Browse Articles

  • Article |

    In Saccharomyces cerevisiae, Ubx2 promotes clearing trapped precursor proteins from the channel of the translocase of the outer membrane, in a translocation-associated degradation pathway that maintains the protein import capacity of mitochondria.

    • Christoph U. Mårtensson
    • , Chantal Priesnitz
    • , Jiyao Song
    • , Lars Ellenrieder
    • , Kim Nguyen Doan
    • , Felix Boos
    • , Alessia Floerchinger
    • , Nicole Zufall
    • , Silke Oeljeklaus
    • , Bettina Warscheid
    •  & Thomas Becker
  • Nature Briefing |

    With abortion bans going on the books in US states, what does the research say? Plus: an influential panel has voted to officially name the Anthropocene epoch and science in Europe on the eve of the European Union’s parliamentary elections.

    • Flora Graham
  • News Feature |

    On the eve of the European Union’s parliamentary elections, a special issue examines the prospects for science across the region.

  • Letter |

    Emissions from eastern China account for approximately 40 to 60 per cent of the global rise in emissions of trichlorofluoromethane (CFC-11), which may be a result of new production and use.

    • M. Rigby
    • , S. Park
    • , T. Saito
    • , L. M. Western
    • , A. L. Redington
    • , X. Fang
    • , S. Henne
    • , A. J. Manning
    • , R. G. Prinn
    • , G. S. Dutton
    • , P. J. Fraser
    • , A. L. Ganesan
    • , B. D. Hall
    • , C. M. Harth
    • , J. Kim
    • , K.-R. Kim
    • , P. B. Krummel
    • , T. Lee
    • , S. Li
    • , Q. Liang
    • , M. F. Lunt
    • , S. A. Montzka
    • , J. Mühle
    • , S. O’Doherty
    • , M.-K. Park
    • , S. Reimann
    • , P. K. Salameh
    • , P. Simmonds
    • , R. L. Tunnicliffe
    • , R. F. Weiss
    • , Y. Yokouchi
    •  & D. Young
  • Letter |

    • Suzanne Z. Andersen
    • , Viktor Čolić
    • , Sungeun Yang
    • , Jay A. Schwalbe
    • , Adam C. Nielander
    • , Joshua M. McEnaney
    • , Kasper Enemark-Rasmussen
    • , Jon G. Baker
    • , Aayush R. Singh
    • , Brian A. Rohr
    • , Michael J. Statt
    • , Sarah J. Blair
    • , Stefano Mezzavilla
    • , Jakob Kibsgaard
    • , Peter C. K. Vesborg
    • , Matteo Cargnello
    • , Stacey F. Bent
    • , Thomas F. Jaramillo
    • , Ifan E. L. Stephens
    • , Jens K. Nørskov
    •  & Ib Chorkendorff
  • News & Views |

    For a century, researchers have sought materials that superconduct — transport electricity without loss — at room temperature. Experimental data now confirm superconductivity at higher temperatures than ever before.

    • James J. Hamlin
  • News & Views |

    The protein-import systems of organelles can become clogged by proteins. A protein from one organelle, the endoplasmic reticulum, is found to also unclog such blockages in mitochondrial organelles.

    • Sylvie Callegari
    •  & Peter Rehling
  • Letter |

    A lanthanum hydride compound at a pressure of around 170 gigapascals is found to exhibit superconductivity with a critical temperature of 250 kelvin.

    • A. P. Drozdov
    • , P. P. Kong
    • , V. S. Minkov
    • , S. P. Besedin
    • , M. A. Kuzovnikov
    • , S. Mozaffari
    • , L. Balicas
    • , F. F. Balakirev
    • , D. E. Graf
    • , V. B. Prakapenka
    • , E. Greenberg
    • , D. A. Knyazev
    • , M. Tkacz
    •  & M. I. Eremets
  • Letter |

    Slow compression of ice at low temperature results in the sequential formation of a series of crystalline phases, challenging theories that connect amorphous ice to supercooled liquid water.

    • Chris A. Tulk
    • , Jamie J. Molaison
    • , Adam R. Makhluf
    • , Craig E. Manning
    •  & Dennis D. Klug
  • News Feature |

    The region already hosts some of the world’s leading scientific countries, and some of its smaller states are quickly catching up.

