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  • By combining the link of a catenane with the interweaving of a trefoil knot, a molecular structure with a double knot-link containing 14 crossings is prepared. The knot-link contains two homochiral trefoil knots that are quadruply linked with each other.

    • Edward E. Fenlon
    News & Views
  • Crystal engineering of nanosized and hierarchical zeolites may improve the mass transport properties of materials at the nanoscale in various applications. In this Review, synthetic methods used to prepare different classes of zeolitic materials are summarized, with a focus on nucleation and growth mechanisms. Experimental and computational advances, as well as future challenges in the field, are discussed.

    • Adam J. Mallette
    • Seungwan Seo
    • Jeffrey D. Rimer
    Review Article
  • Scalable and efficient chemical recycling of commodity polymeric materials remains a challenge as the materials continually accumulate in the environment. Now, upcycling of polystyrene into benzoic acid and other value-added chemicals is realized under mild photooxidation conditions, with hydrogen atom transfer as the key step.

    • Mizhi Xu
    • Will R. Gutekunst
    News & Views
  • Nickel-catalysed cross-electrophile coupling (XEC) is a useful reaction in synthetic organic chemistry. Now, a nickel-catalysed electrochemical XEC reaction mediated by dynamic ligand exchange enables the formation of a C(sp2)–C(sp3) bond between tertiary alkyl bromides and aryl (pseudo)halides.

    • Huan-Ming Huang
    News & Views
  • Nature evolves diverse pathways for production of acetyl-CoA, a principal biosynthetic building block. Now, through in silico thermodynamic and kinetic analyses, this study proposes an acetyl-CoA biosynthetic route from C1 compounds and implements it in gas-fermenting bacteria for effective production of C2 metabolites.

    • Chao Wu
    • Jonathan Lo
    • Wei Xiong
  • Reversible alkyne metathesis proves its worth in the bulk synthesis of γ-graphyne, an spsp2-hybridized carbon allotrope. The ability to synthesize graphynes in bulk is an important step towards harnessing the properties of these graphene-like allotropes.

  • Accessing reactive ketyl-type radicals in mild and controllable ways represents an ambitious target. A study now reports a multicomponent palladium-photocatalysed reaction between aldehydes, 1,3-butadiene and various nucleophiles that affords complex homoallylic alcohols through ketyl-type radicals.

    Research Briefing
  • Interlocking between non-trivial molecular knots provides a route to topologically complex mechanically interlocked molecules. Now, a topologically chiral prime link with 14 crossings is synthesized in a stereoselective manner through the quadruple interlocking of two homochiral trefoil knots.

    • Zheng Cui
    • Guo-Xin Jin
  • Ketyl radicals can be used in a range of reactions, but their generation often requires harsh conditions and a large excess of reductants. Now, a multicomponent, palladium-photocatalysed reaction between aldehydes, 1,3-butadiene and N, S, O and C nucleophiles to build architecturally complex homoallylic alcohols is reported wherein ketyl-type radicals are generated under mild conditions.

    • Huan-Ming Huang
    • Peter Bellotti
    • Frank Glorius