • , D. Correia
    • , M. Dávila Felipe
    • , T. De Oliveira
    •  & O. Gascuel
  • Article |

    SAMHD1 has an essential role in the replication stress response and prevents inflammation by activating the MRE11 nuclease to degrade nascent DNA strands at stalled replication forks, thus enabling replication.

    • Flavie Coquel
    • , Maria-Joao Silva
    • , Hervé Técher
    • , Karina Zadorozhny
    • , Sushma Sharma
    • , Jadwiga Nieminuszczy
    • , Clément Mettling
    • , Elodie Dardillac
    • , Antoine Barthe
    • , Anne-Lyne Schmitz
    • , Alexy Promonet
    • , Alexandra Cribier
    • , Amélie Sarrazin
    • , Wojciech Niedzwiedz
    • , Bernard Lopez
    • , Vincenzo Costanzo
    • , Lumir Krejci
    • , Andrei Chabes
    • , Monsef Benkirane
    • , Yea-Lih Lin
    •  & Philippe Pasero
  • Article |

    Normothermic machine perfusion of the liver improved early graft function, demonstrated by reduced peak serum aspartate transaminase levels and early allograft dysfunction rates, and improved organ utilization and preservation times, although no differences were seen in graft or patient survival.

    • David Nasralla
    • , Constantin C. Coussios
    • , Hynek Mergental
    • , M. Zeeshan Akhtar
    • , Andrew J. Butler
    • , Carlo D. L. Ceresa
    • , Virginia Chiocchia
    • , Susan J. Dutton
    • , Juan Carlos García-Valdecasas
    • , Nigel Heaton
    • , Charles Imber
    • , Wayel Jassem
    • , Ina Jochmans
    • , John Karani
    • , Simon R. Knight
    • , Peri Kocabayoglu
    • , Massimo Malagò
    • , Darius Mirza
    • , Peter J. Morris
    • , Arvind Pallan
    • , Andreas Paul
    • , Mihai Pavel
    • , M. Thamara P. R. Perera
    • , Jacques Pirenne
    • , Reena Ravikumar
    • , Leslie Russell
    • , Sara Upponi
    • , Chris J. E. Watson
    • , Annemarie Weissenbacher
    • , Rutger J. Ploeg
    •  & Peter J. Friend
  • Article |

    Peripheral stimuli can induce acute immune training and tolerance in the brain and lead to long-lasting epigenetic reprogramming of microglia; these changes alter pathology in mouse models of stroke and Alzheimer’s pathology .

    • Ann-Christin Wendeln
    • , Karoline Degenhardt
    • , Lalit Kaurani
    • , Michael Gertig
    • , Thomas Ulas
    • , Gaurav Jain
    • , Jessica Wagner
    • , Lisa M. Häsler
    • , Katleen Wild
    • , Angelos Skodras
    • , Thomas Blank
    • , Ori Staszewski
    • , Moumita Datta
    • , Tonatiuh Pena Centeno
    • , Vincenzo Capece
    • , Md. Rezaul Islam
    • , Cemil Kerimoglu
    • , Matthias Staufenbiel
    • , Joachim L. Schultze
    • , Marc Beyer
    • , Marco Prinz
    • , Mathias Jucker
    • , André Fischer
    •  & Jonas J. Neher
  • Article | | open

    Whole-genome sequencing of 1,011 natural isolates of the yeast Saccharomyces cerevisiae reveals its evolutionary history, including a single out-of-China origin and multiple domestication events, and provides a framework for genotype–phenotype studies in this model organism.

    • Jackson Peter
    • , Matteo De Chiara
    • , Anne Friedrich
    • , Jia-Xing Yue
    • , David Pflieger
    • , Anders Bergström
    • , Anastasie Sigwalt
    • , Benjamin Barre
    • , Kelle Freel
    • , Agnès Llored
    • , Corinne Cruaud
    • , Karine Labadie
    • , Jean-Marc Aury
    • , Benjamin Istace
    • , Kevin Lebrigand
    • , Pascal Barbry
    • , Stefan Engelen
    • , Arnaud Lemainque
    • , Patrick Wincker
    • , Gianni Liti
    •  & Joseph Schacherer
  • Article |

    Organoids derived from individual cells from colorectal cancers and adjacent normal tissue are used to investigate intra-tumour diversification at the genomic, epigenetic and functional levels.

    • Sophie F. Roerink
    • , Nobuo Sasaki
    • , Henry Lee-Six
    • , Matthew D. Young
    • , Ludmil B. Alexandrov
    • , Sam Behjati
    • , Thomas J. Mitchell
    • , Sebastian Grossmann
    • , Howard Lightfoot
    • , David A. Egan
    • , Apollo Pronk
    • , Niels Smakman
    • , Joost van Gorp
    • , Elizabeth Anderson
    • , Stephen J. Gamble
    • , Chris Alder
    • , Marc van de Wetering
    • , Peter J. Campbell
    • , Michael R. Stratton
    •  & Hans Clevers
  • Article |

    Galanin-expressing neurons in the medial preoptic area coordinate different aspects of motor, motivational, hormonal and social behaviour associated with parenting by projecting to different brain regions depending on the type of behaviour and sex and reproductive state of mice.

    • Johannes Kohl
    • , Benedicte M. Babayan
    • , Nimrod D. Rubinstein
    • , Anita E. Autry
    • , Brenda Marin-Rodriguez
    • , Vikrant Kapoor
    • , Kazunari Miyamishi
    • , Larry S. Zweifel
    • , Liqun Luo
    • , Naoshige Uchida
    •  & Catherine Dulac