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  • Time-resolved cryo-EM is used to capture structural transitions during G-protein activation stimulated by a G-protein-coupled receptor.

    • Makaía M. Papasergi-Scott
    • Guillermo Pérez-Hernández
    • Georgios Skiniotis
    Article
  • A cluster randomized controlled trial in Sierra Leone shows that targeting access to vaccines in remote areas increases uptake, an approach that can be used to improve vaccine equity in developing countries.

    • Niccolò F. Meriggi
    • Maarten Voors
    • Ahmed Mushfiq Mobarak
    ArticleOpen Access
  • We introduce a scalable, high-resolution, 3D printing technique for the fabrication of shape-specific particles based on roll-to-roll continuous liquid interface production, enabling direct integration within biomedical, analytical and advanced materials applications.

    • Jason M. Kronenfeld
    • Lukas Rother
    • Joseph M. DeSimone
    ArticleOpen Access
  • We uncover key processes of the genomic evolution of small cell lung cancer under therapy, identify the common ancestor as the source of clonal diversity at relapse and show central genomic patterns associated with drug response.

    • Julie George
    • Lukas Maas
    • Roman K. Thomas
    ArticleOpen Access
  • A micro-fabricated Penning trap that operates at a 3 T magnetic field demonstrates full quantum control of an ion and the ability to transport the ion arbitrarily in the trapping plane above the chip.

    • Shreyans Jain
    • Tobias Sägesser
    • Jonathan Home
    ArticleOpen Access
  • A global high-resolution disaster footprint analytical model is developed to show substantial socioeconomic impacts from climatic change-driven heat stress through the global supply chain by 2060 due to direct and indirect effects on health and labour productivity.

    • Yida Sun
    • Shupeng Zhu
    • Dabo Guan
    ArticleOpen Access
  • A comparative analysis tests competing evolutionary hypotheses in toothed whales in which menopause has evolved many times as females extended their overall lifespan but not their reproductive lifespan, increasing their opportunity for intergenerational help without increasing intergenerational reproductive competition.

    • Samuel Ellis
    • Daniel W. Franks
    • Darren P. Croft
    ArticleOpen Access
  • Single-neuron and population activity in the macaque prefrontal and temporal cortex robustly encodes 24 species-typical behaviours, reciprocity in social interactions and social support.

    • Camille Testard
    • Sébastien Tremblay
    • Michael L. Platt
    Article
  • Cultivation of a new anoxygenic phototrophic bacterium from Boreal Shield lake water—representing a transition form in the evolution of photosynthesis—offers insights into how the major modes of phototrophy diversified.

    • J. M. Tsuji
    • N. A. Shaw
    • J. D. Neufeld
    ArticleOpen Access
  • Burning events that occur at night have been revealed as a driver of large wildfires. Prolonged drought conditions are to blame, making it easier for fires to spread at night when they would ordinarily slow or extinguish completely.

    • Jennifer K. Balch
    • Adam L. Mahood
    News & Views
  • It’s the end of the world as we know it.

    • Gretchen Tessmer
    Futures