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  • Article |

    • Alfredo Quijano-Rubio
    • , Hsien-Wei Yeh
    • , Jooyoung Park
    • , Hansol Lee
    • , Robert A. Langan
    • , Scott E. Boyken
    • , Marc J. Lajoie
    • , Longxing Cao
    • , Cameron M. Chow
    • , Marcos C. Miranda
    • , Jimin Wi
    • , Hyo Jeong Hong
    • , Lance Stewart
    • , Byung-Ha Oh
    •  & David Baker

  • Article |

    A fossil of the Middle Jurassic haramiyidan Vilevolodon diplomylos with a well-preserved malleus, incus and ectotympanic sheds light on the evolutionary transition from a dual to a single function for the ossicles in mammals.

    • Junyou Wang
    • , John R. Wible
    • , Bin Guo
    • , Sarah L. Shelley
    • , Han Hu
    •  & Shundong Bi

  • Nature Briefing |

    Scientists welcome the US’s science-based plan, but see a tough road ahead. Plus, reminisce with Operation Warp Speed’s Moncef Slaoui and consider a different perspective on satellite images.

    • Flora Graham

  • Editorial |

    Nature’s third progress report, coming at the end of the pandemic’s first year, highlights key findings from epidemiology — from sounding the early alarm to following the impact of new variants.

  • Article |

    The identification of a lysosomal K+ channel complex—comprising AKT and the pore-forming TMEM175—provides insights into the mechanisms through which variants of the pore-forming protein affect the development of Parkinson’s disease.

    • Jinhong Wie
    • , Zhenjiang Liu
    • , Haikun Song
    • , Thomas F. Tropea
    • , Lu Yang
    • , Huanhuan Wang
    • , Yuling Liang
    • , Chunlei Cang
    • , Kimberly Aranda
    • , Joey Lohmann
    • , Jing Yang
    • , Boxun Lu
    • , Alice S. Chen-Plotkin
    • , Kelvin C. Luk
    •  & Dejian Ren

  • Article |

    An ultra-high-throughput multiplex protein–DNA binding assay is used to assess binding of 270 human transcription factors to 95,886 noncoding variants in the human genome, providing data to improve prediction of the effects of noncoding variants on transcription factor binding and thereby increase understanding of molecular pathways involved in diverse human traits and genetic diseases.

    • Jian Yan
    • , Yunjiang Qiu
    • , André M. Ribeiro dos Santos
    • , Yimeng Yin
    • , Yang E. Li
    • , Nick Vinckier
    • , Naoki Nariai
    • , Paola Benaglio
    • , Anugraha Raman
    • , Xiaoyu Li
    • , Shicai Fan
    • , Joshua Chiou
    • , Fulin Chen
    • , Kelly A. Frazer
    • , Kyle J. Gaulton
    • , Maike Sander
    • , Jussi Taipale
    •  & Bing Ren

  • Article |

    The insulin inhibitory receptor (inceptor) is identified as a negative regulator of insulin and IGF1 signalling that could be targeted for β-cell regeneration in treatments for diabetes.

    • Ansarullah
    • , Chirag Jain
    • , Fataneh Fathi Far
    • , Sarah Homberg
    • , Katharina Wißmiller
    • , Felizitas Gräfin von Hahn
    • , Aurelia Raducanu
    • , Silvia Schirge
    • , Michael Sterr
    • , Sara Bilekova
    • , Johanna Siehler
    • , Julius Wiener
    • , Lena Oppenländer
    • , Amir Morshedi
    • , Aimée Bastidas-Ponce
    • , Gustav Collden
    • , Martin Irmler
    • , Johannes Beckers
    • , Annette Feuchtinger
    • , Michal Grzybek
    • , Christin Ahlbrecht
    • , Regina Feederle
    • , Oliver Plettenburg
    • , Timo D. Müller
    • , Matthias Meier
    • , Matthias H. Tschöp
    • , Ünal Coskun
    •  & Heiko Lickert

  • News & Views |

    Scientists have long been baffled by the mismatch of climate simulations of the past 12,000 years with temperature reconstructions from geological records. It now emerges that seasonal biases in the records explain the disparity.

    • Jennifer Hertzberg

  • Article |

    The 2S–2P transitions in muonic helium-4 ions are measured using laser spectroscopy and used to obtain an α-particle charge-radius value five times more precise than that from electron scattering.

