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An aromatic metallo-annulene, comprising a 15-carbon macrocycle enclosing an osmium complex, with the metal residing within the plane of the macrocycle is reported.
Multimodal results (iEEG, fMRI and MEG) of predictions from integrated information theory and global neuronal workspace theory align with some predictions of both theories on visual consciousness, but also critically challenge key tenets of both theories.
Experiments in mouse models show that proper recovery of the intestinal microbiota following depletion, with or without faecal microbiota transplant therapy, is dependent on syntrophic interactions that occur only with specific dietary interventions.
In response to phage infection, the Toll/interleukin-1 receptor (TIR) domain protein ThsB of the type II Thoeris defence system produces histidine conjugated to ADP-ribose, which stimulates bacterial defence by interacting with the Macro domain of the ThsA membrane effector protein.
Total cell cycle duration is a key hallmark of cancer initiation, and determines whether defects in apoptosis, senescence, immune surveillance, angiogenesis, DNA repair, polarity and proliferation lead to cancer development.
A size-sieved complex precipitation in Sc-added Al–Mg alloys achieves a high-density dispersion of both fine Al3Sc nanoprecipitates and in situ formed core-shell Al3(Mg, Sc)2/Al3Sc nanophases with high hydrogen-trapping ability.
A collaborative study initiated by the sovereign nation of Picuris Pueblo in the Northern Rio Grande region of New Mexico addresses gaps in traditional knowledge and furthers understanding of their population history and ancestry.
An analysis of data from 522 population-based studies encompassing 82 global regions and spanning more than a century (1920–2024) shows spatiotemporal transitions across epidemiologic stages 1 to 3 of inflammatory bowel disease, and models stage 4 progression.
Global data collected between 2014 and 2024 provide insights into the distribution and potential transport mechanisms of subsurface microplastics throughout the oceanic water column.
Geochemistry and geochronology show that Samoa and Rurutu–Arago are the longest-lived Pacific hotspots, providing better constraints on plate rotation and support for a link between the Louisville volcanic track and the Ontong Java Nui Plateau.
Increasing the activity of individual parvalbumin-expressing interneurons in the mouse brain modulates the number and strength of inhibitory parvalbumin synapses received by these cells through changes in the expression of the neuropeptide-encoding genes Vgf and Scg2.
A life cycle assessment study is used to examine the impacts of advanced cooling technologies on cloud infrastructure, from virtual machines to server architecture, data centre buildings and the grid.
Inhibition of a cardiac stroma-enriched mechanosensor, SRC—in concert with suppression of the TGFβ pathway—potentiates the reversal of fibroblast activation and alleviates contractile dysfunction in fibrotic hearts.
Aversive and rewarding social experiences are linked to conspecific identity through converging dorsal raphe 5-HT and paraventricular nucleus of the thalamus neurotensin signals in the vCA1 that instruct opposing valence, representing a synaptic switch for flexible social valence computation.
A nanofluidic intracellular delivery (NanoFLUID) patch provides a versatile, biocompatible and efficient method for the targeted delivery of payloads to internal organs for therapeutic purposes and for biomolecular investigations.
