Prostaglandin transporter OATP2A1/SLCO2A1is essential for body temperature regulation during fever
- Journal:
- Journal of Neuroscience
- Published:
- DOI:
- 10.1523/jneurosci.3276-17.2018
- Affiliations:
- 4
- Authors:
- 10
Research Highlight
Transport protein helps the brain run a fever
© Hiroshi Watanabe/Getty
A protein involved in ferrying fever-inducing substances to and within the brain offers a promising therapeutic target for treating
Scientists from Kanazawa University and elsewhere in Japan studied mice with and without a working version of the Slco2a1 gene, which encodes the transport protein involved in the cellular uptake of prostaglandin E2 (PGE2), an important mediator of the body’s heat-generating response to fever-stimulating signals from pathogens.
By comparing febrile responses in these mouse models, they showed this protein mediates transport of PGE2 across the blood–brain barrier. It also helps secrete the hormone-like substance from the inside
The findings help explain a certain
References
- Journal of Neuroscience 38, 5584–5595 (2018). doi: 10.1523/JNEUROSCI.3276-17.2018
Institutions | Authors | Share |
---|---|---|
Kanazawa University (KU), Japan | 0.67 | |
Teikyo University, Japan | 0.30 | |
Kindai University, Japan | 0.03 |