    • Richard Van Noorden
    •  & Declan Butler
  • Letter |

    A molecular model of STING-mediated signalling is proposed, as structural analysis identifies a crucial motif for the binding of TBK1 to STING, and a separate model involved in IRF-3 binding.

    • Baoyu Zhao
    • , Fenglei Du
    • , Pengbiao Xu
    • , Chang Shu
    • , Banumathi Sankaran
    • , Samantha L. Bell
    • , Mengmeng Liu
    • , Yuanjiu Lei
    • , Xinsheng Gao
    • , Xiaofeng Fu
    • , Fanxiu Zhu
    • , Yang Liu
    • , Arthur Laganowsky
    • , Xueyun Zheng
    • , Jun-Yuan Ji
    • , A. Phillip West
    • , Robert O. Watson
    •  & Pingwei Li
  • Letter |

    Seafloor-derived planktonic foraminifera communities of pre-industrial age are compared with communities from sediment-trap time series and show that Anthropocene communities of a globally distributed zooplankton group differ from their unperturbed pre-industrial state.

    • Lukas Jonkers
    • , Helmut Hillebrand
    •  & Michal Kucera
  • News & Views |

    A classic study found that crystalline ice adopts an amorphous form when compressed. Experiments now find that alternative phase transitions can occur — with implications for theories about water’s structure.

    • John S. Tse
  • Article |

    The dopamine projection from midbrain dopamine cells to the nucleus accumbens is essential for normal motivation, yet motivation-related changes in nucleus accumbens dopamine release occur independently of dopamine cell firing.

    • Ali Mohebi
    • , Jeffrey R. Pettibone
    • , Arif A. Hamid
    • , Jenny-Marie T. Wong
    • , Leah T. Vinson
    • , Tommaso Patriarchi
    • , Lin Tian
    • , Robert T. Kennedy
    •  & Joshua D. Berke
  • Letter |

    Patient data from six clinical trials are used to compare the genomic landscapes of breast cancer metastases with those of primary tumours, revealing an increase in mutational burden and clonal diversity.

    • François Bertucci
    • , Charlotte K. Y. Ng
    • , Anne Patsouris
    • , Nathalie Droin
    • , Salvatore Piscuoglio
    • , Nadine Carbuccia
    • , Jean Charles Soria
    • , Alicia Tran Dien
    • , Yahia Adnani
    • , Maud Kamal
    • , Séverine Garnier
    • , Guillaume Meurice
    • , Marta Jimenez
    • , Semih Dogan
    • , Benjamin Verret
    • , Max Chaffanet
    • , Thomas Bachelot
    • , Mario Campone
    • , Claudia Lefeuvre
    • , Herve Bonnefoi
    • , Florence Dalenc
    • , Alexandra Jacquet
    • , Maria R. De Filippo
    • , Naveen Babbar
    • , Daniel Birnbaum
    • , Thomas Filleron
    • , Christophe Le Tourneau
    •  & Fabrice André
  • Letter |

    Observations that molecular gas in NGC 300 is spatially uncorrelated with high-mass stars are attributed to rapid evolution, with molecular clouds quickly destroyed by stellar feedback, and low star-formation efficiency.

    • J. M. Diederik Kruijssen
    • , Andreas Schruba
    • , Mélanie Chevance
    • , Steven N. Longmore
    • , Alexander P. S. Hygate
    • , Daniel T. Haydon
    • , Anna F. McLeod
    • , Julianne J. Dalcanton
    • , Linda J. Tacconi
    •  & Ewine F. van Dishoeck
  • Letter |

    Spatial genome organization into lamina-associated domains is first established in the mouse zygote immediately after fertilization without inheritance from the maternal germline—with the paternal and maternal pronucleus exhibiting different organization, which subsequently converges prior to implantation of the embryo.

    • Máté Borsos
    • , Sara M. Perricone
    • , Tamás Schauer
    • , Julien Pontabry
    • , Kim L. de Luca
    • , Sandra S. de Vries
    • , Elias R. Ruiz-Morales
    • , Maria-Elena Torres-Padilla
    •  & Jop Kind
  • News & Views |

    The neurotransmitter dopamine facilitates learning, motivation and movement. Evidence of its release independently of the activity of dopamine-producing neurons in rat brains forces a rethink of dopamine regulation.

    • Margaret E. Rice
  • Letter |

    The stability of both colloidal quantum dots and perovskites can be improved by combining them into a hybrid material in which matched lattice parameters suppress the formation of undesired phases.

