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A self-driving lab system spent half a year engineering enzymes to work at higher temperatures.

Detectors at the Large Hadron Collider spot the famed particle decaying into a photon and a ‘Z boson’.

Physicians rely on algorithms for personalized medicine — but an analysis of schizophrenia trials shows the tools fail to adapt to new data sets.

The heat stored in the world’s oceans increased by the greatest margin ever in 2023.

Researchers are cautiously optimistic that the neglected tropical disease could be gone by 2030, but new barriers — including antibiotic resistance and primate reservoirs — might stand in the way.

Permian-period petroleum helped to preserve minute scraps of pebbly hide that probably belonged to a lizard-like creature.

Allegations against Claudine Gay have left researchers arguing over academic standards and practices.

GPS data reveal that young people encounter fewer individuals from diverse groups than do adults. The isolation of young people is exacerbated in larger cities, and for those living in poverty.

Materials that adhere tightly to human tissues can promote healing and boost the sensitivity of biomedical diagnostic devices. An ‘evolving’ gel has been made that synergizes two strategies for forming interfaces with tissue.

We highlight some of the Nature Briefing’s stories from the end of 2023, including a polar bear fur-inspired sweater, efforts to open OSIRIS-REx’s sample canister, and a dinosaur’s last dinner.

We describe an imidodiphosphorimidate-catalysed asymmetric Wagner–Meerwein shift of aliphatic alkenyl cycloalkanes to cycloalkenes with excellent regio- and enantioselectivity.

Evidence for a quantum magnetic analogue of a supersolid appears in a recently synthesized antiferromagnet showing a strong magnetocaloric effect of the spin supersolid phase with potential for applications in sub-kelvin refrigeration.

tRNA display enables the direct selection of orthogonal aminoacyl-tRNA synthetases that acylate orthogonal tRNAs with non-canonical monomers, enabling in vivo synthesis of proteins that include these monomers and expanding the repertoire of the genetic code.

The use of mega-electronvolt ultrafast electron diffraction combined with resonance-enhanced multiphoton ionization yields data that can reveal the formation and subsequent structural relaxation of a molecular ion on an ultrafast timescale.

Integrated data, including 100 human genomes from the Mesolithic, Neolithic and Early Bronze Age periods show that two major population turnovers occurred over just 1,000 years in Neolithic Denmark, resulting in dramatic changes in the genes, diet and physical appearance of the local people, as well as the landscape in which they lived.

Analysis of naturally hybridizing swordtail fish species reveals a mitonuclear genetic incompatibility among three genes that encode components of mitochondrial respiratory complex I, providing insights into the emergence of hybrid incompatibilities and reproductive barriers.

The prokaryotic non-enzymatic effector protein Cam1 mediates CRISPR immunity by binding tetra-adenylate second messengers and forming a pore in the membrane that induces membrane depolarization and growth arrest.

A stripped-envelope supernova, SN 2022jli, shows 12.4-day periodic undulations during the declining light curve, and narrow Hα emission is detected in late-time spectra with concordant periodic velocity shifts.