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Frameshift mutations that create arginine-rich basic tails in transcription factors and other proteins can lead to altered phase separation in the nucleolus, which in turn leads to syndromes such as brachyphalangy, polydactyly and tibial aplasia.
This study demonstrates that bacteria use a ubiquitin transferase-like enzyme to prime cGAS/DncV-like nucleotidyltransferase activation and use a deubiquitinase-like enzyme to decrease activity.
A topological insulator, Bi2Te3, has been found to have spatially indirect spin-polarized excitonic states, opening the prospect of combining exciton and topological physics.
Disruption of TET2 increases the antitumour efficacy of CAR T cells, but establishes an epigenetic state that is prone to hyperproliferation and accumulation of secondary mutations.
We reconstruct the spatial distribution and timing of wetland loss through conversion to seven human land uses between 1700 and 2020, elucidating the magnitude and land-use drivers of global wetland losses to improve assessments of wetland loss impacts.
The simplicity of particle suspension reactors and the precise synthetic control afforded by silicon nanowire growth are used to develop a system that can produce hydrogen fuel by splitting water with sunlight.
A study using calcium imaging in the mouse forepaw system identifies neurons in the posterior insular cortex that respond to cooling and/or warming with distinct response dynamics.
A machine-learning-based strategy called CellOracle combines computational perturbation with modelling of gene-regulatory networks to analyse how cell identity is regulated by transcription factors, and correctly predicts phenotypic changes after transcription factor perturbation in the developing zebrafish.
An electrolyte design strategy based on a group of soft solvents is used to achieve lithium-ion batteries that operate safely under extreme conditions without lithium plating and with the capability of fast charging.
Tree-ring analysis is correlated with stable isotope data and historical texts to identify an unusual multi-year period of drought from around 1198 to 1196 bc associated with the collapse of the Hittite Empire.
By investigation of structural dynamics during the life cycle of Cu nanocatalysts, correlation of multimodal operando techniques was found to serve as a powerful platform to advance understanding of their complex structural evolution.
Dysfunctional telomeres activate innate immune responses through mitochondrial TERRA–ZBP1 complexes to eliminate cells that are destined for neoplastic transformation.
An analysis of rare coding variants across 22 common traits and diseases indicates that these variants will contribute substantially to biological insights but modestly to population risk stratification.
