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The effect of vitamin C deprivation on mouse germline development is analysed, revealing that maternal vitamin C is required for proper DNA demethylation and the development of fetal oocytes, whereas the lack of vitamin C during pregnancy leads to reduced female fecundity in the offspring.
The cellular degradative machinery can be asymmetrically inherited upon haematopoietic-stem-cell division, which predicts the future metabolic and translational activation of their daughter cells.
H3K36me2 targets DNMT3A to intergenic regions and this process, together with H3K36me3-mediated recruitment of DNMT3B, has a key role in establishing and maintaining genomic DNA methylation landscapes.
Comparisons between past regional drivers of precipitation extremes found time series data from Lake Ohrid and modern climate models of the Mediterranean may help to reduce simulation uncertainties in predictions of the Mediterranean climate.
Using phreatic overgrowths on speleothems, sea level during the mid-Piacenzian Warm Period, which was about two to three degrees Celsius warmer than the pre-industrial period, is shown to have been about 16 metres higher than today.
Superconductivity is demonstrated in an infinite-layer nickelate similar to infinite-layer copper oxides, which is synthesized using soft- chemistry topotactic reduction of the perovskite precursor phase.
Molecular analysis and mathematical modelling are combined to identify a network of factors that account for viscoplastic deformation in elongation of Caenorhabditis elegans during embryonic development.
The predicted increase in frequency of droughts and rising temperatures in Europe will lead core populations of a temperate plant to an evolutionary dead-end unless they acquire genetic alleles that are present only in extreme edge Mediterranean, Scandinavian, or Siberian populations.
Tissue rheology emerges from the interplay between fibrous networks and cell inclusions, and the mechanical properties of tissues are modulated by restricting the relaxation modes of fibres close to volume-conserving cells.
The limitations of conventional chemical doping of polymeric semiconductors can be overcome by adding a second ionic species into the system, leading to enhanced doping, electrical conductivity and stability.
The structure of a mammalian proton-translocating transhydrogenase in various conformations is solved by cryo-electron microscopy, and a mechanism for the coupling process within the enzyme is proposed.
The release of tyramine during the flight response in nematodes activates the DAF-2/insulin–IGF pathway to downregulate cytoprotective mechanisms and shorten lifespan.
The palmitoylation of STAT3 is mediated by fatty acids and/or the palmitoyl acyltransferase ZDHHC19, and deregulation of this palmitoylation has a role in inflammation and tumorigenesis.
Analysis of a comprehensive European flood dataset reveals regional changes in river flood discharges in the past five decades that are consistent with models suggesting that climate-driven changes are already happening.
The dynamics of interactions between hate-orientated networks on different online platforms is characterized, and a mathematical model predicts that policing on one online platform can make matters worse and generate ‘darker’ parts of the Internet.
Soil radiocarbon dating reveals that combusted ‘legacy carbon’—soil carbon that escaped burning during previous fires—could shift the carbon balance of boreal ecosystems, resulting in a positive climate feedback.
Titration gas chromatography is developed as an analytical method of distinguishing between lithium metal and lithium compounds within a cycled battery and assessing the amount of unreacted metallic lithium available.
The gut commensal Blautia producta secretes a lantibiotic that reduces colonization of the gut by the major pathogen vancomycin-resistant Enterococcus faecium, and transplantation of microbiota with high abundance of the lantibiotic gene enhances resistance to colonization in mice.
A method of droplet manipulation is described that uses electrical signals to induce the liquid to dewet, rather than wet, a hydrophilic conductive surface.
RNA-dependent DEAD-box ATPases (DDXs) regulate the dynamics of phase-separated organelles, with ATP-bound DDXs promoting phase separation, and ATP hydrolysis inducing compartment disassembly and RNA release.