Analyses

  • Analysis |

    Climate has affected organized armed conflict within countries, and intensifying climate change is estimated to increase future risks of conflict, although other drivers are substantially more influential and the mechanisms of climate–conflict linkages remain uncertain.

    • Katharine J. Mach
    • , Caroline M. Kraan
    • , W. Neil Adger
    • , Halvard Buhaug
    • , Marshall Burke
    • , James D. Fearon
    • , Christopher B. Field
    • , Cullen S. Hendrix
    • , Jean-Francois Maystadt
    • , John O’Loughlin
    • , Philip Roessler
    • , Jürgen Scheffran
    • , Kenneth A. Schultz
    •  & Nina von Uexkull
  • Analysis |

    The characterization of missense histone mutations that occur across several cancer types provides insight into the potential role of these mutations in altering chromatin structure and potentially contributing to tumour development.

    • Benjamin A. Nacev
    • , Lijuan Feng
    • , John D. Bagert
    • , Agata E. Lemiesz
    • , JianJiong Gao
    • , Alexey A. Soshnev
    • , Ritika Kundra
    • , Nikolaus Schultz
    • , Tom W. Muir
    •  & C. David Allis
  • Analysis |

    • Andrew Shepherd
    • , Erik Ivins
    • , Eric Rignot
    • , Ben Smith
    • , Michiel van den Broeke
    • , Isabella Velicogna
    • , Pippa Whitehouse
    • , Kate Briggs
    • , Ian Joughin
    • , Gerhard Krinner
    • , Sophie Nowicki
    • , Tony Payne
    • , Ted Scambos
    • , Nicole Schlegel
    • , Geruo A
    • , Cécile Agosta
    • , Andreas Ahlstrøm
    • , Greg Babonis
    • , Valentina Barletta
    • , Alejandro Blazquez
    • , Jennifer Bonin
    • , Beata Csatho
    • , Richard Cullather
    • , Denis Felikson
    • , Xavier Fettweis
    • , Rene Forsberg
    • , Hubert Gallee
    • , Alex Gardner
    • , Lin Gilbert
    • , Andreas Groh
    • , Brian Gunter
    • , Edward Hanna
    • , Christopher Harig
    • , Veit Helm
    • , Alexander Horvath
    • , Martin Horwath
    • , Shfaqat Khan
    • , Kristian K. Kjeldsen
    • , Hannes Konrad
    • , Peter Langen
    • , Benoit Lecavalier
    • , Bryant Loomis
    • , Scott Luthcke
    • , Malcolm McMillan
    • , Daniele Melini
    • , Sebastian Mernild
    • , Yara Mohajerani
    • , Philip Moore
    • , Jeremie Mouginot
    • , Gorka Moyano
    • , Alan Muir
    • , Thomas Nagler
    • , Grace Nield
    • , Johan Nilsson
    • , Brice Noel
    • , Ines Otosaka
    • , Mark E. Pattle
    • , W. Richard Peltier
    • , Nadege Pie
    • , Roelof Rietbroek
    • , Helmut Rott
    • , Louise Sandberg-Sørensen
    • , Ingo Sasgen
    • , Himanshu Save
    • , Bernd Scheuchl
    • , Ernst Schrama
    • , Ludwig Schröder
    • , Ki-Weon Seo
    • , Sebastian Simonsen
    • , Tom Slater
    • , Giorgio Spada
    • , Tyler Sutterley
    • , Matthieu Talpe
    • , Lev Tarasov
    • , Willem Jan van de Berg
    • , Wouter van der Wal
    • , Melchior van Wessem
    • , Bramha Dutt Vishwakarma
    • , David Wiese
    •  & Bert Wouters
  • Analysis |

    Analysis of 2002–2016 GRACE satellite observations of terrestrial water storage reveals substantial changes in freshwater resources globally, which are driven by natural and anthropogenic climate variability and human activities.