    • Julian J. Krauth
    • , Karsten Schuhmann
    • , Marwan Abdou Ahmed
    • , Fernando D. Amaro
    • , Pedro Amaro
    • , François Biraben
    • , Tzu-Ling Chen
    • , Daniel S. Covita
    • , Andreas J. Dax
    • , Marc Diepold
    • , Luis M. P. Fernandes
    • , Beatrice Franke
    • , Sandrine Galtier
    • , Andrea L. Gouvea
    • , Johannes Götzfried
    • , Thomas Graf
    • , Theodor W. Hänsch
    • , Jens Hartmann
    • , Malte Hildebrandt
    • , Paul Indelicato
    • , Lucile Julien
    • , Klaus Kirch
    • , Andreas Knecht
    • , Yi-Wei Liu
    • , Jorge Machado
    • , Cristina M. B. Monteiro
    • , Françoise Mulhauser
    • , Boris Naar
    • , Tobias Nebel
    • , François Nez
    • , Joaquim M. F. dos Santos
    • , José Paulo Santos
    • , Csilla I. Szabo
    • , David Taqqu
    • , João F. C. A. Veloso
    • , Jan Vogelsang
    • , Andreas Voss
    • , Birgit Weichelt
    • , Randolf Pohl
    • , Aldo Antognini
    •  & Franz Kottmann

  • Article |

    Multiplexed imaging of 3,660 chromosomal loci in individual mouse embryonic stem cells by DNA seqFISH+ with immunofluorescence of 17 chromatin marks and subnuclear structures reveals invariant organization of loci within individual cells, and heterogeneous and long-lived distinct combinatorial chromatin states in cellular subpopulations.

    • Yodai Takei
    • , Jina Yun
    • , Shiwei Zheng
    • , Noah Ollikainen
    • , Nico Pierson
    • , Jonathan White
    • , Sheel Shah
    • , Julian Thomassie
    • , Shengbao Suo
    • , Chee-Huat Linus Eng
    • , Mitchell Guttman
    • , Guo-Cheng Yuan
    •  & Long Cai

  • Article |

    Aneuploid cancer cell lines show increased dependence on the spindle assembly complex (SAC); initially they are resistant to SAC perturbations, but over time they accumulate chromosomal aberrations that impair their fitness.

    • Yael Cohen-Sharir
    • , James M. McFarland
    • , Mai Abdusamad
    • , Carolyn Marquis
    • , Sara V. Bernhard
    • , Mariya Kazachkova
    • , Helen Tang
    • , Marica R. Ippolito
    • , Kathrin Laue
    • , Johanna Zerbib
    • , Heidi L. H. Malaby
    • , Andrew Jones
    • , Lisa-Marie Stautmeister
    • , Irena Bockaj
    • , René Wardenaar
    • , Nicholas Lyons
    • , Ankur Nagaraja
    • , Adam J. Bass
    • , Diana C. J. Spierings
    • , Floris Foijer
    • , Rameen Beroukhim
    • , Stefano Santaguida
    • , Todd R. Golub
    • , Jason Stumpff
    • , Zuzana Storchová
    •  & Uri Ben-David

  • Article |

    Cancer cells that have undergone whole-genome doubling are more reliant than their near-diploid counterparts on DNA-replication factors, the spindle-assembly checkpoint and a mitotic kinesin protein, KIF18A.

    • Ryan J. Quinton
    • , Amanda DiDomizio
    • , Marc A. Vittoria
    • , Kristýna Kotýnková
    • , Carlos J. Ticas
    • , Sheena Patel
    • , Yusuke Koga
    • , Jasmine Vakhshoorzadeh
    • , Nicole Hermance
    • , Taruho S. Kuroda
    • , Neha Parulekar
    • , Alison M. Taylor
    • , Amity L. Manning
    • , Joshua D. Campbell
    •  & Neil J. Ganem

  • Article |

    An epidural spinal cord stimulation system regulates blood pressure in the acute and chronic phases of spinal cord injury.

    • Jordan W. Squair
    • , Matthieu Gautier
    • , Lois Mahe
    • , Jan Elaine Soriano
    • , Andreas Rowald
    • , Arnaud Bichat
    • , Newton Cho
    • , Mark A. Anderson
    • , Nicholas D. James
    • , Jerome Gandar
    • , Anthony V. Incognito
    • , Giuseppe Schiavone
    • , Zoe K. Sarafis
    • , Achilleas Laskaratos
    • , Kay Bartholdi
    • , Robin Demesmaeker
    • , Salif Komi
    • , Charlotte Moerman
    • , Bita Vaseghi
    • , Berkeley Scott
    • , Ryan Rosentreter
    • , Claudia Kathe
    • , Jimmy Ravier
    • , Laura McCracken
    • , Xiaoyang Kang
    • , Nicolas Vachicouras
    • , Florian Fallegger
    • , Ileana Jelescu
    • , YunLong Cheng
    • , Qin Li
    • , Rik Buschman
    • , Nicolas Buse
    • , Tim Denison
    • , Sean Dukelow
    • , Rebecca Charbonneau
    • , Ian Rigby
    • , Steven K. Boyd
    • , Philip J. Millar
    • , Eduardo Martin Moraud
    • , Marco Capogrosso
    • , Fabien B. Wagner
    • , Quentin Barraud
    • , Erwan Bezard
    • , Stéphanie P. Lacour
    • , Jocelyne Bloch
    • , Grégoire Courtine
    •  & Aaron A. Phillips

  • News & Views |

    The size of the helium nucleus has been determined using exotic helium atoms in which one electron has been replaced with its heavier cousin, a muon. The result sheds light on a decade-old puzzle regarding the proton radius.