    • Mengxia Liu
    • , Yuelang Chen
    • , Chih-Shan Tan
    • , Rafael Quintero-Bermudez
    • , Andrew H. Proppe
    • , Rahim Munir
    • , Hairen Tan
    • , Oleksandr Voznyy
    • , Benjamin Scheffel
    • , Grant Walters
    • , Andrew Pak Tao Kam
    • , Bin Sun
    • , Min-Jae Choi
    • , Sjoerd Hoogland
    • , Aram Amassian
    • , Shana O. Kelley
    • , F. Pelayo García de Arquer
    •  & Edward H. Sargent
  • Letter |

    The epitaxial growth of large single-crystal hexagonal boron nitride monolayers on low-symmetry copper foils is demonstrated.

    • Li Wang
    • , Xiaozhi Xu
    • , Leining Zhang
    • , Ruixi Qiao
    • , Muhong Wu
    • , Zhichang Wang
    • , Shuai Zhang
    • , Jing Liang
    • , Zhihong Zhang
    • , Zhibin Zhang
    • , Wang Chen
    • , Xuedong Xie
    • , Junyu Zong
    • , Yuwei Shan
    • , Yi Guo
    • , Marc Willinger
    • , Hui Wu
    • , Qunyang Li
    • , Wenlong Wang
    • , Peng Gao
    • , Shiwei Wu
    • , Yi Zhang
    • , Ying Jiang
    • , Dapeng Yu
    • , Enge Wang
    • , Xuedong Bai
    • , Zhu-Jun Wang
    • , Feng Ding
    •  & Kaihui Liu
  • Letter |

    Morphological, ultrastructural and spectroscopic analyses identify a fungal affinity for microfossils in shale from Arctic Canada, which pushes back the date for this kingdom to 1,010–890 million years ago.

    • Corentin C. Loron
    • , Camille François
    • , Robert H. Rainbird
    • , Elizabeth C. Turner
    • , Stephan Borensztajn
    •  & Emmanuelle J. Javaux
  • Article | | open

    Exome-sequencing analyses of a large cohort of patients with type 2 diabetes and control individuals without diabetes from five ancestries are used to identify gene-level associations of rare variants that are associated with type 2 diabetes.

