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The catalytic asymmetric polyene cyclization of homofarnesol to ambrox is achieved using a highly Brønsted-acidic and confined imidodiphosphorimidate catalyst.
Cryo-electron microscopy structures of the noradrenaline transporter (NET) reveal binding modes of adrenaline, coordination of sodium and chloride ion binding and the binding sites and mechanisms of inhibition by conotoxin, bupropion and ziprasidone.
In Drosophila, dopamine sets motivational state during mating by regulating the integration of competing drives in copulation decision neurons, potentially indicative of a more general role for control over neuronal integration time in the regulation of behavioural decisions.
Serotonin has a role in ependymoma tumorigenesis through modifying histones and thereby regulating key transcription factors and activating specific oncogenic transcriptional networks in brain cells.
Cryo-electron microscopy structures of NMDA receptors in open and apo states reveal the molecular mechanism underlying the dual ligand requirement for its channel gating and opening.
FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular mechanism that reconciles the roles of FANCD2–FANCI in the recognition and protection of stalled replication forks.
Youti yuanshi is a euarthropod species newly described from a fossilized larva from Yunnan Province, China dating approximately to late Atdabanian stage, Cambrian period, and provides insights into the evolution of arthropods.
A study links environmental nitrosamines to bladder cancer through their metabolism by specific commensal microorganisms occurring in the gastrointestinal tract of humans and mice.
X-ray computed tomography is combined with burst ptychography and filtered back-propagation to achieve high-speed, three-dimensional imaging of features as small as 4 nm.
This Review examines the diverse strategies utilized by naturally occurring antibiotics and suggests how they have provided, and will in future provide, inspiration for the design of novel antibiotics.
Nasal vaccination induces B cell expansion in the nasal-associated lymphoid tissues, followed by homing to the nasal turbinates and glandular acinar structures.
Using osmium isotopes, the 2021 Fagradalsfjall lavas in Iceland are shown to be both fractionally crystallized and strongly crustally contaminated, probably by mid-ocean-ridge gabbros and older basalts underlying the Reykjanes Peninsula.
Propofol repairs malfunctioning mutant HCN1 channels associated with epilepsy, and its unusual mechanism of action on these ion channels can potentially be exploited to design precision drugs targeting HCN channelopathies.
This study of immunological memory diversity in the human upper airway provides new understanding of immune memory at a major mucosal barrier tissue in humans.
We find that rhinoceros beetles passively deploy and retract their hindwings without muscular activity, demonstrating this with insect-like microrobots.
Structures of fetal and adult muscle acetylcholine receptors reveal a developmental switch that alters channel biophysics and pharmacology to enable neuromuscular junction maturation, uncovering pathogenic mechanisms underlying congenital myasthenic syndromes.
Two photonic platforms using a convolutional processing system with partially coherent light sources is shown to boost computing parallelism, demonstrated using the classification of gaits of patients with Parkinson’s disease and the MNIST handwritten digits dataset.
