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The physician-researcher who spoke out against misinformation during the COVID-19 pandemic says attacks against science are formidable — and getting worse.
The synthesis and isolation of a crystalline dication derived from a bis(imino)carbene through a two-electron oxidation/oxide-ion abstraction strategy is reported that bypasses the carbene radical cation, maintaining significant electrophilicity with two accessible vacant orbitals.
Heterogeneous geminal-atom catalysts, which pair single-atom sites in specific coordination and spatial proximity, offer a new avenue for the sustainable manufacture of fine chemicals.
Ground- and satellite-based air pollution data from 2000 to 2022 quantify the contribution of wildfire smoke to stagnation or reversal in PM2.5 concentration trends, showing that this contribution will grow as the climate continues to warm.
Reductive carboxylation of glutamine by isocitrate dehydrogenase 2 (IDH2) has a role in determining the fate of T cells, and inhibiting this enzyme promotes the differentiation of memory T cells.
The global population is increasingly exposed to daily landscape fire-sourced air pollution but there are socioeconomic disparities, with this pollution four times higher in low-income countries than in high-income countries during the period 2000–2019.
To demonstrate the power of multistability, a specific class of groovy metasheets is introduced as a new shape-morphing platform that allows repeated switching from the flat state to multiple, precisely selected and stable three-dimensional shapes.
Cellular lysine residues can be both methylated and acetylated on the same sidechain to form Nε-acetyl-Nε-methyllysine (Kacme), which is found on histone H4 across a range of species and across mammalian tissues and is associated with active chromatin.
Using cryo-EM, structures of three major assemblies of type A GABA receptors, which regulate brain excitability, are revealed in the mouse brain and provide a basis for the development of subtype-specific drugs.
A scalable total synthesis of portimines enables structural reassignment of portimine B and in-depth functional evaluation of portimine A, revealing that portimine A induces translation inhibition selectively in human cancer cells and is efficacious in vivo tumour-clearance models.
Conditional genetic ferret models enable ionocyte lineage tracing, ionocyte ablation and ionocyte-specific deletion of CFTR to elucidate the roles of pulmonary ionocyte biology and function during human health and disease.
Stress-associated catecholamines promote CD8+ T cell exhaustion through the β1-adrenergic receptor, and blocking β-adrenergic signalling may help restore anti-tumour functions.
An in vivo single-cell CRISPR screening method identifies transcriptional phenotypes of 22q11.2 deletion syndrome associated with a broad dysregulation of a class of disease susceptibility genes that are important for RNA processing and synaptic function.
The calvarial stem cell niche is populated by a cathepsin K-expressing cell lineage and a newly identified discoidin domain-containing receptor 2-expressing lineage, both of which are required for proper calvarial mineralization.
