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Regioselective functionalization of aliphatic carbon–hydrogen bonds is achieved using frustrated radical pairs generated from disilazide donors and an N-oxoammonium acceptor.
Three-dimensional deep neural networks can be trained to forecast global weather patterns, including extreme weather, with accuracy greater than or equal to that of the best numerical weather prediction models.
Induction of APOBEC3A in response to targeted therapies drives evolution of drug-tolerant persister cells, suggesting that its suppression may represent a potential therapeutic strategy in the prevention of acquired resistance to lung cancer targeted therapy.
Cryo-EM structures and analysis provide insight into the mechanisms by which basic helix–loop–helix transcription factors access E-box DNA sequences that are embedded within nucleosomes, and cooperate with other transcription factors.
Measurements from the Chang’e-1 and Chang’e-2 microwave instruments reveal an anomalously hot geothermal source on the Moon that is best explained by a roughly 50-kilometre-diameter granitic system below the geological feature known as Compton–Belkovich.
Hepatitis C virus utilizes flavin adenine dinucleotide as a non-canonical initiating nucleotide for the viral RNA polymerase, resulting in 5′ capping of viral RNA, which provides protection against the host innate immune response.
Competition for glutamine between type-1 conventional dendritic cells and tumour cells has a central role in tuning the anti-tumour immune response and in immune evasion by cancer cells.
A method is presented to harness the paper-folding mechanism of reconfigurable macroscale systems to create reconfigurable DNA origami structures, in anticipation that it will advance the development of complex molecular systems.
An analysis proposes the social value of offsets to measure the amount of carbon that should be stored in temporary and risky offsets to compensate one ton of CO2 emissions.
A new nowcasting model unifies physical-evolution schemes and deep-learning methods to accurately predict precipitation with lead times of up to 3 h, including extreme-precipitation events and weather systems that were previously considered intractable with physics-based numerical methods.
The orbital Hall effect is observed in the light metal titanium, confirming the orbital Hall effect and indicating that orbital angular momentum is an important degree of freedom in solids.
Observations and samples from the central Himalayas show that a giant rockslide occurring around 1190 ad in the Annapurna massif led to the collapse of an elevated palaeo-summit, illustrating the episodic mode of erosion of the glaciated high relief by mega-rockslides.
