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A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation and sequence variation.
Imaging of a Devonian jawless fish reveals advanced features previously thought to be exclusive to jawed vertebrates, challenging the idea that jaws were the primary driver for the evolution of derived traits in the vertebrate body plan.
N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network without inducing autoinflammatory responses.
Using an advanced imaging system called EyeRIS, locomotion in deep-sea octopuses could be studied, revealing simplified crawling patterns that could inspire the design of robots.
Microglia-derived IGF1 promotes the proliferation of GABAergic progenitors and neuroblasts in the human medial ganglionic eminence, contributing to the extended production of GABAergic neurons and an expanded cognitive capacity in the human brain.
A highly potent and selective small-molecule catalytic inhibitor of the protein lysine methyltransferase NSD2 shows therapeutic efficacy in preclinical models of KRAS-driven pancreatic cancer and lung cancer.
Doppler-free laser spectroscopy is used to measure with high precision a rovibrational transition frequency of trapped and cooled \({{\rm{H}}}_{2}^{+}\) ions.
