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Protomelission-like macrofossils from the Xiaoshiba Lagerstätte show features characteristic of dasycladalean green alga, suggesting that Protomelission is unlikely to be an early bryozoan.
Information from natural protein libraries was extracted and used to design heteropolymer ensembles as mixtures of disordered, partially folded and folded proteins, providing valuable guiding principles to synthetically realize protein properties.
Structural and biochemical studies of the Mycobacterium smegmatis hydrogenase Huc provides insights into how [NiFe] hydrogenases oxidize trace amounts of atmospheric hydrogen and transfer the electrons liberated via quinone transport.
A small population of prostaglandin E2-responsive glossopharyngeal sensory neurons provides a sensory pathway between airway and brainstem that mediates sickness responses to early-phase influenza virus infection.
Inhibition of the tricarboxylic acid cycle enzyme fumarate hydratase leads to deregulation of cytokine production in macrophages, which has implications in human diseases such as systemic lupus erythematosus.
Biochemical and molecular dynamics studies show that the third intracellular loop of G protein-coupled receptors autoregulates the receptor activity and tunes the signalling specificity by controlling access to the G protein-binding site.
A spatial and temporal compilation of geochemical data documents a stepwise transgression of toxic euxinic waters into shallow oceans that drove a series of Late Devonian extinction events.
Effective anti-PD-1 immunotherapy is associated with the presence of polyclonal CD8+ T cells in the tumour and blood specific for a limited number of immunodominant mutations, which are recurrently recognized over time.