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In a mouse model of enteric pathogen infection, tryptophan metabolites protect against infection via activation of dopamine receptor D2 and regulation of actin cytoskeletal organization in intestinal epithelial cells.
Blocking mitochondrial complex I in pro-inflammatory microglia protects the central nervous system against neurotoxic damage and improves functional outcomes in vivo in an animal disease model.
A cluster randomized controlled trial in Sierra Leone shows that targeting access to vaccines in remote areas increases uptake, an approach that can be used to improve vaccine equity in developing countries.
We introduce a scalable, high-resolution, 3D printing technique for the fabrication of shape-specific particles based on roll-to-roll continuous liquid interface production, enabling direct integration within biomedical, analytical and advanced materials applications.
Macrophages are revealed to adopt a polymerase II pause/release process to effectively deal with ingested apoptotic corpses and for continuous efferocytosis.
We uncover key processes of the genomic evolution of small cell lung cancer under therapy, identify the common ancestor as the source of clonal diversity at relapse and show central genomic patterns associated with drug response.
A micro-fabricated Penning trap that operates at a 3 T magnetic field demonstrates full quantum control of an ion and the ability to transport the ion arbitrarily in the trapping plane above the chip.
A global high-resolution disaster footprint analytical model is developed to show substantial socioeconomic impacts from climatic change-driven heat stress through the global supply chain by 2060 due to direct and indirect effects on health and labour productivity.
A comparative analysis tests competing evolutionary hypotheses in toothed whales in which menopause has evolved many times as females extended their overall lifespan but not their reproductive lifespan, increasing their opportunity for intergenerational help without increasing intergenerational reproductive competition.
Single-neuron and population activity in the macaque prefrontal and temporal cortex robustly encodes 24 species-typical behaviours, reciprocity in social interactions and social support.
We demonstrate that self-enhanced mobility offers a simple physical mechanism for pattern formation in living systems and, more generally, in other active matter systems near the boundary of fluid- and solid-like behaviours.
Cultivation of a new anoxygenic phototrophic bacterium from Boreal Shield lake water—representing a transition form in the evolution of photosynthesis—offers insights into how the major modes of phototrophy diversified.
A microglial state, featuring lipid droplets and secretion of neurotoxic factors, is shown to be most prominent in people with Alzheimer’s disease who have the APOE4 genotype.
We demonstrate an all-optical, mode-locking, Kerr-comb frequency division method that provides a chip-scale microwave source that is extremely versatile, accurate, stable and has ultralow noise, using only a single continuous-wave laser.
A miniaturized optical frequency division system that could transfer the generation of microwaves, with superior spectral purity, to a complementary metal-oxide-semiconductor-compatible integrated photonic platform is demonstrated showing potential for large-volume, low-cost manufacturing for many applications.
An axisymmetric, equatorial jet in Jupiter’s interior has a wavelike fluctuation with a 4-year period, revealing hidden aspects of the magnetic field within the metallic hydrogen region and constraining the dynamo that generates the magnetic field.