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An ultra-deep MUSE image of the mean Mg II emission for a sample of galaxies at redshift z ≈ 1 suggests the presence of bipolar outflows on scales of 10 kpc or more.
A study demonstrates that nucleotide modifications in mRNA-based therapeutics can lead to +1 ribosomal frameshifting during translation, yielding products that can trigger immune responses.
Experiments using conserved tumour models show that the G-protein-coupled receptor TkR99D in Drosophila Malphigian tubular stellate cells and NK3R in mouse renal tubules link malignant tumours to defective excretory functions.
By using several decades of hydrographic data and an inverse biogeochemical model that implicitly accounts for all known export pathways, a top-down estimate of the strength of the biological carbon pump is calculated.
A genomic constraint map for the human genome constructed using data from 76,156 human genomes from the Genome Aggregation Database shows that non-coding constrained regions are enriched for regulatory elements and variants associated with complex diseases and traits.
Cryogenic electron microscopy structures of amyloid filaments extracted from patient brains reveal that the protein TAF15 forms filaments that characterize certain cases of frontotemporal lobar degeneration.
By using a pump–probe atomic force microscopy detection scheme, electron spin transitions between non-equilibrium triplet states of individual pentacene molecules, as well as the ability to manipulate electron spins over tens of microseconds, is demonstrated.
Using single-cell and spatial transcriptomics, human embryonic limb development across space and time and the diversification and cross-species conservation of cells are demonstrated.
Single-cell transcriptomics studies on human and mouse non-small cell lung cancer and conditional knockout mouse models show that IL-4 from bone marrow basophils drives the development of granulocyte-monocyte progenitors to myeloid cells that suppress antitumour immunity.
Blood plasma protein data was combined with machine learning models for a simple method to determine differences in organ-specific aging; the study provides a basis for the prediction of diseases and aging effects using plasma proteomics.
An extensive global transcriptomics analysis of in vivo responses to 86 cytokines across more than 17 immune cell types reveals enormous complexity of cellular responses to cytokines, providing the basis of the Immune Dictionary and its companion software Immune Response Enrichment Analysis.
Silicon photonic nanocavities based on surface forces and conventional lithography and etching are developed, demonstrating pioneering technology that integrates atomic dimensions with the scalability of planar semiconductors.
Electron spin resonance is a standard method for studying the structure of chemical compounds, and it can also be used to control quantum spin states. Combining electron spin resonance with atomic force microscopy allows single spins to be manipulated in single molecules — with potential applications in quantum computing and elsewhere.
Ancient humans painted scenes in Indonesian caves more than 45,000 years ago, but their art is disappearing rapidly. Researchers are trying to discover what’s causing the damage and how to stop it — before the murals are gone forever.
