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Frontier, the first machine to break supercomputing’s exascale speed barrier, is giving researchers unprecedented insights into everything from atoms to galaxies.

Andrew Robinson reviews five of the best science picks.

A lack of funding and academic freedom amid a political crackdown leave scientists feeling hopeless and pondering an exodus from the country.

The medication is the first in decades to have a different mode of action than do current drugs, achieving better symptom relief with fewer side effects.

It’s easy to feel awkward or overstimulated in a conference environment. Nature sought advice on how to avoid moments of panic while giving talks or discussing your research.

The Square Kilometre Array will take longer to expand further into eight African nations than originally planned.

The arrival of the first disease-modifying therapy for Alzheimer’s was significant, but it was not met with the joy that might have been expected.

The discovery and validation of a diagnostic marker in plasma could be an important step for monitoring disease progression.

Mutations in the gene encoding APP, the precursor to amyloid-β, are found to underpin some cases of familial Alzheimer’s disease.

Genetic evidence kick-starts research into the involvement of microglia cells and the innate immune system in the development of the disease.

Immunizing mice against amyloid-β is shown not only to prevent plaques forming, but also to clear away existing deposits.

Evidence mounts that these peptides are the key component of plaques associated with Alzheimer’s and might give rise to the disease.

The fundamental discovery deepens scientists’ understanding of chemical bonding.

Wetlands ecologist Sigit Sasmito describes how growing up in rural Indonesia influenced his interest in peatlands and mangroves.

The APOE gene, which codes for a fat-binding protein in the brain, is identified as a strong genetic risk factor for the most common form of the disease.

A study of nearly 75,000 people doubled the number of areas of the human genome that were known to be associated with late-onset disease.

A survey of early-career academics finds that one in four is considering moving abroad amid concerns of stigmatization from some international colleagues.