    • M. Rodell
    • , J. S. Famiglietti
    • , D. N. Wiese
    • , J. T. Reager
    • , H. K. Beaudoing
    • , F. W. Landerer
    •  & M.-H. Lo
  • Analysis
    | Open Access

    Investing in adolescents as the parents of the next generation is important for the wellbeing of current and future generations.

    • George C. Patton
    • , Craig A. Olsson
    • , Vegard Skirbekk
    • , Richard Saffery
    • , Mary E. Wlodek
    • , Peter S. Azzopardi
    • , Marcin Stonawski
    • , Bruce Rasmussen
    • , Elizabeth Spry
    • , Kate Francis
    • , Zulfiqar A. Bhutta
    • , Nicholas J. Kassebaum
    • , Ali H. Mokdad
    • , Christopher J. L. Murray
    • , Andrew M. Prentice
    • , Nicola Reavley
    • , Peter Sheehan
    • , Kim Sweeny
    • , Russell M. Viner
    •  & Susan M. Sawyer
  • Analysis |

    The large number of small, similarly sized proteins and the small number of heavy RNA molecules that make up a ribosome reduce the time required for reproduction.

    • Shlomi Reuveni
    • , Måns Ehrenberg
    •  & Johan Paulsson
  • Analysis |

    Apparently contradictory conclusions regarding the ‘global warming hiatus’ are reconciled, strengthening the current scientific understanding that long-term global warming is extremely likely to be of anthropogenic origin.

    • Iselin Medhaug
    • , Martin B. Stolpe
    • , Erich M. Fischer
    •  & Reto Knutti
  • Analysis |

    Large-scale analyses of the drug sensitivity of cancer cell lines have been previously reported to yield conflicting conclusions; this Analysis uses independently generated data to demonstrate that consistency can be achieved if key laboratory and data analysis practices are considered when future studies are undertaken.

    • Peter M. Haverty
    • , Eva Lin
    • , Jenille Tan
    • , Yihong Yu
    • , Billy Lam
    • , Steve Lianoglou
    • , Richard M. Neve
    • , Scott Martin
    • , Jeff Settleman
    • , Robert L. Yauch
    •  & Richard Bourgon
  • Analysis |

    In panels of cancer cell lines analysed for their response to drug libraries, some studies have proposed distinct pharmacological sensitivities for some cell lines while other studies have not seen the same trends; here the data in the Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer are reassessed, and the authors report a stronger degree of concordance between the two data sets than that in a previous study.

    • The Cancer Cell Line Encyclopedia Consortium
    •  & The Genomics of Drug Sensitivity in Cancer Consortium
  • Analysis |

    There are 800 human GPCRs and 16 different Gα proteins; this study revealed the molecular details of Gα activation by GPCRs and suggests that a universal activation mechanism governs Gα activation—the details of this mechanism can explain how the GPCR–Gα system diversified rapidly, while conserving the allosteric activation mechanism.

    • Tilman Flock
    • , Charles N. J. Ravarani
    • , Dawei Sun
    • , A. J. Venkatakrishnan
    • , Melis Kayikci
    • , Christopher G. Tate
    • , Dmitry B. Veprintsev
    •  & M. Madan Babu
  • Analysis |

    It has been long known that many cultured cell lines, an essential tool not only in biological research but also other areas of science, are contaminated, mislabelled or incorrectly annotated; here an analysis covering over 3,500 cell lines and their unambiguous authentication and annotation offers the community a reference point for both STR and SNP profiles as genetic methods of cell authentication, combined with suggested standards for nomenclature using a controlled vocabulary.

    • Mamie Yu
    • , Suresh K. Selvaraj
    • , May M. Y. Liang-Chu
    • , Sahar Aghajani
    • , Matthew Busse
    • , Jean Yuan
    • , Genee Lee
    • , Franklin Peale
    • , Christiaan Klijn
    • , Richard Bourgon
    • , Joshua S. Kaminker
    •  & Richard M. Neve
  • Analysis |

    Data on Vesta’s surface material provided by the Dawn probe and impacts modelling reveals that Vesta’s crust–mantle boundary must be deeper than 80 kilometres below the surface.

