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  • Article |

    • Katherine McMahan
    • , Jingyou Yu
    • , Noe B. Mercado
    • , Carolin Loos
    • , Lisa H. Tostanoski
    • , Abishek Chandrashekar
    • , Jinyan Liu
    • , Lauren Peter
    • , Caroline Atyeo
    • , Alex Zhu
    • , Esther A. Bondzie
    • , Gabriel Dagotto
    • , Makda S. Gebre
    • , Catherine Jacob-Dolan
    • , Zhenfeng Li
    • , Felix Nampanya
    • , Shivani Patel
    • , Laurent Pessaint
    • , Alex Van Ry
    • , Kelvin Blade
    • , Jake Yalley-Ogunro
    • , Mehtap Cabus
    • , Renita Brown
    • , Anthony Cook
    • , Elyse Teow
    • , Hanne Andersen
    • , Mark G. Lewis
    • , Douglas A. Lauffenburger
    • , Galit Alter
    •  & Dan H. Barouch

  • Author Correction |

    • Irene Caffa
    • , Vanessa Spagnolo
    • , Claudio Vernieri
    • , Francesca Valdemarin
    • , Pamela Becherini
    • , Min Wei
    • , Sebastian Brandhorst
    • , Chiara Zucal
    • , Else Driehuis
    • , Lorenzo Ferrando
    • , Francesco Piacente
    • , Alberto Tagliafico
    • , Michele Cilli
    • , Luca Mastracci
    • , Valerio G. Vellone
    • , Silvano Piazza
    • , Anna Laura Cremonini
    • , Raffaella Gradaschi
    • , Carolina Mantero
    • , Mario Passalacqua
    • , Alberto Ballestrero
    • , Gabriele Zoppoli
    • , Michele Cea
    • , Annalisa Arrighi
    • , Patrizio Odetti
    • , Fiammetta Monacelli
    • , Giulia Salvadori
    • , Salvatore Cortellino
    • , Hans Clevers
    • , Filippo De Braud
    • , Samir G. Sukkar
    • , Alessandro Provenzani
    • , Valter D. Longo
    •  & Alessio Nencioni

  • Author Correction |

    • Mark O. Cuthbert
    • , Richard G. Taylor
    • , Guillaume Favreau
    • , Martin C. Todd
    • , Mohammad Shamsudduha
    • , Karen G. Villholth
    • , Alan M. MacDonald
    • , Bridget R. Scanlon
    • , D. O. Valerie Kotchoni
    • , Jean-Michel Vouillamoz
    • , Fabrice M. A. Lawson
    • , Philippe Armand Adjomayi
    • , Japhet Kashaigili
    • , David Seddon
    • , James P. R. Sorensen
    • , Girma Yimer Ebrahim
    • , Michael Owor
    • , Philip M. Nyenje
    • , Yahaya Nazoumou
    • , Ibrahim Goni
    • , Boukari Issoufou Ousmane
    • , Tenant Sibanda
    • , Matthew J. Ascott
    • , David M. J. Macdonald
    • , William Agyekum
    • , Youssouf Koussoubé
    • , Heike Wanke
    • , Hyungjun Kim
    • , Yoshihide Wada
    • , Min-Hui Lo
    • , Taikan Oki
    •  & Neno Kukuric

  • Outlook |

    A condition whose impact goes far beyond adverse reactions.

    • David Payne

  • Perspective |

    Recent work on optical computing for artificial intelligence applications is reviewed and the potential and challenges of all-optical and hybrid optical networks are discussed.

    • Gordon Wetzstein
    • , Aydogan Ozcan
    • , Sylvain Gigan
    • , Shanhui Fan
    • , Dirk Englund
    • , Marin Soljačić
    • , Cornelia Denz
    • , David A. B. Miller
    •  & Demetri Psaltis

  • Article |

    Data augmentation and a self-correcting design are used to develop a reinforcement-learning algorithm for the autonomous navigation of Loon superpressure balloons in challenging stratospheric weather conditions.

    • Marc G. Bellemare
    • , Salvatore Candido
    • , Pablo Samuel Castro
    • , Jun Gong
    • , Marlos C. Machado
    • , Subhodeep Moitra
    • , Sameera S. Ponda
    •  & Ziyu Wang

  • Article |

    Expression of three Yamanaka transcription factors in mouse retinal ganglion cells restores youthful DNA methylation patterns, promotes axon regeneration after injury, and reverses vision loss in a mouse model of glaucoma and in aged mice, suggesting that mammalian tissues retain a record of youthful epigenetic information that can be accessed to improve tissue function.

