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We highlight some Nature Briefing stories from the end of 2024, including the retraction saga of a controversial COVID study, the skin’s surprise immune-system and the running ability of our ancient relatives.
Diverse methyl β-C−H functionalizations of ketones and esters are enabled by cationic Pd(II) complexes with MPANA ligands, offering access to spirocyclic and fused ring systems through enhanced catalyst–substrate affinity.
We discuss the potential consequences and ethical concerns of polygenic genome editing of human embryos to alter specific variants associated with polygenic diseases, highlighting the possibility of reducing disease susceptibility while exacerbating health inequalities.
Using high-density electrophysiological recordings, how internally generated cell assemblies are updated by action plans to meet external goals is explored.
Janus graphene nanoribbons with localized states on a single zigzag edge are fabricated by introducing a topological defect array of benzene motifs on the opposite zigzag edge, to break the structural symmetry.
A small ferredoxin (Shethna protein II) of Azotobacter vinelandii can provide protection from O2 stress that may be crucial for the maintenance of recombinant nitrogenase in food crops.
The development of a molecularly defined spatiotemporal atlas of pathogen-infected Arabidopsis thaliana leaves reveals specific cell states that have distinct roles in plant immunity.
Divergent satellite DNA shapes influence architectural protein binding and chromatin organization in two mouse species so that the satellites can be packaged and centromere function maintained, mitigating the evolutionary cost of satellite DNA expansion.
Results from a comprehensive evaluation of the function of BRCA2 variants, particularly variants of uncertain significance, provide a useful resource to improve the clinical management of individuals who carry such genetic variants.
Experimental and theoretical evidence shows that incorporating finite interface widths extends fracture mechanics to include crack (and earthquake) nucleation; slow steady creep occurring at a well-defined stress threshold.
A meta-analysis of biodiversity effects on plant productivity found that complementarity effects increased over time whereas selection effects decreased, and both remained consistent across global variations in climate.
