• Reaction over cubic catalyst

    Ammonia is an essential global chemical but its synthesis is energy intensive and pollutes the environment. This Focus issue highlights recent developments in green ammonia synthesis, as well as discussing the challenges which need to be overcome for the commercial production of green ammonia.

  • Robot arms working in chemistry laboratory.

    The combination of techniques such as machine learning, artificial intelligence, robotics and automation can be used to accelerate chemical and materials synthesis. This Focus issue showcases developments in the automation and digitalization of synthesis, as well as highlights the challenges to be overcome in this area.

  • Pipes in chemical factory

    Flow chemistry is an enabling technology which is used to tackle synthetic problems in both industrial and academic settings. This Focus issue showcases how flow technologies can provide reaction outcomes which are distinct from the corresponding batch processes and how they can be applied in synthesis.

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Nature Synthesis is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

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  • Aldehyde-bearing proteins are shown to be suitable substrates for Horner–Wadsworth–Emmons reactions. Applying this process to proteins and glycoproteins enables site-specific bioconjugation with tunable reaction kinetics.

    • Antonio Angelastro
    • Alexey Barkhanskiy
    • Sabine L. Flitsch
    ArticleOpen Access
  • Rational design of the morphology of inorganic microstructures is challenging. Now an electrochemical method is reported for designing the morphology of inorganic microarchitectures via programming of the potential waveforms applied during microstructure growth. These microstructures have potential application as SERS sensors.

    • Liyan Zhao
    • Yanling Wang
    • Shikuan Yang
  • A van der Waals epitaxial strategy is reported for growing intrinsic quantum dots (QDs) by modulating interfacial couplings on van der Waals surfaces. This method overcomes lattice mismatch constraints and produces versatile III–V and IV–VI QDs with controllable morphologies, broadening near-infrared photoresponse in InSb QDs/MoS2 by efficient interlayer charge transfer.

    • Kaiyao Xin
    • Lian Li
    • Shenqiang Zhai
  • The fragmentation of crystallization-driven self-assembly nanomaterials is only achievable with external stimuli. Now we report that two-dimensional platelets containing less stable domains can spontaneously fragment upon ageing, providing a simple one-step method for creating hollow platelet polymer particles.

    • Liping Liu
    • Calum T. J. Ferguson
    • Zaizai Tong
  • Implementing a chemical C–N coupling step to intercept reactive intermediates in electrocatalytic CO2 or NOxy– reduction reactions is an emerging approach to sustainable electrosynthesis of organonitrogen compounds from cheap and abundant feedstocks.

    • Conor L. Rooney
    • Hailiang Wang
  • The electrochemical construction of C–N bonds from abundant CO2 and nitrogenous sources is of interest for the sustainable synthesis of value-added organonitrogen compounds, which requires comprehensive considerations of electrocatalysts, the interface microenvironment, mechanisms, reactors and paired reactions to push this area towards competition with traditional thermochemical methods.

    • Cuibo Liu
    • Ying Gao
    • Bin Zhang
  • Irreproducible synthetic methods consume time, money, and resources. Here, we highlight the steps Nature Synthesis takes to help authors make their synthetic procedures as reproducible as possible.