    • Wilfried Nörtershäuser

  • Article |

    Trends in the rate of region- and sector-specific land-use greenhouse gas emissions in 1961–2017 show an acceleration of about 20% per decade after 2001.

    • Chaopeng Hong
    • , Jennifer A. Burney
    • , Julia Pongratz
    • , Julia E. M. S. Nabel
    • , Nathaniel D. Mueller
    • , Robert B. Jackson
    •  & Steven J. Davis

  • Article |

    X-ray diffraction measurements of solid carbon compressed to pressures of about two terapascals (approximately twenty million atmospheres) find that carbon retains a diamond structure even under these extreme conditions.

    • A. Lazicki
    • , D. McGonegle
    • , J. R. Rygg
    • , D. G. Braun
    • , D. C. Swift
    • , M. G. Gorman
    • , R. F. Smith
    • , P. G. Heighway
    • , A. Higginbotham
    • , M. J. Suggit
    • , D. E. Fratanduono
    • , F. Coppari
    • , C. E. Wehrenberg
    • , R. G. Kraus
    • , D. Erskine
    • , J. V. Bernier
    • , J. M. McNaney
    • , R. E. Rudd
    • , G. W. Collins
    • , J. H. Eggert
    •  & J. S. Wark

  • Article |

    The global abundance of oceanic sharks and rays has decreased by 71% since 1970 and 24 species are threatened with extinction owing to a concomitant increase in fishing pressure.

    • Nathan Pacoureau
    • , Cassandra L. Rigby
    • , Peter M. Kyne
    • , Richard B. Sherley
    • , Henning Winker
    • , John K. Carlson
    • , Sonja V. Fordham
    • , Rodrigo Barreto
    • , Daniel Fernando
    • , Malcolm P. Francis
    • , Rima W. Jabado
    • , Katelyn B. Herman
    • , Kwang-Ming Liu
    • , Andrea D. Marshall
    • , Riley A. Pollom
    • , Evgeny V. Romanov
    • , Colin A. Simpfendorfer
    • , Jamie S. Yin
    • , Holly K. Kindsvater
    •  & Nicholas K. Dulvy

  • News & Views |

    Insulin is produced by pancreatic β-cells. The identification of a regulator of insulin signalling in these cells cements the long-standing idea that this pathway has a key role in β-cell biology.

    • Rohit N. Kulkarni

  • News & Views |

    Newly discovered fossil evidence has led to a re-evaluation of one of the fundamental transitions in mammalian evolution: the transformation of bones of the lower jaw into those of the middle ear.

    • Simone Hoffmann

  • Article |

    Recordings of cells in the human dorsomedial prefrontal cortex identify a population of neurons that encode information about others’ beliefs and distinguish them from self-belief-related representations, providing insight into cellular-level processing underlying human theory of mind.

    • Mohsen Jamali
    • , Benjamin L. Grannan
    • , Evelina Fedorenko
    • , Rebecca Saxe
    • , Raymundo Báez-Mendoza
    •  & Ziv M. Williams

  • Article
    | Open Access

    The genome of the biofuel crop switchgrass (Panicum virgatum) reveals climate–gene–biomass associations that underlie adaptation in nature and will facilitate improvements of the yield of this crop for bioenergy production.

