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New materials, beyond those that have already obtained regulatory approval, are needed to improve the bioavailability of orally administered proteins. In this Review, barriers to the oral delivery of protein-based therapies are discussed, along with the current translational landscape and state of the art of materials for oral protein delivery.
The reliable operation of solid-state batteries requires stable or passivating interfaces between solid components. In this Review, we discuss models for interfacial reactions and relate the predictions to experimental findings, aiming to provide a deeper understanding of interface stability.
Clinical outcomes with implantable and degradable devices largely depend on host response. This Review surveys material options and degradation mechanisms relevant to host responses to biodegradable devices, examines clinical translation of leading biodegradable materials and proposes updated material-design strategies to improve device performance.
Recently, scaling relationships have been established between certain physical or chemical properties of heterogeneous catalytic reactions. These properties, or reactivity descriptors, can describe and predict catalytic performance, and thus enable the rational design of new catalysts.
Non-radiative recombination losses hinder the performance of perovskite solar cells, preventing them from reaching the Shockley–Queisser limit. This Review systematically analyses the origin and impact of non-radiative recombination losses and highlights notable advances in their characterization and mitigation.
Hydrogel microparticles are used for numerous biomedical applications, owing to their unique multiscale properties and design versatility. This Review discusses various hydrogel microparticle fabrication techniques and their diverse applications, ranging from cell and drug delivery to 3D printing.
This Review discusses the expansion of the field of molecular magnetism from the chemical design and physical study of single-molecule magnets and multifunctional magnetic materials towards physics- and nanotechnology-driven areas, in particular molecular spintronics, quantum technologies, metal–organic frameworks and 2D materials.
Functional mesoporous materials with architectures ranging from 0D to 3D are typically prepared using surfactant-templating methods. This Review outlines the single-micelle-directed synthesis of mesoporous materials, including low-dimensional and 3D mesoporous structures, as well as hierarchical and asymmetric mesoporous structures.
In vivo genome editing requires delivery systems that are efficient, safe and tissue specific. This Review outlines the materials and delivery strategies currently used, and the challenges and potential solutions in in vivo genome editing, aiming to stimulate further development of engineered materials for in vivo delivery of genome-editing machinery.
