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Cryo-electron microscopy structures of the type 2 taste receptor TAS2R14 in complex with Ggust and Gi1 identify cholesterol as an orthosteric agonist and the bitter tastant cmpd28.1 as a positive allosteric modulator and agonist.
A newly developed RIPK3 inhibitor blocks necroptosis of lung cells, reduces lung inflammation and prevents mortality in a mouse model of influenza A virus infection.
The transcription factor FOXO1 has a key role in human T cell memory, and manipulating FOXO1 expression could provide a way to enhance CAR T cell therapies by increasing CAR T cell persistence and antitumour activity.
RMC-7977, a compound that exhibits potent inhibition of the active states of mutant and wild-type KRAS, NRAS and HRAS variants has a strong anti-tumour effect on RAS-addicted tumours and is well tolerated in preclinical models.
A new morganucodontan-like species from the Jurassic in China shows evidence of a loss of load-bearing function in the articular–quadrate jaw joint, which probably had a role in the evolution of the mammalian middle ear.
The molecular basis of OSCA/TMEM63 channel mechanosensitivity was investigated by determining 44 cryogenic electron microscopy structures of channels in different environments, expanding understanding of channel-mediated mechanotransduction and pore formation, with implications for two protein families.
We present a device that can reduce the phase-change memory reset current while maintaining a high on/off ratio, fast speed and small variations, representing advances for neuromorphic computing systems.
A comparison of two complete sets of human centromeres reveals that the centromeres show at least a 4.1-fold increase in single-nucleotide variation compared with their unique flanks, and up to 3-fold variation in size, resulting from an accelerated mutation rate.
Interim data from a clinical trial of mRNA-3927—an mRNA therapeutic for propionic acidaemia—provide early indications of the safety and efficacy of the treatment, and suggest that this approach might be applicable to other rare diseases.
Heat flows through thin, crack-like geo-compartments are shown to purify previously mixed compounds and enhance their reactivity, providing a selective mechanism for separating molecules relevant to the chemical origins of life.
Cryo-electron microscopy structures of the human Integrator complex in three different functional states shed light on how Integrator terminates RNA polymerase II (Pol II) transcription by disengaging Pol II from the DNA template.
An optical tweezer array of individual polyatomic molecules is created, revealing the obvious state control in the tweezer array and enabling further research on polyatomic molecules with diverse spatial arrangements.
An ensemble of cryo-electron microscopy structures of the KpsMT ABC transporter in complex with the KpsE co-polymerase and a glycolipid substrate reveal how capsular polysaccharides are recognized and translocated across bacterial cell membranes.
A metafluid with programmable compressibility, optical behaviour and viscosity is realized by mixing deformable spherical shells that undergo buckling within an incompressible fluid; the versatility of these metafluids opens up numerous opportunities for functionality.
A newly described fossil mammaliaform from the Jurassic period of China shows that the shuotheriids are allied to the docodonts, and provides details on the processes of tooth evolution in early mammals.