Volume 1 Issue 5 May 2016

Volume 1 Issue 5

This Perspective explores and explains the fundamental dogma of nanoparticle delivery to tumours and answers two central questions: ‘how many nanoparticles accumulate in a tumour?’ and ‘how does this number affect the clinical translation of nanomedicines?’

See Stefan Wilhelm et al. 1, 16014 (2016).

Image credit: Stefan Wilhelm. Cover design: Lauren V. Robinson

Research Highlights

Perspectives and Reviews

  • Perspective |

    This Perspective explores and explains the fundamental dogma of nanoparticle delivery to tumours and answers two central questions: ‘how many nanoparticles accumulate in a tumour?’ and ‘how does this number affect the clinical translation of nanomedicines?’

    • Stefan Wilhelm
    • , Anthony J. Tavares
    • , Qin Dai
    • , Seiichi Ohta
    • , Julie Audet
    • , Harold F. Dvorak
    •  & Warren C. W. Chan
  • Review Article |

    The incorporation of structural defects, in particular of interfaces, into crystalline lattices results in enhanced material properties. In this Review, different types of boundaries and interfaces are discussed, including high- and low-angle grain boundaries, twin boundaries, nanotwinned and nanolaminated structures, and gradient nanostructures.

    • K. Lu
  • Review Article |

    Membranes have an increasingly important role in alleviating water scarcity and the pollution of aquatic environments. Promising molecular-level design approaches are reviewed for membrane materials, focusing on how these materials address the urgent requirements of water treatment applications.

    • Jay R. Werber
    • , Chinedum O. Osuji
    •  & Menachem Elimelech
  • Review Article |

    The polymer materials of the twenty-first century will be complex chemical systems that can respond and adapt to their environment. Such materials can be attained by synthesizing precision macromolecules with controlled architectures, and by mastering polymer interactions and self-organization.

    • Jean-François Lutz
    • , Jean-Marie Lehn
    • , E. W. Meijer
    •  & Krzysztof Matyjaszewski