Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair

Journal:
Proceedings of the National Academy of Sciences of the United States of America
Published:
DOI:
10.1073/pnas.2207408119
Affiliations:
7
Authors:
14
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Research Highlight

How proteins help remove damaged DNA

© KTSDESIGN/SCIENCE PHOTO LIBRARY/Getty Images

The roles of two key proteins in excising damaged DNA have been elucidated for the first time.

The cellular machinery for repairing damaged DNA is a two-edged sword when it comes to cancer—it removes DNA damage that can lead to skin cancer, but it can also blunt the effectiveness of anti-cancer drugs by cutting out damage they inflict on tumour cells.

Researchers want to discover how nucleotide excision repair (NER) works so that they can find ways to make anti-cancer treatments more effective.

Now, a team led by researchers from the Institute for Basic Science in South Korea has shown that two of the more than 30 of the proteins that make up NER play critical but distinct roles. In particular, they position NER to make a cut once damaged DNA has been detected.

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References

  1. PNAS 119, e2207408119 (2022). doi: 10.1073/pnas.2207408119
Institutions Authors Share
Vanderbilt University (VU), United States of America (USA)
5.333333
 0.38
Division of Life Sciences, IBS, South Korea
4.833333
 0.35
The University of Texas MD Anderson Cancer Center, United States of America (USA)
2.000000
 0.14
Lawrence Berkeley National Laboratory (LBNL), United States of America (USA)
1.000000
 0.07
Ulsan National Institute of Science and Technology (UNIST), South Korea
0.833333
 0.06