    • Yuancheng Lu
    • , Benedikt Brommer
    • , Xiao Tian
    • , Anitha Krishnan
    • , Margarita Meer
    • , Chen Wang
    • , Daniel L. Vera
    • , Qiurui Zeng
    • , Doudou Yu
    • , Michael S. Bonkowski
    • , Jae-Hyun Yang
    • , Songlin Zhou
    • , Emma M. Hoffmann
    • , Margarete M. Karg
    • , Michael B. Schultz
    • , Alice E. Kane
    • , Noah Davidsohn
    • , Ekaterina Korobkina
    • , Karolina Chwalek
    • , Luis A. Rajman
    • , George M. Church
    • , Konrad Hochedlinger
    • , Vadim N. Gladyshev
    • , Steve Horvath
    • , Morgan E. Levine
    • , Meredith S. Gregory-Ksander
    • , Bruce R. Ksander
    • , Zhigang He
    •  & David A. Sinclair

  • Nature Briefing |

    The UK will start to roll out the Pfizer–BioNTech vaccine within days. Plus, China’s Chang’e-5 spacecraft successfully lands on the Moon and we are ‘within striking distance’ of the Paris climate goals.

    • Flora Graham

  • News Feature |

    Delirium is very common on COVID wards. Researchers are testing whether these temporary bouts of confusion could bring on permanent cognitive decline.

    • Carrie Arnold

  • Outlook |

    ‘Itch-proof’ cosmetics, keeping inflammation-causing T cells in check, and other highlights from allergy and immunology studies.

    • Elizabeth Svoboda

  • News & Views |

    Neurons progressively deteriorate with age and lose resilience to injury. It emerges that treatment with three transcription factors can re-endow neurons in the mature eye with youthful characteristics and the capacity to regenerate.

    • Andrew D. Huberman

  • Spotlight |

    Researchers and officials reveal how the pandemic has shifted the country’s scientific landscape and global reputation.

    • Flynn Murphy

  • Outlook |

    Early disruptions in the composition of the gut microbiome can directly influence digestive and immune function in ways that put children at greater risk.

    • Michael Eisenstein

  • Comment |

    Unleash the ocean’s potential to boost economies sustainably while addressing climate change, food security and biodiversity.

    • Jane Lubchenco
    • , Peter M. Haugan
    •  & Mari Elka Pangestu

  • News & Views |

    Microscopy methods that reveal the spatial patterns of individual types of microbe are limited by the number of different species that can be monitored together. A new technique now provides progress on this front.

    • Jen Nguyen
    •  & Carolina Tropini

  • News & Views |

    An artificially intelligent controller can station a stratospheric balloon for weeks at a time without full knowledge of surrounding winds, opening up the prospect of unsupervised environmental monitoring.

    • Scott M. Osprey

  • Futures |

    The lie of the land.

    • John Gilbey

  • Outlook |

    Bullying, anxiety and depression can have a huge impact on the lives of people with allergies and their families.

    • Roxanne Khamsi

  • Article |

    A cryo-electron microscopy structure of the yeast pheromone receptor Ste2, a class D G-protein-coupled receptor, in its active state reveals that Ste2 is a homodimer that couples to two G proteins.

    • Vaithish Velazhahan
    • , Ning Ma
    • , Gáspár Pándy-Szekeres
    • , Albert J. Kooistra
    • , Yang Lee
    • , David E. Gloriam
    • , Nagarajan Vaidehi
    •  & Christopher G. Tate

  • Article |

    Time-resolved serial femtosecond crystallography is used to reveal the structural changes that stabilize the charge-separation steps of electron-transfer reactions in the photosynthetic reaction centre of Blastochloris viridis on a timescale of picoseconds.

    • Robert Dods
    • , Petra Båth
    • , Dmitry Morozov
    • , Viktor Ahlberg Gagnér
    • , David Arnlund
    • , Hoi Ling Luk
    • , Joachim Kübel
    • , Michał Maj
    • , Adams Vallejos
    • , Cecilia Wickstrand
    • , Robert Bosman
    • , Kenneth R. Beyerlein
    • , Garrett Nelson
    • , Mengning Liang
    • , Despina Milathianaki
    • , Joseph Robinson
    • , Rajiv Harimoorthy
    • , Peter Berntsen
    • , Erik Malmerberg
    • , Linda Johansson
    • , Rebecka Andersson
    • , Sergio Carbajo
    • , Elin Claesson
    • , Chelsie E. Conrad
    • , Peter Dahl
    • , Greger Hammarin
    • , Mark S. Hunter
    • , Chufeng Li
    • , Stella Lisova
    • , Antoine Royant
    • , Cecilia Safari
    • , Amit Sharma
    • , Garth J. Williams
    • , Oleksandr Yefanov
    • , Sebastian Westenhoff
    • , Jan Davidsson
    • , Daniel P. DePonte
    • , Sébastien Boutet
    • , Anton Barty
    • , Gergely Katona
    • , Gerrit Groenhof
    • , Gisela Brändén
    •  & Richard Neutze

  • Article |

    Ultrasonic vocalizations of male mice distinguish aggressive, male-directed mounting from reproductive, female-directed mounting behaviours, which are represented by distinct ESR1-expressing populations of neurons in the ventromedial hypothalamus and medial preoptic area, respectively.

    • Tomomi Karigo
    • , Ann Kennedy
    • , Bin Yang
    • , Mengyu Liu
    • , Derek Tai
    • , Iman A. Wahle
    •  & David J. Anderson