    • Jason Flannick
    • , Josep M. Mercader
    • , Christian Fuchsberger
    • , Miriam S. Udler
    • , Anubha Mahajan
    • , Jennifer Wessel
    • , Tanya M. Teslovich
    • , Lizz Caulkins
    • , Ryan Koesterer
    • , Francisco Barajas-Olmos
    • , Thomas W. Blackwell
    • , Eric Boerwinkle
    • , Jennifer A. Brody
    • , Federico Centeno-Cruz
    • , Ling Chen
    • , Siying Chen
    • , Cecilia Contreras-Cubas
    • , Emilio Córdova
    • , Adolfo Correa
    • , Maria Cortes
    • , Ralph A. DeFronzo
    • , Lawrence Dolan
    • , Kimberly L. Drews
    • , Amanda Elliott
    • , James S. Floyd
    • , Stacey Gabriel
    • , Maria Eugenia Garay-Sevilla
    • , Humberto García-Ortiz
    • , Myron Gross
    • , Sohee Han
    • , Nancy L. Heard-Costa
    • , Anne U. Jackson
    • , Marit E. Jørgensen
    • , Hyun Min Kang
    • , Megan Kelsey
    • , Bong-Jo Kim
    • , Heikki A. Koistinen
    • , Johanna Kuusisto
    • , Joseph B. Leader
    • , Allan Linneberg
    • , Ching-Ti Liu
    • , Jianjun Liu
    • , Valeriya Lyssenko
    • , Alisa K. Manning
    • , Anthony Marcketta
    • , Juan Manuel Malacara-Hernandez
    • , Angélica Martínez-Hernández
    • , Karen Matsuo
    • , Elizabeth Mayer-Davis
    • , Elvia Mendoza-Caamal
    • , Karen L. Mohlke
    • , Alanna C. Morrison
    • , Anne Ndungu
    • , Maggie C. Y. Ng
    • , Colm O’Dushlaine
    • , Anthony J. Payne
    • , Catherine Pihoker
    • , Wendy S. Post
    • , Michael Preuss
    • , Bruce M. Psaty
    • , Ramachandran S. Vasan
    • , N. William Rayner
    • , Alexander P. Reiner
    • , Cristina Revilla-Monsalve
    • , Neil R. Robertson
    • , Nicola Santoro
    • , Claudia Schurmann
    • , Wing Yee So
    • , Xavier Soberón
    • , Heather M. Stringham
    • , Tim M. Strom
    • , Claudia H. T. Tam
    • , Farook Thameem
    • , Brian Tomlinson
    • , Jason M. Torres
    • , Russell P. Tracy
    • , Rob M. van Dam
    • , Marijana Vujkovic
    • , Shuai Wang
    • , Ryan P. Welch
    • , Daniel R. Witte
    • , Tien-Yin Wong
    • , Gil Atzmon
    • , Nir Barzilai
    • , John Blangero
    • , Lori L. Bonnycastle
    • , Donald W. Bowden
    • , John C. Chambers
    • , Edmund Chan
    • , Ching-Yu Cheng
    • , Yoon Shin Cho
    • , Francis S. Collins
    • , Paul S. de Vries
    • , Ravindranath Duggirala
    • , Benjamin Glaser
    • , Clicerio Gonzalez
    • , Ma Elena Gonzalez
    • , Leif Groop
    • , Jaspal Singh Kooner
    • , Soo Heon Kwak
    • , Markku Laakso
    • , Donna M. Lehman
    • , Peter Nilsson
    • , Timothy D. Spector
    • , E. Shyong Tai
    • , Tiinamaija Tuomi
    • , Jaakko Tuomilehto
    • , James G. Wilson
    • , Carlos A. Aguilar-Salinas
    • , Erwin Bottinger
    • , Brian Burke
    • , David J. Carey
    • , Juliana C. N. Chan
    • , Josée Dupuis
    • , Philippe Frossard
    • , Susan R. Heckbert
    • , Mi Yeong Hwang
    • , Young Jin Kim
    • , H. Lester Kirchner
    • , Jong-Young Lee
    • , Juyoung Lee
    • , Ruth J. F. Loos
    • , Ronald C. W. Ma
    • , Andrew D. Morris
    • , Christopher J. O’Donnell
    • , Colin N. A. Palmer
    • , James Pankow
    • , Kyong Soo Park
    • , Asif Rasheed
    • , Danish Saleheen
    • , Xueling Sim
    • , Kerrin S. Small
    • , Yik Ying Teo
    • , Christopher Haiman
    • , Craig L. Hanis
    • , Brian E. Henderson
    • , Lorena Orozco
    • , Teresa Tusié-Luna
    • , Frederick E. Dewey
    • , Aris Baras
    • , Christian Gieger
    • , Thomas Meitinger
    • , Konstantin Strauch
    • , Leslie Lange
    • , Niels Grarup
    • , Torben Hansen
    • , Oluf Pedersen
    • , Philip Zeitler
    • , Dana Dabelea
    • , Goncalo Abecasis
    • , Graeme I. Bell
    • , Nancy J. Cox
    • , Mark Seielstad
    • , Rob Sladek
    • , James B. Meigs
    • , Steve S. Rich
    • , Jerome I. Rotter
    • , David Altshuler
    • , Noël P. Burtt
    • , Laura J. Scott
    • , Andrew P. Morris
    • , Jose C. Florez
    • , Mark I. McCarthy
    •  & Michael Boehnke
  • Comment |

    Nature asked nine leading Europeans to pick their top priority for science at this pivotal point. Love, money, and trust got most votes.

    • Carlos Moedas
    • , Isabelle Vernos
    • , Stephan Kuster
    • , Helga Nowotny
    • , Andrea Saltelli
    • , Alina Mungiu-Pippidi
    • , Jan Wouter Vasbinder
    • , Daniel R. Brooks
    •  & Patrick Cunningham
  • Career Column |

    It’s tempting to try to attend sessions morning, noon and night, network like crazy during every ‘spare’ minute and drink vats of coffee to stay alert. Paris H. Grey has more realistic suggestions to get maximum value from any conference.

    • Paris H. Grey
  • Comment |

    Proactive, cosmopolitan and open, the European Union is filling a leadership void on the global stage, argue James Wilsdon and Sarah de Rijcke.

    • James Wilsdon
    •  & Sarah de Rijcke