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Integrated analyses of bromalites provide robust pictures of past food webs, explaining early dinosaur evolution and the emergence of larger dinosaur faunas with new feeding patterns.
Soils from 30 grasslands across Europe were subjected to 4 contrasting extreme climatic events under drought, flood, freezing and heat conditions, with the results suggesting that soil microbiomes from different climates share unified responses to extreme climatic events.
Optimizing study design is critical for increasing standardized effect sizes and replicability, and the features that increase replicability in cross-sectional and longitudinal brain-wide association studies are explored.
Biochemical and structural studies of the loading pathway of the human MCM2–7 replicative helicase motor reveal differences from the orthologous yeast system that may increase resilience against challenges faced by multicellular organisms.
Biochemical and structural studies of the human MCM replicative DNA helicase complex show differences from the yeast complex and provide insights into mechanisms of double hexamer assembly on sequence-independent replication origins.
Using a graphene quantum dot creation and a wavefunction mapping technique, quantum scars are directly visualized for Dirac electrons with a scanning tunnelling microscope.
Strain richness of gut microbiota ecosystems is a key characteristic underpinning engraftment in faecal microbiota transplantation, and could improve the design of defined live biotherapeutic products with predictable outcomes.
The phase 3 SONIA trial challenges the benefits of using cyclin-dependent kinase 4 and 6 inhibitors as a first-line compared with second-line treatment.
A review of the literature on artificial intelligence systems to examine openness reveals that open AI systems are actually closed, as they are highly dependent on the resources of a few large corporate actors.
We evaluate the effects in humans of interleukin-15 co-expression on glypican-3 (GPC3) chimeric antigen receptor (CAR) T cells and demonstrate that IL-15 increases the expansion, intratumoural survival and antitumour activity of GPC3 (expressed in a group of solid cancers) CAR T cells.
Multi-modal transcriptomic analyses of the sympathetic nervous system reveal organ-specific neural innervation and modular regulation of visceral functions.