    • Harold Clenet
    • , Martin Jutzi
    • , Jean-Alix Barrat
    • , Erik I. Asphaug
    • , Willy Benz
    •  & Philippe Gillet
  • Analysis |

    This Analysis compares two large-scale pharmacogenomic data sets that catalogued the sensitivity of a large number of cancer cell lines to approved and potential drugs, and finds that whereas the gene expression data are largely concordant between the two studies, the reported drug sensitivity measures and subsequently their association with genomic features are highly discordant.

    • Benjamin Haibe-Kains
    • , Nehme El-Hachem
    • , Nicolai Juul Birkbak
    • , Andrew C. Jin
    • , Andrew H. Beck
    • , Hugo J. W. L. Aerts
    •  & John Quackenbush
  • Analysis |

    Building a device capable of factoring large numbers is a major goal of quantum computing; an algorithm for quantum factoring (Shor’s algorithm) exists, and a simple coin-tossing exercise is used to illustrate the dangers of oversimplification when implementing this algorithm experimentally.

    • John A. Smolin
    • , Graeme Smith
    •  & Alexander Vargo
  • Analysis |

    • Jonathan A. Foley
    • , Navin Ramankutty
    • , Kate A. Brauman
    • , Emily S. Cassidy
    • , James S. Gerber
    • , Matt Johnston
    • , Nathaniel D. Mueller
    • , Christine O’Connell
    • , Deepak K. Ray
    • , Paul C. West
    • , Christian Balzer
    • , Elena M. Bennett
    • , Stephen R. Carpenter
    • , Jason Hill
    • , Chad Monfreda
    • , Stephen Polasky
    • , Johan Rockström
    • , John Sheehan
    • , Stefan Siebert
    • , David Tilman
    •  & David P. M. Zaks
  • Analysis |

    The strength of network biology lies in its ability to derive cell biological information without a priori mechanistic or molecular knowledge. It is demonstrated that a molecular understanding of clathrin-mediated endocytosis can refine the network approach and allows the derivation of general biological principles.

    • Eva M. Schmid
    •  & Harvey T. McMahon
  • Analysis |

    • Jeremy Schmutz
    • , Jeremy Wheeler
    • , Jane Grimwood
    • , Mark Dickson
    • , Joan Yang
    • , Chenier Caoile
    • , Eva Bajorek
    • , Stacey Black
    • , Yee Man Chan
    • , Mirian Denys
    • , Julio Escobar
    • , Dave Flowers
    • , Dea Fotopulos
    • , Carmen Garcia
    • , Maria Gomez
    • , Eidelyn Gonzales
    • , Lauren Haydu
    • , Frederick Lopez
    • , Lucia Ramirez
    • , James Retterer
    • , Alex Rodriguez
    • , Stephanie Rogers
    • , Angelica Salazar
    • , Ming Tsai
    •  & Richard M. Myers
  • Analysis |

    • P. Andrew Futreal
    • , Arek Kasprzyk
    • , Ewan Birney
    • , James C. Mullikin
    • , Richard Wooster
    •  & Michael R. Stratton
  • Analysis |

    • Gerardo Jimenez-Sanchez
    • , Barton Childs
    •  & David Valle
  • Analysis |

    • Aude M. Fahrer
    • , J. Fernando Bazan
    • , Peter Papathanasiou
    • , Keats A. Nelms
    •  & Christopher C. Goodnow
  • Analysis |

    Closer integration between European research and the needs of society would have a positive effect on the development of Europe while helping to shape the future of its scientific communities. To promote those aims we intend to create 'Euroscience', an open association of all those interested in science and its consequences on society.

    • Françoise Praderie