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Scientists in Thailand have established that a tabby passed SARS-CoV-2 to a veterinary surgeon — although such cases of cat-to-human transmission are probably rare.
Cryo-electron microscopy structure, molecular dynamics and biochemical analyses of the SHOC2–PP1C–MRAS complex demonstrate the dependence of the complex formation on RAS–GTP and identify the determinants of RAS isoform preference for SHOC2–PP1C and specificity of the complex for RAF dephosphorylation.
Hypocrystalline ceramic aerogels with a zig-zag architecture show high thermal stability under thermal shock and exposure to high temperature, providing a reliable material system for thermal insulation at extreme conditions.
Structures of the Dcr-2–Loqs-PD complex while it is processing a double-stranded RNA (dsRNA) substrate elucidate the interactions between Dcr-2 and Loqs-PD, and show that Dcr-2 undergoes substantial conformational changes during a dsRNA-processing cycle.
Structural and biophysical analysis of the Arabidopsis thaliana auxin transporter PIN8 reveal that PIN transporters export auxin using an elevator mechanism.
Enteric viruses replicate in salivary glands, can be propagated in salivary gland-derived spheroids and cell lines, and are released into saliva, which is a new transmission route having implications for therapeutics, diagnostics and sanitation measures.
Suppression of salicylic acid production in Arabidopsisthaliana at high temperature is caused by decreased recruitment of GUANYLATE BINDING PROTEIN-LIKE 3 defence-associated condensates on promoter sites of master immune regulatory genes.
By intercalating layered 2D atomic crystals with selected chiral molecules, a new class of chiral molecular intercalation superlattices is reported, demonstrating highly ordered structures and achieving high tunnelling magnetoresistance and spin polarization ratios.
tDeclining YAP/TAZ mechanotransduction drives ageing by unleashing cGAS–STING signalling, a pillar of innate immunity, so sustaining YAP/TAZ mechanosignalling or inhibiting STING present promising approaches for limiting senescence-associated inflammation and improving healthy ageing.
The cryo-electron microscopy structure of the membrane-embedded ubiquitin ligase complex reveals its function as a retrotranslocation channel for shuttling mobile receptors out of peroxisomes.
Cryo-electron microscopy structures of Drosophila Dicer-2–R2D2 complexes with and without small interfering RNA reveal how the RNA is presented to Argonaute in the correct orientation for viral gene silencing.
A simple method for incorporating molecules into the gaps of stacked semimetallic materials through immersion offers an efficient way of filtering electrons, which could be useful for information-storage technologies.