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  • Aldehyde-bearing proteins are shown to be suitable substrates for Horner–Wadsworth–Emmons reactions. Applying this process to proteins and glycoproteins enables site-specific bioconjugation with tunable reaction kinetics.

    • Antonio Angelastro
    • Alexey Barkhanskiy
    • Sabine L. Flitsch
    ArticleOpen Access
  • Rational design of the morphology of inorganic microstructures is challenging. Now an electrochemical method is reported for designing the morphology of inorganic microarchitectures via programming of the potential waveforms applied during microstructure growth. These microstructures have potential application as SERS sensors.

    • Liyan Zhao
    • Yanling Wang
    • Shikuan Yang
  • A van der Waals epitaxial strategy is reported for growing intrinsic quantum dots (QDs) by modulating interfacial couplings on van der Waals surfaces. This method overcomes lattice mismatch constraints and produces versatile III–V and IV–VI QDs with controllable morphologies, broadening near-infrared photoresponse in InSb QDs/MoS2 by efficient interlayer charge transfer.

    • Kaiyao Xin
    • Lian Li
    • Shenqiang Zhai
  • The fragmentation of crystallization-driven self-assembly nanomaterials is only achievable with external stimuli. Now we report that two-dimensional platelets containing less stable domains can spontaneously fragment upon ageing, providing a simple one-step method for creating hollow platelet polymer particles.

    • Liping Liu
    • Calum T. J. Ferguson
    • Zaizai Tong
  • High-index facet nanostructures are deliberately targeted and synthesized by using a data-driven approach that integrates high-throughput density functional theory calculations, machine learning and experimental validation. The effectiveness of this approach is shown by the discovery and subsequent synthesis of seven monometallic and four multimetallic tetrahexahedron-shaped high-index facet nanoparticles.

    • Zihao Ye
    • Bo Shen
    • Chad A. Mirkin
  • The rational design and synthesis of dual-atom catalysts with structurally uniform and flexible active sites remains challenging. Now the tailored synthesis of a Janus Fe–Co dual-metal catalyst is reported in which the Fe and Co atoms are coordinated to N and O, respectively, and linked through bridging N and O atoms.

    • Bing Tang
    • Yanan Zhou
    • Wensheng Yan
  • An unstrained allylic C(sp3)–C(sp3) bond is transformed into a new C(sp3)–C(sp3) bond enantioselectively with palladium catalysts via kinetic resolution or dynamic kinetic asymmetric transformation (DYKAT). Mechanistic experiments and density functional theory calculations reveal that the deracemization needed for DYKAT occurs via the formation of diene intermediates.

    • Ye-Wei Chen
    • Yehao Qiu
    • Zhi-Tao He
  • Automated iterative small-molecule synthesis has generally been limited to around one carbon–carbon bond-forming step per day. Now, a next-generation automated synthesizer enables rapid, automated, iterative synthesis of a variety of small molecules. Improvements to chemistry and automation leads to a tenfold decrease in reaction time over previous automated platforms.

    • Wesley Wang
    • Nicholas H. Angello
    • Martin D. Burke
  • Electrochemical methods have great potential to help achieve net-zero emissions. Here, a method to synthesize ethylene carbonate is reported, which is electrochemically initiated and enables the concurrent production of hydrogen, capture of CO2 and subsequent conversion of the captured CO2 during ethylene carbonate synthesis.

    • Jun Ho Jang
    • Changsoo Kim
    • Ki Tae Nam
  • The synthesis, isolation and characterization of palladium complexes featuring one, two and three anionic aluminium ligands are reported, in which the aluminium ligands effectively stabilize the palladium in the zero-oxidation state. The aluminium–palladium bonds are highly polarized and the negatively charged palladium centre readily undergoes activation of B–B and C–N bonds.

    • Chenting Yan
    • Kota Koshino
    • Rei Kinjo
  • The isolation of secondary and primary carbon radical species is challenging, owing to their instability. Now the reduction of an acyclic bis(imino)carbene conjugate acid enables the isolation of a stable pentadienyl-type radical. In silico and in vitro probing of its properties reveal a propensity to act as a secondary carbon radical.

    • Ying Kai Loh
    • Levan Gojiashvili
    • Guy Bertrand
  • Biocatalytic methods for the synthesis of isoindolones, via C–H activation, have remained elusive. Now, an enantiodivergent artificial-metalloenzyme-catalysed method for the synthesis of chiral isoindolones is reported, using a streptavidin–biotin–Rh(III) catalyst system. Crystallographic analysis reveals the key residues that control stereoselectivity in streptavidin.

    • Prasun Mukherjee
    • Anjali Sairaman
    • Debabrata Maiti
  • The in situ generation of reactive (di)gallenes from a gallium–fluorobenzene complex and commercial chiral and achiral bisphosphine ligands is presented. The Ga(I) complex cations can undergo reversible cycloadditions to 1-alkenes and bond insertions into H–Si and H–B bonds.

    • Philipp Dabringhaus
    • Harald Scherer
    • Ingo Krossing
  • Renewable electricity-driven nitrogen oxidation is a green alternative to Haber–Bosch and Ostwald processes, but it is challenging to effectively steer oxygen intermediates towards the nitrogen oxidation reaction pathway. Now, to mitigate competing oxygen evolution and improve nitrogen oxidation efficiency, the use of hydroxyl radicals as the nitrogen oxidant is proposed.

    • Kai Dong
    • Yongchao Yao
    • Bo Tang