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  • A couple-close approach used to build semisaturated ring systems from dual radical precursors allows sampling of regions of underexplored chemical space, leading to an annulation that can be used for late-stage functionalization of pharmaceutical scaffolds.

    • Alice Long
    • Christian J. Oswood
    • David W. C. MacMillan
    Article
  • The hippocampal dentate spike, an understudied population event that frequently occurs between sharp-wave ripples, may underlie a mechanism re-engaging the brain with the external world during synchronous population events, and support memory during non-locomotor behaviour.

    • Jordan S. Farrell
    • Ernie Hwaun
    • Ivan Soltesz
    ArticleOpen Access
  • Combining single-cell RNA-sequencing with high-resolution multiplexed error-robust fluorescence in situ hybridization reveals in detail the cellular interactions and specialization of cardiac cell types that form and remodel the human heart.

    • Elie N. Farah
    • Robert K. Hu
    • Neil C. Chi
    ArticleOpen Access
  • High-density, intrinsically stretchable transistors with high driving ability and integrated circuits with high operation speed and large-scale integration were enabled by a combination of innovations in materials, fabrication process design, device engineering and circuit design.

    • Donglai Zhong
    • Can Wu
    • Zhenan Bao
    Article
  • By examining the hourly diurnal cycle of 23,557 fires in North America during 2017–2020, 1,095 overnight burning events were identified, mostly associated with extreme fires and driven by long-term drought conditions.

    • Kaiwei Luo
    • Xianli Wang
    • Mike Flannigan
    Article
  • Time-resolved cryo-EM is used to capture structural transitions during G-protein activation stimulated by a G-protein-coupled receptor.

    • Makaía M. Papasergi-Scott
    • Guillermo Pérez-Hernández
    • Georgios Skiniotis
    Article
  • A cluster randomized controlled trial in Sierra Leone shows that targeting access to vaccines in remote areas increases uptake, an approach that can be used to improve vaccine equity in developing countries.

    • Niccolò F. Meriggi
    • Maarten Voors
    • Ahmed Mushfiq Mobarak
    ArticleOpen Access
  • We introduce a scalable, high-resolution, 3D printing technique for the fabrication of shape-specific particles based on roll-to-roll continuous liquid interface production, enabling direct integration within biomedical, analytical and advanced materials applications.

    • Jason M. Kronenfeld
    • Lukas Rother
    • Joseph M. DeSimone
    ArticleOpen Access
  • We uncover key processes of the genomic evolution of small cell lung cancer under therapy, identify the common ancestor as the source of clonal diversity at relapse and show central genomic patterns associated with drug response.

    • Julie George
    • Lukas Maas
    • Roman K. Thomas
    ArticleOpen Access
  • A micro-fabricated Penning trap that operates at a 3 T magnetic field demonstrates full quantum control of an ion and the ability to transport the ion arbitrarily in the trapping plane above the chip.

    • Shreyans Jain
    • Tobias Sägesser
    • Jonathan Home
    ArticleOpen Access
  • A global high-resolution disaster footprint analytical model is developed to show substantial socioeconomic impacts from climatic change-driven heat stress through the global supply chain by 2060 due to direct and indirect effects on health and labour productivity.

    • Yida Sun
    • Shupeng Zhu
    • Dabo Guan
    ArticleOpen Access
  • A comparative analysis tests competing evolutionary hypotheses in toothed whales in which menopause has evolved many times as females extended their overall lifespan but not their reproductive lifespan, increasing their opportunity for intergenerational help without increasing intergenerational reproductive competition.

    • Samuel Ellis
    • Daniel W. Franks
    • Darren P. Croft
    ArticleOpen Access