    • John T. Lovell
    • , Alice H. MacQueen
    • , Sujan Mamidi
    • , Jason Bonnette
    • , Jerry Jenkins
    • , Joseph D. Napier
    • , Avinash Sreedasyam
    • , Adam Healey
    • , Adam Session
    • , Shengqiang Shu
    • , Kerrie Barry
    • , Stacy Bonos
    • , LoriBeth Boston
    • , Christopher Daum
    • , Shweta Deshpande
    • , Aren Ewing
    • , Paul P. Grabowski
    • , Taslima Haque
    • , Melanie Harrison
    • , Jiming Jiang
    • , Dave Kudrna
    • , Anna Lipzen
    • , Thomas H. Pendergast IV
    • , Chris Plott
    • , Peng Qi
    • , Christopher A. Saski
    • , Eugene V. Shakirov
    • , David Sims
    • , Manoj Sharma
    • , Rita Sharma
    • , Ada Stewart
    • , Vasanth R. Singan
    • , Yuhong Tang
    • , Sandra Thibivillier
    • , Jenell Webber
    • , Xiaoyu Weng
    • , Melissa Williams
    • , Guohong Albert Wu
    • , Yuko Yoshinaga
    • , Matthew Zane
    • , Li Zhang
    • , Jiyi Zhang
    • , Kathrine D. Behrman
    • , Arvid R. Boe
    • , Philip A. Fay
    • , Felix B. Fritschi
    • , Julie D. Jastrow
    • , John Lloyd-Reilley
    • , Juan Manuel Martínez-Reyna
    • , Roser Matamala
    • , Robert B. Mitchell
    • , Francis M. Rouquette Jr
    • , Pamela Ronald
    • , Malay Saha
    • , Christian M. Tobias
    • , Michael Udvardi
    • , Rod A. Wing
    • , Yanqi Wu
    • , Laura E. Bartley
    • , Michael Casler
    • , Katrien M. Devos
    • , David B. Lowry
    • , Daniel S. Rokhsar
    • , Jane Grimwood
    • , Thomas E. Juenger
    •  & Jeremy Schmutz

  • News & Views |

    For those fortunate enough to have survived a deadly disease, a vital question remains: how long does their hard-earned immunity last? Tracking of antibodies in Ebola survivors reveals a surprising pattern.

    • Courtney Woolsey
    •  & Thomas W. Geisbert

  • Article |

    The inflammasome receptor AIM2 acts independently of the inflammasome to reduce autoimmunity and stabilize regulatory T cells.

    • Wei-Chun Chou
    • , Zengli Guo
    • , Hao Guo
    • , Liang Chen
    • , Ge Zhang
    • , Kaixin Liang
    • , Ling Xie
    • , Xianming Tan
    • , Sara A. Gibson
    • , Elena Rampanelli
    • , Yan Wang
    • , Stephanie A. Montgomery
    • , W. June Brickey
    • , Meng Deng
    • , Leslie Freeman
    • , Song Zhang
    • , Maureen A. Su
    • , Xian Chen
    • , Yisong Y. Wan
    •  & Jenny P.-Y. Ting

  • Article |

    Data from ocean bottom seismometers show that the mantle transition zone beneath the equatorial Mid-Atlantic Ridge is thin and warm, which suggests more material transfer than previously thought.

    • Matthew R. Agius
    • , Catherine A. Rychert
    • , Nicholas Harmon
    • , Saikiran Tharimena
    •  & J.-Michael Kendall

  • Article |

    Binding of METTL3 to chromatin is enriched over IAP family endogenous retroviral elements in mouse embryonic stem cells, helping to ensure the integrity of heterochromatin at these elements.

    • Wenqi Xu
    • , Jiahui Li
    • , Chenxi He
    • , Jing Wen
    • , Honghui Ma
    • , Bowen Rong
    • , Jianbo Diao
    • , Liyong Wang
    • , Jiahua Wang
    • , Feizhen Wu
    • , Li Tan
    • , Yujiang Geno Shi
    • , Yang Shi
    •  & Hongjie Shen

  • Article |

    In many survivors of Ebola virus infection, antibody responses show long-term patterns of decline followed by restimulation, possibly owing to recrudescence of persisting virus.

    • Charlene Adaken
    • , Janet T. Scott
    • , Raman Sharma
    • , Robin Gopal
    • , Steven Dicks
    • , Saidia Niazi
    • , Samreen Ijaz
    • , Tansy Edwards
    • , Catherine C. Smith
    • , Christine P. Cole
    • , Philip Kamara
    • , Osman Kargbo
    • , Heidi A. Doughty
    • , Johan van Griensven
    • , Peter W. Horby
    • , Sahr M. Gevao
    • , Foday Sahr
    • , M. G. Semple
    • , J. T. Scott
    • , S. M. Gevao
    • , F. Sahr
    • , C. P. Cole
    • , J. Russell
    • , S. Baker
    • , O. Kargbo
    • , P. Kamara
    • , M. Lado
    • , C. S. Brown
    • , B. Conton
    • , J. van Griensven
    • , R. Ravinetto
    • , Y. Claeys
    • , R. S. Tedder
    • , R. Gopal
    • , T. J. G. Brooks
    • , C. C. Smith
    • , H. A. Doughty
    • , A. Mari Saez
    • , A. H. Kelly
    • , J. K. Baillie
    • , N. Shindo
    • , D. Pfeifer
    • , D. L. Hoover
    • , W. A. Fischer II
    • , D. A. Wohl
    • , N. M. Thielman
    • , P. W. Horby
    • , L. Merson
    • , P. G. Smith
    • , T. Edwards
    • , Richard J. Dimelow
    • , Richard S. Tedder
    • , Malcolm G. Semple
    • , William A. Paxton
    •  & Georgios Pollakis