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Quinuclidine-pyridone and sulfonamide-pyridone ligands enable transannular γ-methylene C–H arylation of cycloalkane carboxylic acids with a range of ring sizes, bringing us closer to molecular editing of saturated carbocycles.
We model occult preneoplasia by biallelic inactivation of TP53, a common early event in gastric cancer, in human gastric organoids, the results implying predictability in the earliest stages of tumorigenesis.
Detailed atomic models of axonemes from algal flagella and human respiratory cilia, which are hair-like protrusions from cells that enable motility and clear mucus from human airways, could provide insights into how they function.
The cycles of laser light have been used to advance transmission electron microscopy to attosecond time resolution, revealing the interactions between light and matter in terms of their fundamental dimensions in space and time.
A computational model based on a heuristic value function and forward search algorithm predicts human choices, response times and eye movements in games of games of four-in-a-row, and shows evidence for increased planning and improved attention with increased expertise.
Reconstruction of oceanic phosphorus concentrations during a large negative carbon-isotope excursion co-occurring with global oceanic oxygenation and evolution of some of Earth’s earliest animals suggests that decoupled phosphorus and ocean anoxia cycles during the Ediacaran may have prolonged the rise of atmospheric oxygen.
Records show that tropical water availability rather than temperature appears to have been increasingly controlling the interannual variability of the terrestrial carbon cycle over the past 59 years.
Using a specialized tip as a detector, the fingerprints of a single atom of iron and terbium are observed in synchrotron X-ray absorption spectra, allowing elemental and chemical characterization one atom at a time.
A study biochemically and structurally characterizes a lanmodulin from Hansschlegelia quercus with an oligomeric state sensitive to rare-earth ionic radius.
A context-aware, attention-based deep learning model pretrained on single-cell transcriptomes enables predictions in settings with limited data in network biology and could accelerate discovery of key network regulators and candidate therapeutic targets.
Combining alloy design with additive manufacturing process design creates α–β titanium–oxygen–iron alloys that are both strong and ductile, with the potential to revitalize off-grade sponge titanium and thereby reduce the carbon footprint of the titanium industry.
Skin tumour array by microporation (STAMP) captures the dynamic relationships of spatial, cellular and molecular components of tumour rejection and has the potential to translate therapeutic concepts into successful clinical strategies.
Mouse models show that myelin dysfunction and associated inflammation increase with age, which can promote amyloid-β deposition and therefore risk of developing Alzheimer’s disease.
